KEGG   DRUG: D02200Help
Entry
D02200                      Drug                                   

Name
Pilocarpine hydrochloride (JP16/USP);
Isopto carpine (TN);
Pilopine HS (TN);
Sanpilo (TN)
Product
  Generic
Formula
C11H16N2O2. HCl
Exact mass
244.0979
Mol weight
244.7179
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cholinergic [ophthalmic] [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor agonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04810  Regulation of actin cytoskeleton
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion  
 
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D02200  Pilocarpine hydrochloride (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D02200  Pilocarpine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Pilocarpine
   D02200  Pilocarpine hydrochloride (JP16/USP)
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Pilocarpine
    D02200  Pilocarpine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1312  Miotic agents
     D02200  Pilocarpine hydrochloride (JP16/USP)
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D02200  Pilocarpine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Pilocarpine
      D02200  Pilocarpine hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2A6
   Pilocarpine
    D02200  Pilocarpine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02200  Pilocarpine hydrochloride
  D02200  Pilocarpine hydrochloride tablets
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from histidine
   Imidazole alkaloids
    D02200  Pilocarpine hydrochloride (JP15/USP)
BRITE hierarchy
Other DBs
CAS: 
54-71-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C1y C    22.9454  -19.7221
            2   C1y C    21.4986  -19.7221
            3   C1b C    24.1589  -20.3289
            4   C1x C    23.3654  -18.3687
            5   C7x C    21.0786  -18.3687
            6   C1b C    20.7052  -20.8422
            7   C8y C    25.2323  -19.7221
            8   O7x O    22.2454  -17.5286
            9   O6a O    19.7251  -17.9019
            10  C1a C    19.3051  -20.8422
            11  N4y N    26.6324  -19.7221
            12  C8x C    24.7656  -18.3687
            13  C8x C    27.0525  -18.3687
            14  C1a C    27.4725  -20.8422
            15  N5x N    25.9323  -17.5286
            16  X   Cl   29.8072  -18.8353
BOND        16
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2

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