KEGG   DRUG: D02157Help
Entry
D02157                      Drug                                   

Name
Benzylpenicillin benzathine hydrate (JP16);
Penicillin G benzathine (USP);
Bicillin L-A (TN);
Permapen (TN);
Wycillin (TN)
Product
Formula
(C16H18N2O4S)2. C16H20N2. 4H2O
Exact mass
980.4024
Mol weight
981.1848
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
penicillin binding proteins inhibitor
  Pathway
ko00550  Peptidoglycan biosynthesis  
 
Metabolism
Transporter: SLC22A8 [HSA:9376]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS
    J01CE Beta-lactamase sensitive penicillins
     J01CE08 Benzathine benzylpenicillin
      D02157  Benzylpenicillin benzathine hydrate (JP16); Penicillin G benzathine (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA14 Benzylpenicillin
      D02157  Benzylpenicillin benzathine hydrate (JP16); Penicillin G benzathine (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Penicillins
   Penicillin G
    D02157  Benzylpenicillin benzathine hydrate (JP16); Penicillin G benzathine (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   611  Acting mainly on gram-positive bacteria
    6111  Penicillins
     D02157  Benzylpenicillin benzathine hydrate (JP16); Penicillin G benzathine (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Penicillins
     Benzylpenicillin
      D02157  Benzylpenicillin benzathine hydrate (JP16); Penicillin G benzathine (USP)
     Benzathine benzylpenicillin
      D02157  Benzylpenicillin benzathine hydrate (JP16); Penicillin G benzathine (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02157  Benzylpenicillin benzathine hydrate
BRITE hierarchy
Other DBs
CAS: 
41372-02-5
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        68
            1   C8x C    27.8968  -12.4782
            2   C8x C    27.8968  -13.8826
            3   C8x C    29.1193  -14.5817
            4   C8y C    30.3282  -13.8826
            5   C8x C    30.3282  -12.4782
            6   C8x C    29.1193  -11.7729
            7   C1b C    31.5400  -14.5749
            8   N1b N    32.7570  -13.8762
            9   C1b C    33.9666  -14.5685
            10  C1b C    35.1771  -13.8697
            11  N1b N    36.3867  -14.5622
            12  C1b C    37.6035  -13.8635
            13  C8y C    38.8202  -14.5488
            14  C8x C    38.8243  -15.9472
            15  C8x C    40.0340  -16.6459
            16  C8x C    41.2469  -15.9400
            17  C8x C    41.2428  -14.5418
            18  C8x C    40.0260  -13.8492
            19  O0  O    34.6571  -17.4004
            20  C1y C    21.1200  -13.4726
            21  C5x C    21.1200  -14.8774
            22  N1y N    22.5249  -14.8774
            23  C1y C    22.5249  -13.4726
            24  C1y C    23.8594  -15.2988
            25  C1z C    24.7022  -14.1749
            26  S2x S    23.8594  -13.0510
            27  C1a C    25.6857  -15.1583
            28  C1a C    25.6857  -13.1915
            29  C6a C    24.3511  -16.6333
            30  O6a O    25.7558  -16.6333
            31  O6a O    23.5081  -17.7571
            32  N1b N    19.9259  -12.7701
            33  C5a C    18.7318  -13.4726
            34  O5x O    19.9259  -15.5797
            35  O5a O    18.7318  -14.8774
            36  C1b C    17.5123  -12.7750
            37  C8y C    16.3199  -13.4703
            38  C8x C    15.1063  -12.7696
            39  C8x C    13.8928  -13.4703
            40  C8x C    13.8928  -14.8715
            41  C8x C    15.1063  -15.5721
            42  C8x C    16.3199  -14.8715
            43  O0  O    34.6571  -17.4004
            44  O0  O    34.6571  -17.4004
            45  O0  O    34.6571  -17.4004
            46  C1y C    21.1200  -13.4726
            47  C5x C    21.1200  -14.8774
            48  N1y N    22.5249  -14.8774
            49  C1y C    22.5249  -13.4726
            50  S2x S    23.8594  -13.0510
            51  C1z C    24.7022  -14.1749
            52  C1y C    23.8594  -15.2988
            53  C6a C    24.3511  -16.6333
            54  O6a O    25.7558  -16.6333
            55  O6a O    23.5081  -17.7571
            56  C1a C    25.6857  -15.1583
            57  C1a C    25.6857  -13.1915
            58  O5x O    19.9259  -15.5797
            59  N1b N    19.9259  -12.7701
            60  C5a C    18.7318  -13.4726
            61  O5a O    18.7318  -14.8774
            62  C1b C    17.5123  -12.7750
            63  C8y C    16.3199  -13.4703
            64  C8x C    15.1063  -12.7696
            65  C8x C    13.8928  -13.4703
            66  C8x C    13.8928  -14.8715
            67  C8x C    15.1063  -15.5721
            68  C8x C    16.3199  -14.8715
BOND        69
            1     9  10 1
            2    10  11 1
            3    11  12 1
            4    12  13 1
            5    13  14 2
            6    14  15 1
            7    15  16 2
            8    16  17 1
            9    17  18 2
            10   18  13 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16    6   1 1
            17    4   7 1
            18    7   8 1
            19    8   9 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   20  23 1
            24   22  24 1
            25   24  25 1
            26   25  26 1
            27   23  26 1
            28   25  27 1
            29   25  28 1
            30   24  29 1 #Down
            31   29  30 1
            32   29  31 2
            33   20  32 1 #Up
            34   32  33 1
            35   21  34 2
            36   33  35 2
            37   33  36 1
            38   36  37 1
            39   37  38 2
            40   38  39 1
            41   39  40 2
            42   40  41 1
            43   41  42 2
            44   37  42 1
            45   46  47 1
            46   47  48 1
            47   48  49 1
            48   46  49 1
            49   48  52 1
            50   52  51 1
            51   51  50 1
            52   49  50 1
            53   51  56 1
            54   51  57 1
            55   52  53 1 #Down
            56   53  54 1
            57   53  55 2
            58   46  59 1 #Up
            59   59  60 1
            60   47  58 2
            61   60  61 2
            62   60  62 1
            63   62  63 1
            64   63  64 2
            65   64  65 1
            66   65  66 2
            67   66  67 1
            68   67  68 2
            69   63  68 1
BRACKET     1    32.6900  -18.2700   32.6900  -16.4500
            1    35.0700  -16.4500   35.0700  -18.2700
            1  4
 ORIGINAL  1   19
 REPEAT    1   44  45  46
            2    13.7200  -18.4100   13.7200  -11.3400
            2    27.0900  -11.3400   27.0900  -18.4100
            2  2
 ORIGINAL  2   20  21  22  23  26  25  24  29  30  31  27  28  32  35  33  34
            2   36  37  38  39  40  41  42  43
 REPEAT    2   47  48  49  50  51  52  53  54  55  56  57  58  59  60  61  62
            2   63  64  65  66  67  68  69  70

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