KEGG   DRUG: Croconazole hydrochlorideHelp
Entry
D02169                      Drug                                   

Name
Croconazole hydrochloride (JP17);
Pilzcin (TN)
Formula
C18H15ClN2O. HCl
Exact mass
346.064
Mol weight
347.2384
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antifungal
 DG01883  Imidazole antifungal
Cyp inhibitor
 DG01643  CYP2C9 inhibitor
Remark
Chemical group: 
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Imidazole derivative
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
Steroid biosynthesis
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Drug interaction
Structure map
Antifungal agents
Brite
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   sterol 14alpha-demethylase inhibitor
    Imidazoles
     Croconazole
      D02169  Croconazole hydrochloride (JP17)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C9
   Croconazole
    D02169  Croconazole hydrochloride (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02169  Croconazole hydrochloride
BRITE hierarchy
Other DBs
CAS: 
77174-66-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8x C    24.0097  -19.9517
            2   C8x C    24.4299  -18.6445
            3   N4y N    23.3095  -17.8043
            4   C8x C    22.1890  -18.6445
            5   N5x N    22.6092  -19.9517
            6   C8y C    24.5232  -14.3497
            7   C8y C    24.5232  -15.7036
            8   C8x C    25.7370  -16.4505
            9   C8x C    26.9508  -15.7503
            10  C8x C    26.9508  -14.3497
            11  C8x C    25.7370  -13.6028
            12  C8x C    18.5010  -12.2490
            13  C8x C    18.5010  -13.6495
            14  C8x C    19.7148  -14.3497
            15  C8y C    20.9286  -13.6495
            16  C8x C    20.9286  -12.2490
            17  C8y C    19.7148  -11.5487
            18  C1b C    22.0957  -14.3497
            19  O2a O    23.3095  -13.6028
            20  C2c C    23.3095  -16.4038
            21  C2a C    22.0957  -15.7036
            22  X   Cl   19.7148  -10.1482
            23  X   Cl   30.5899  -15.0033
BOND        24
            1    11   6 1
            2     1   2 2
            3     2   3 1
            4     3   4 1
            5     4   5 2
            6     5   1 1
            7    12  13 2
            8    13  14 1
            9    14  15 2
            10   15  16 1
            11   16  17 2
            12   17  12 1
            13    6   7 2
            14   15  18 1
            15    7   8 1
            16   18  19 1
            17   19   6 1
            18    8   9 2
            19    7  20 1
            20   20   3 1
            21    9  10 1
            22   20  21 2
            23   10  11 2
            24   17  22 1

» Japanese version   » Back

DBGET integrated database retrieval system