KEGG   DRUG: D02181Help
Entry
D02181                      Drug                                   

Name
Sisomicin sulfate (JAN/USP);
Siseptin (TN)
Formula
(C19H37N5O7)2. 5H2SO4
Exact mass
1384.3755
Mol weight
1385.4452
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
ATC code: 
Drug group: 
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB08 Sisomicin
      D02181  Sisomicin sulfate (JAN/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Sisomicin
      D02181  Sisomicin sulfate (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
53179-09-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        87
            1   C1y C    28.1673  -17.0155
            2   C1y C    29.3663  -17.7176
            3   C1y C    28.1673  -15.6094
            4   O2a O    26.9496  -17.6942
            5   C1x C    30.5770  -17.0272
            6   N1a N    29.3604  -19.1295
            7   C1y C    29.3780  -14.9193
            8   O1a O    26.9613  -14.9076
            9   C1y C    25.7318  -18.3959
            10  C1y C    30.5711  -15.6341
            11  O2a O    29.4085  -13.5203
            12  C1y C    25.7445  -19.7950
            13  O2x O    24.5210  -17.7000
            14  N1a N    31.9281  -15.2645
            15  C1y C    30.6320  -12.8358
            16  C1y C    24.5326  -20.4980
            17  O1a O    26.9554  -20.4794
            18  C1x C    23.3033  -18.4147
            19  O2x O    31.8439  -13.5203
            20  C1y C    30.6320  -11.4310
            21  C1z C    23.3091  -19.8007
            22  N1b N    24.5515  -21.8971
            23  C2y C    33.0487  -12.8358
            24  C1x C    31.8439  -10.7279
            25  N1a N    29.4202  -10.7279
            26  O1a O    21.8795  -20.0255
            27  C1a C    23.5513  -22.8844
            28  C2x C    33.0487  -11.4310
            29  C1b C    34.2723  -13.5203
            30  N1a N    34.2782  -14.9193
            31  C1a C    23.0554  -21.1867
            32  S4a S    40.7256  -16.5812
            33  O1d O    39.3266  -16.5753
            34  O1d O    42.1247  -16.5812
            35  O1d O    40.7197  -15.1879
            36  O1d O    40.7197  -17.9803
            37  C1y C    28.1673  -17.0155
            38  C1y C    29.3663  -17.7176
            39  C1x C    30.5770  -17.0272
            40  C1y C    30.5711  -15.6341
            41  N1a N    31.9281  -15.2645
            42  C1y C    29.3780  -14.9193
            43  C1y C    28.1673  -15.6094
            44  O1a O    26.9613  -14.9076
            45  O2a O    29.4085  -13.5203
            46  C1y C    30.6320  -12.8358
            47  O2x O    31.8439  -13.5203
            48  C2y C    33.0487  -12.8358
            49  C2x C    33.0487  -11.4310
            50  C1x C    31.8439  -10.7279
            51  C1y C    30.6320  -11.4310
            52  N1a N    29.4202  -10.7279
            53  C1b C    34.2723  -13.5203
            54  N1a N    34.2782  -14.9193
            55  N1a N    29.3604  -19.1295
            56  O2a O    26.9496  -17.6942
            57  C1y C    25.7318  -18.3959
            58  C1y C    25.7445  -19.7950
            59  C1y C    24.5326  -20.4980
            60  C1z C    23.3091  -19.8007
            61  C1x C    23.3033  -18.4147
            62  O2x O    24.5210  -17.7000
            63  O1a O    21.8795  -20.0255
            64  C1a C    23.0554  -21.1867
            65  N1b N    24.5515  -21.8971
            66  C1a C    23.5513  -22.8844
            67  O1a O    26.9554  -20.4794
            68  S4a S    40.7256  -16.5812
            69  O1d O    39.3266  -16.5753
            70  O1d O    42.1247  -16.5812
            71  O1d O    40.7197  -15.1879
            72  O1d O    40.7197  -17.9803
            73  S4a S    40.7256  -16.5812
            74  O1d O    39.3266  -16.5753
            75  O1d O    42.1247  -16.5812
            76  O1d O    40.7197  -15.1879
            77  O1d O    40.7197  -17.9803
            78  S4a S    40.7256  -16.5812
            79  O1d O    39.3266  -16.5753
            80  O1d O    42.1247  -16.5812
            81  O1d O    40.7197  -15.1879
            82  O1d O    40.7197  -17.9803
            83  S4a S    40.7256  -16.5812
            84  O1d O    39.3266  -16.5753
            85  O1d O    42.1247  -16.5812
            86  O1d O    40.7197  -15.1879
            87  O1d O    40.7197  -17.9803
BOND        86
            1    18  21 1
            2    24  28 1
            3     1   2 1
            4     1   3 1
            5     1   4 1 #Down
            6     2   5 1
            7     2   6 1 #Up
            8     3   7 1
            9     3   8 1 #Up
            10    9   4 1 #Down
            11    5  10 1
            12    7  11 1 #Down
            13    9  12 1
            14    9  13 1
            15   10  14 1 #Up
            16   15  11 1 #Down
            17   12  16 1
            18   12  17 1 #Down
            19   13  18 1
            20   15  19 1
            21   15  20 1
            22   16  21 1
            23   16  22 1 #Up
            24   19  23 1
            25   20  24 1
            26   20  25 1 #Down
            27   21  26 1 #Up
            28   22  27 1
            29   23  28 2
            30   23  29 1
            31   29  30 1
            32    7  10 1
            33   21  31 1 #Down
            34   61  60 1
            35   50  49 1
            36   37  38 1
            37   37  43 1
            38   37  56 1 #Down
            39   38  39 1
            40   38  55 1 #Up
            41   43  42 1
            42   43  44 1 #Up
            43   57  56 1 #Down
            44   39  40 1
            45   42  45 1 #Down
            46   57  58 1
            47   57  62 1
            48   40  41 1 #Up
            49   46  45 1 #Down
            50   58  59 1
            51   58  67 1 #Down
            52   62  61 1
            53   46  47 1
            54   46  51 1
            55   59  60 1
            56   59  65 1 #Up
            57   47  48 1
            58   51  50 1
            59   51  52 1 #Down
            60   60  63 1 #Up
            61   65  66 1
            62   48  49 2
            63   48  53 1
            64   53  54 1
            65   42  40 1
            66   60  64 1 #Down
            67   32  33 1
            68   32  34 1
            69   32  35 2
            70   32  36 2
            71   68  69 1
            72   68  70 1
            73   68  71 2
            74   68  72 2
            75   73  74 1
            76   73  75 1
            77   73  76 2
            78   73  77 2
            79   78  79 1
            80   78  80 1
            81   78  81 2
            82   78  82 2
            83   83  84 1
            84   83  85 1
            85   83  86 2
            86   83  87 2
BRACKET     1    20.4400  -24.2900   20.4400  -10.0800
            1    35.7700  -10.0800   35.7700  -24.2900
            1  2
 ORIGINAL  1    1   2   5  10  14   7   3   8  11  15  19  23  28  24  20  25
            1   29  30   6   4   9  12  16  21  18  13  26  31  22  27  17
 REPEAT    1   37  38  39  40  41  42  43  44  45  46  47  48  49  50  51  52
            1   53  54  55  56  57  58  59  60  61  62  63  64  65  66  67
            2    37.8700  -18.9000   37.8700  -14.2800
            2    43.4000  -14.2800   43.4000  -18.9000
            2  5
 ORIGINAL  2   32  33  34  35  36
 REPEAT    2   68  69  70  71  72  73  74  75  76  77  78  79  80  81  82  83
            2   84  85  86  87

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