KEGG   DRUG: Chloramphenicol sodium succinateHelp
Entry
D02185                      Drug                                   

Name
Chloramphenicol sodium succinate (JP17/USP);
CP;
Chloromycetin succinate (TN)
Product
  Generic
Formula
C15H15Cl2N2O8. Na
Exact mass
444.0103
Mol weight
445.184
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01576  Amphenicol type antibacterial
Cyp substrate
 DG01639  CYP2C19 substrate
Cyp inhibitor
 DG01522  CYP3A4 inhibitor
 DG01915  CYP3A5 ihibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antibacterial, Antirickettsial, Protein biosynthesis inhibitor
Comment
Amphenicol derivative
Active form of prodrug: Chloramphenicol [DR:D00104]
Target
50S ribosomal subunit
  Pathway
Ribosome
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP17/USP)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP17/USP)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP17/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP17/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP17/USP)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP17/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP17/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6151  Chloramphenicols
     D02185  Chloramphenicol sodium succinate (JP17/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   50S subunit inhibitor
    Amphenicols
     Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP17/USP)
  CYP3A4
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP17/USP)
  CYP3A5
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP17/USP)
  CYP3A7
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP17/USP)
 CYP substrates
  CYP2C19
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02185  Chloramphenicol sodium succinate
Antibacterials [br08350.html]
 D02185
BRITE hierarchy
Other DBs
CAS: 
982-57-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    21.3161  -15.5137
            2   C1c C    21.3153  -16.9056
            3   C8x C    20.1197  -14.7987
            4   C8x C    22.5374  -14.8000
            5   C1c C    22.5186  -17.6023
            6   O1a O    20.1125  -17.5884
            7   C8x C    20.1205  -13.3951
            8   C8x C    22.5380  -13.3964
            9   N1b N    23.7158  -16.9128
            10  C8y C    21.3175  -12.7058
            11  C5a C    24.9188  -17.6095
            12  N2b N    21.3185  -11.3139 #+
            13  C1c C    26.1289  -16.9199
            14  O5a O    24.9182  -19.0013
            15  O3a O    20.1220  -10.6173
            16  O3a O    22.5166  -10.6070 #-
            17  X   Cl   27.3249  -17.6166
            18  X   Cl   26.0890  -15.5280
            19  C1b C    22.5172  -19.0063
            20  O7a O    21.3020  -19.7065
            21  C7a C    21.3006  -21.1401
            22  O6a O    20.0910  -21.8371
            23  C1b C    22.5548  -21.8661
            24  C1b C    23.7829  -21.1588
            25  C6a C    24.9813  -21.8524
            26  O6a O    26.1975  -21.1519 #-
            27  O6a O    24.9798  -23.2741
            28  Z   Na   27.7330  -21.4961 #+
BOND        27
            1     5   9 1
            2     7  10 2
            3     9  11 1
            4    10  12 1
            5    11  13 1
            6    11  14 2
            7    12  15 2
            8    12  16 1
            9    13  17 1
            10   13  18 1
            11    8  10 1
            12    1   2 1
            13    1   3 2
            14    1   4 1
            15    2   5 1
            16    2   6 1 #Down
            17    3   7 1
            18    4   8 2
            19    5  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 2
            23   21  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   25  27 2

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