KEGG   DRUG: Pilocarpine hydrochlorideHelp
Entry
D02200                      Drug                                   

Name
Pilocarpine hydrochloride (JP17/USP);
Isopto carpine (TN);
Pilopine HS (TN);
Sanpilo (TN)
Product
  Generic
Formula
C11H16N2O2. HCl
Exact mass
244.0979
Mol weight
244.7179
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Other
 DG01719  Parasympathomimetic agent
Cyp substrate
 DG01638  CYP2A6 substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiglaucoma, Miotic, Salivation accelaletor, Muscarinic receptor agonist
Target
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D02200  Pilocarpine hydrochloride (JP17/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D02200  Pilocarpine hydrochloride (JP17/USP)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Pilocarpine
   D02200  Pilocarpine hydrochloride (JP17/USP)
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Pilocarpine
    D02200  Pilocarpine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1312  Miotic agents
     D02200  Pilocarpine hydrochloride (JP17/USP)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D02200  Pilocarpine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Pilocarpine
      D02200  Pilocarpine hydrochloride (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2A6
   Pilocarpine
    D02200  Pilocarpine hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02200  Pilocarpine hydrochloride
  D02200  Pilocarpine hydrochloride tablets
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from histidine
   Imidazole alkaloids
    D02200  Pilocarpine hydrochloride (JP15/USP)
Gastrointestinal agents [br08371.html]
 Agent for intraoral diseases
  D02200
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D02200
BRITE hierarchy
Other DBs
CAS: 
54-71-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C1y C    22.9454  -19.7221
            2   C1y C    21.4986  -19.7221
            3   C1b C    24.1589  -20.3289
            4   C1x C    23.3654  -18.3687
            5   C7x C    21.0786  -18.3687
            6   C1b C    20.7052  -20.8422
            7   C8y C    25.2323  -19.7221
            8   O7x O    22.2454  -17.5286
            9   O6a O    19.7251  -17.9019
            10  C1a C    19.3051  -20.8422
            11  N4y N    26.6324  -19.7221
            12  C8x C    24.7656  -18.3687
            13  C8x C    27.0525  -18.3687
            14  C1a C    27.4725  -20.8422
            15  N5x N    25.9323  -17.5286
            16  X   Cl   29.8072  -18.8353
BOND        16
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2

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