KEGG   DRUG: D02178Help
Entry
D02178                      Drug                                   

Name
Grepafloxacin hydrochloride (JAN/USAN);
GPFX;
Raxar (TN)
Formula
C19H22FN3O3. HCl
Exact mass
395.1412
Mol weight
395.8556
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibaterial
Remark
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621] [KO:K02622]
Interaction
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA11 Grepafloxacin
      D02178  Grepafloxacin hydrochloride (JAN/USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Grepafloxacin
      D02178  Grepafloxacin hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
161967-81-3
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8y C    18.7662  -14.4318
            2   C8y C    18.7662  -15.8327
            3   C8x C    19.9832  -16.5296
            4   C8y C    19.9832  -13.7278
            5   C8y C    21.1862  -14.4318
            6   C8y C    21.1800  -15.8327
            7   N4y N    22.3913  -16.5347
            8   C8x C    23.6086  -15.8430
            9   C8y C    23.6145  -14.4420
            10  C8y C    22.4033  -13.7331
            11  C1y C    22.3774  -17.9306
            12  C6a C    24.8203  -13.7278
            13  O6a O    24.8833  -12.3269
            14  O6a O    26.0311  -14.4318
            15  C1a C    19.9698  -12.3269
            16  X   F    17.5481  -13.7278
            17  N1y N    17.5481  -16.5225
            18  C1x C    16.3381  -15.8189
            19  C1x C    15.1205  -16.5089
            20  N1x N    15.1124  -17.9095
            21  C1y C    16.3222  -18.6201
            22  C1x C    17.5401  -17.9233
            23  C1a C    16.3091  -20.0144
            24  C1x C    21.6683  -19.1310
            25  C1x C    23.0683  -19.1424
            26  O5x O    22.3916  -12.3269
            27  X   Cl   29.1020  -15.4718
BOND        29
            1     2   3 2
            2    12  13 2
            3     3   6 1
            4    12  14 1
            5     5   4 1
            6     4  15 1
            7     4   1 2
            8     1  16 1
            9     5   6 2
            10    2  17 1
            11    6   7 1
            12    7   8 1
            13    8   9 2
            14    9  10 1
            15   10   5 1
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22   21  23 1
            23    7  11 1
            24    1   2 1
            25   11  24 1
            26   11  25 1
            27   25  24 1
            28    9  12 1
            29   10  26 2

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