KEGG   DRUG: Epinephrine bitartrateHelp
Entry
D02149                      Drug                                   

Name
Epinephrine bitartrate (JAN/USP);
Asmatane mist (TN);
Medihaler-epi (TN)
Formula
C9H13NO3. C4H6O6
Exact mass
333.106
Mol weight
333.2913
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
 DG01592  COMT substrate
Remark
Activity
Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Indication: Bronchial asthma
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137];
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140];
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Salivary secretion
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC09 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA24 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA14 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AA Alpha- and beta-adrenoreceptor agonists
     R03AA01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA01 Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Epinephrine
    D02149  Epinephrine bitartrate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
    alpha2-adrenergic receptor
     Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
    beta1-adrenergic receptor
     Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
    beta2-adrenergic receptor
     Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
    beta3-adrenergic receptor
     Epinephrine
      D02149  Epinephrine bitartrate (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
51-42-3
PubChem: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    16.7785  -17.0333
            2   C8x C    16.7785  -18.4291
            3   C8x C    15.5689  -16.3355
            4   C1c C    17.9882  -16.3355
            5   C8x C    15.5689  -19.1735
            6   C8y C    14.3592  -17.0333
            7   C1b C    19.1978  -17.0333
            8   O1a O    17.9882  -14.9397
            9   C8y C    14.3592  -18.4291
            10  N1b N    20.4074  -16.3355
            11  O1a O    13.1496  -19.1269
            12  O1a O    13.1496  -16.3355
            13  C1a C    21.6171  -17.0333
            14  O6a O    25.0833  -17.0100
            15  C6a C    26.2958  -16.3100
            16  C1c C    27.5082  -17.0100
            17  C1c C    28.7207  -16.3100
            18  C6a C    29.9332  -17.0100
            19  O6a O    31.1456  -16.3100
            20  O6a O    29.9332  -18.4100
            21  O6a O    26.2958  -14.9100
            22  O1a O    28.7207  -14.9100
            23  O1a O    27.5082  -18.4100
BOND        22
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     3   6 2
            5     4   7 1
            6     4   8 1 #Up
            7     5   9 2
            8     7  10 1
            9     9  11 1
            10    6   9 1
            11    6  12 1
            12    1   2 2
            13   10  13 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   18  20 2
            20   15  21 2
            21   17  22 1 #Up
            22   16  23 1 #Up

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