KEGG   DRUG: D02206Help
Entry
D02206                      Drug                                   

Name
Buformin hydrochloride (JP16);
Dibetos-B (TN)
Formula
C6H15N5. HCl
Exact mass
193.1094
Mol weight
193.6777
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
Therapeutic category: 
ATC code: 
Comment
biguanides
Target
AMPK activator [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04140  Regulation of autophagy
hsa04150  mTOR signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway  
 
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3962  Biguanides
     D02206  Buformin hydrochloride (JP16)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA03 Buformin
      D02206  Buformin hydrochloride (JP16)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK [HSA:5562 5563] [KO:K07198]
     Buformin [ATC:A10BA03]
      D02206  Buformin hydrochloride (JP16)
BRITE hierarchy
Other DBs
CAS: 
1190-53-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   N1b N    26.1791  -14.3037
            2   C2c C    24.9663  -15.0034
            3   C1b C    27.3919  -15.0034
            4   N1b N    23.7535  -14.3037
            5   N2a N    24.9663  -16.4028
            6   C1b C    28.6047  -14.3037
            7   C2c C    22.5407  -15.0034
            8   C1b C    29.8175  -15.0034
            9   N1a N    21.3280  -14.3037
            10  N2a N    22.5407  -16.4028
            11  C1a C    31.0303  -14.3037
            12  X   Cl   18.8300  -15.7500
BOND        10
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 1
            8     7   9 1
            9     7  10 2
            10    8  11 1

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