KEGG   DRUG: D02185Help
Entry
D02185                      Drug                                   

Name
Chloramphenicol sodium succinate (JP16/USP);
CP;
Chloromycetin succinate (TN)
Product
  Generic
Formula
C15H15Cl2N2O8. Na
Exact mass
444.0103
Mol weight
445.184
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial;
Antirickettsial [DS:H00111 H00112 H00312 H00319 H00322 H00324 H00336]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
prodrug, active substance: Chloramphenicol [DR:D00104]
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP16/USP)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP16/USP)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP16/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP16/USP)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP16/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6151  Chloramphenicols
     D02185  Chloramphenicol sodium succinate (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Amphenicols
     Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP16/USP)
 Inhbitors
  CYP2C19
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP16/USP)
  CYP3A4
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP16/USP)
  CYP3A5
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP16/USP)
  CYP3A7
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02185  Chloramphenicol sodium succinate
BRITE hierarchy
Other DBs
CAS: 
982-57-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    21.3161  -15.5137
            2   C1c C    21.3153  -16.9056
            3   C8x C    20.1197  -14.7987
            4   C8x C    22.5374  -14.8000
            5   C1c C    22.5186  -17.6023
            6   O1a O    20.1125  -17.5884
            7   C8x C    20.1205  -13.3951
            8   C8x C    22.5380  -13.3964
            9   N1b N    23.7158  -16.9128
            10  C8y C    21.3175  -12.7058
            11  C5a C    24.9188  -17.6095
            12  N2b N    21.3185  -11.3139 #+
            13  C1c C    26.1289  -16.9199
            14  O5a O    24.9182  -19.0013
            15  O3a O    20.1220  -10.6173
            16  O3a O    22.5166  -10.6070 #-
            17  X   Cl   27.3249  -17.6166
            18  X   Cl   26.0890  -15.5280
            19  C1b C    22.5172  -19.0063
            20  O7a O    21.3020  -19.7065
            21  C7a C    21.3006  -21.1401
            22  O6a O    20.0910  -21.8371
            23  C1b C    22.5548  -21.8661
            24  C1b C    23.7829  -21.1588
            25  C6a C    24.9813  -21.8524
            26  O6a O    26.1975  -21.1519 #-
            27  O6a O    24.9798  -23.2741
            28  Z   Na   27.7330  -21.4961 #+
BOND        27
            1     5   9 1
            2     7  10 2
            3     9  11 1
            4    10  12 1
            5    11  13 1
            6    11  14 2
            7    12  15 2
            8    12  16 1
            9    13  17 1
            10   13  18 1
            11    8  10 1
            12    1   2 1
            13    1   3 2
            14    1   4 1
            15    2   5 1
            16    2   6 1 #Down
            17    3   7 1
            18    4   8 2
            19    5  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 2
            23   21  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   25  27 2

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