KEGG   DRUG: Grepafloxacin hydrochlorideHelp
Entry
D02178                      Drug                                   

Name
Grepafloxacin hydrochloride (JAN/USAN);
GPFX;
Raxar (TN)
Formula
C19H22FN3O3. HCl
Exact mass
395.1412
Mol weight
395.8556
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
ATC code: 
Chemical group: 
Activity
Antibaterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621] [KO:K02622]
Interaction
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA11 Grepafloxacin
      D02178  Grepafloxacin hydrochloride (JAN/USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Grepafloxacin
      D02178  Grepafloxacin hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Grepafloxacin
    D02178  Grepafloxacin hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
161967-81-3
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8y C    18.7662  -14.4318
            2   C8y C    18.7662  -15.8327
            3   C8x C    19.9832  -16.5296
            4   C8y C    19.9832  -13.7278
            5   C8y C    21.1862  -14.4318
            6   C8y C    21.1800  -15.8327
            7   N4y N    22.3913  -16.5347
            8   C8x C    23.6086  -15.8430
            9   C8y C    23.6145  -14.4420
            10  C8y C    22.4033  -13.7331
            11  C1y C    22.3774  -17.9306
            12  C6a C    24.8203  -13.7278
            13  O6a O    24.8833  -12.3269
            14  O6a O    26.0311  -14.4318
            15  C1a C    19.9698  -12.3269
            16  X   F    17.5481  -13.7278
            17  N1y N    17.5481  -16.5225
            18  C1x C    16.3381  -15.8189
            19  C1x C    15.1205  -16.5089
            20  N1x N    15.1124  -17.9095
            21  C1y C    16.3222  -18.6201
            22  C1x C    17.5401  -17.9233
            23  C1a C    16.3091  -20.0144
            24  C1x C    21.6683  -19.1310
            25  C1x C    23.0683  -19.1424
            26  O5x O    22.3916  -12.3269
            27  X   Cl   29.1020  -15.4718
BOND        29
            1     2   3 2
            2    12  13 2
            3     3   6 1
            4    12  14 1
            5     5   4 1
            6     4  15 1
            7     4   1 2
            8     1  16 1
            9     5   6 2
            10    2  17 1
            11    6   7 1
            12    7   8 1
            13    8   9 2
            14    9  10 1
            15   10   5 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22   21  23 1
            23    7  11 1
            24    1   2 1
            25   11  24 1
            26   11  25 1
            27   25  24 1
            28    9  12 1
            29   10  26 2

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