KEGG   DRUG: D02169Help
Entry
D02169                      Drug                                   

Name
Croconazole hydrochloride (JP16);
Pilzcin (TN)
Formula
C18H15ClN2O. HCl
Exact mass
346.064
Mol weight
347.2384
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antifungal
Target
sterol 14alpha-demethylase ihibitor [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis  
 
Interaction
CYP inhibition: CYP2C9 [HSA:1559]
Drug interaction
Structure map
Antifungal agents
Brite
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   sterol 14alpha-demethylase inhibitor
    Imidazoles
     Croconazole
      D02169  Croconazole hydrochloride (JP16)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2C9
   Croconazole
    D02169  Croconazole hydrochloride (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02169  Croconazole hydrochloride
BRITE hierarchy
Other DBs
CAS: 
77174-66-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8x C    24.0097  -19.9517
            2   C8x C    24.4299  -18.6445
            3   N4y N    23.3095  -17.8043
            4   C8x C    22.1890  -18.6445
            5   N5x N    22.6092  -19.9517
            6   C8y C    24.5232  -14.3497
            7   C8y C    24.5232  -15.7036
            8   C8x C    25.7370  -16.4505
            9   C8x C    26.9508  -15.7503
            10  C8x C    26.9508  -14.3497
            11  C8x C    25.7370  -13.6028
            12  C8x C    18.5010  -12.2490
            13  C8x C    18.5010  -13.6495
            14  C8x C    19.7148  -14.3497
            15  C8y C    20.9286  -13.6495
            16  C8x C    20.9286  -12.2490
            17  C8y C    19.7148  -11.5487
            18  C1b C    22.0957  -14.3497
            19  O2a O    23.3095  -13.6028
            20  C2c C    23.3095  -16.4038
            21  C2a C    22.0957  -15.7036
            22  X   Cl   19.7148  -10.1482
            23  X   Cl   30.5899  -15.0033
BOND        24
            1    11   6 1
            2     1   2 2
            3     2   3 1
            4     3   4 1
            5     4   5 2
            6     5   1 1
            7    12  13 2
            8    13  14 1
            9    14  15 2
            10   15  16 1
            11   16  17 2
            12   17  12 1
            13    6   7 2
            14   15  18 1
            15    7   8 1
            16   18  19 1
            17   19   6 1
            18    8   9 2
            19    7  20 1
            20   20   3 1
            21    9  10 1
            22   20  21 2
            23   10  11 2
            24   17  22 1

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