KEGG   DRUG: D02197Help
Entry
D02197                      Drug                                   

Name
Vincristine sulfate (JP16/USP);
VCR;
Marqibo (TN);
Oncovin (TN);
Vincasar (TN);
Vincrex (TN)
Product
  Generic
Formula
C46H56N4O10. H2SO4
Exact mass
922.367
Mol weight
923.0361
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Catharanthus roseus [TAX:4058]
Activity
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
beta-tubulin, tubulin polymerization inhibitor [HSA:10381 10382 10383 203068 347688 347733 56604 7280 81027 84617] [KO:K07375]
  Pathway
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antineoplastics - agents from natural products
Immunosuppressive agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   424  Plant extract preparations
    4240  Plant extract preparations
     D02197  Vincristine sulfate (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
    L01CA Vinca alkaloids and analogues
     L01CA02 Vincristine
      D02197  Vincristine sulfate (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Others
  Cytoskeleton proteins
   beta-tubulin [HSA:10381 10382 10383 203068 347688 347733 56604 7280 81027 84617] [KO:K07375]
    Vincristine [ATC:L01CA02]
     D02197  Vincristine sulfate (JP16/USP)
Antineoplastics [BR:br08308]
 Natural products
  Mitotic inhibitor
   Vincristine [ATC:L01CA02]
    D02197  Vincristine sulfate (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
2068-78-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        65
            1   S4a S    29.0733  -14.7233
            2   O1d O    29.0733  -13.3233
            3   O1d O    29.0733  -16.1233
            4   O1d O    30.4733  -14.7233
            5   O1d O    27.6733  -14.7233
            6   C1z C    22.8169  -19.7891
            7   C1y C    23.9475  -19.1224
            8   C1y C    22.8227  -21.0939
            9   C8y C    20.5671  -19.7891
            10  C1x C    21.9820  -18.7107
            11  C1z C    25.0900  -19.7834
            12  N1y N    23.9359  -17.8003
            13  C1z C    23.9591  -21.7433
            14  N1y N    21.6862  -21.7433
            15  C8y C    20.5671  -21.0939
            16  C8x C    19.4305  -19.1397
            17  C1x C    22.6430  -17.7950
            18  C1y C    25.0316  -21.0997
            19  C2x C    26.2207  -19.1108
            20  C1b C    26.1859  -20.4155
            21  C1x C    25.0841  -17.1393
            22  C7a C    24.8522  -22.9221
            23  O1a O    23.4663  -23.6453
            24  C4a C    21.0426  -22.8391
            25  C8x C    19.4305  -21.7492
            26  C8y C    18.3230  -19.7834
            27  O7a O    27.5332  -21.9476
            28  C2x C    26.2264  -17.7887
            29  C1a C    27.2991  -19.7777
            30  O7a O    24.8414  -24.1920
            31  C8y C    18.3230  -21.0939
            32  C1z C    15.8281  -17.4039
            33  C7a C    28.8147  -22.0060
            34  C1a C    23.6751  -24.9167
            35  O2a O    17.2097  -21.7317
            36  C8y C    14.7033  -16.6443
            37  C1x C    17.0921  -16.6676
            38  C7a C    15.4686  -18.7029
            39  C1a C    29.4468  -20.8753
            40  O6a O    29.4700  -23.1018
            41  C1a C    16.0965  -21.0822
            42  C8y C    14.7033  -15.2991
            43  N4x N    13.5783  -17.3170
            44  C1y C    17.0921  -15.3803
            45  O7a O    14.0307  -19.1610
            46  O6a O    16.2977  -19.7351
            47  C8y C    12.3896  -15.2991
            48  C1x C    13.9784  -14.1973
            49  C8y C    12.3896  -16.6443
            50  C1x C    15.9557  -14.7657
            51  C1x C    18.1760  -14.5627
            52  C1a C    13.1608  -20.5816
            53  C8x C    11.2473  -14.6324
            54  C1x C    14.7495  -13.2116
            55  C8x C    11.2473  -17.3170
            56  N1y N    15.9557  -13.5247
            57  C1z C    18.2171  -13.4205
            58  C8x C    10.1688  -15.2991
            59  C8x C    10.1688  -16.6443
            60  C1x C    17.0864  -12.7710
            61  C1b C    19.7248  -13.9481
            62  O1a O    19.0579  -12.1273
            63  C1a C    20.7858  -13.3103
            64  O6a O    26.1576  -22.3898
            65  O4a O    19.6700  -22.8285
BOND        72
            1     1   2 2
            2     1   3 2
            3     1   4 1
            4     1   5 1
            5     6   7 1
            6     6   8 1
            7     6   9 1
            8     6  10 1 #Up
            9     7  11 1
            10    7  12 1
            11    8  13 1
            12    8  14 1
            13    9  15 2
            14    9  16 1
            15   10  17 1
            16   11  18 1
            17   11  19 1
            18   11  20 1 #Down
            19   12  21 1
            20   13  22 1 #Down
            21   13  23 1 #Up
            22   14  24 1
            23   15  25 1
            24   16  26 2
            25   18  27 1 #Up
            26   19  28 2
            27   20  29 1
            28   22  30 1
            29   25  31 2
            30   32  26 1 #Down
            31   27  33 1
            32   30  34 1
            33   31  35 1
            34   32  36 1
            35   32  37 1
            36   32  38 1 #Up
            37   33  39 1
            38   33  40 2
            39   35  41 1
            40   36  42 2
            41   36  43 1
            42   37  44 1
            43   38  45 1
            44   38  46 2
            45   42  47 1
            46   42  48 1
            47   43  49 1
            48   44  50 1 #Down
            49   44  51 1
            50   45  52 1
            51   47  53 1
            52   48  54 1
            53   49  55 1
            54   56  50 1 #Down
            55   51  57 1
            56   53  58 2
            57   55  59 2
            58   56  60 1
            59   57  61 1 #Down
            60   57  62 1 #Up
            61   61  63 1
            62   12  17 1
            63   13  18 1
            64   14  15 1
            65   21  28 1
            66   26  31 1
            67   47  49 2
            68   54  56 1
            69   57  60 1
            70   58  59 1
            71   22  64 2
            72   24  65 2

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