KEGG   DRUG: Buformin hydrochlorideHelp
Entry
D02206                      Drug                                   

Name
Buformin hydrochloride (JP17);
Dibetos-B (TN)
Formula
C6H15N5. HCl
Exact mass
193.1094
Mol weight
193.6777
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
Unclassified
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antidiabetic, Hypoglycemic
Comment
biguanides
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
Autophagy - animal
mTOR signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA03 Buformin
      D02206  Buformin hydrochloride (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3962  Biguanides
     D02206  Buformin hydrochloride (JP17)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK
     Buformin
      D02206  Buformin hydrochloride (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02206  Buformin hydrochloride
  D02206  Buformin hydrochloride tablets
  D02206  Buformin hydrochloride enteric-coated tablets
Antidiabetics [br08361.html]
 D02206
BRITE hierarchy
Other DBs
CAS: 
1190-53-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   N1b N    26.1791  -14.3037
            2   C2c C    24.9663  -15.0034
            3   C1b C    27.3919  -15.0034
            4   N1b N    23.7535  -14.3037
            5   N2a N    24.9663  -16.4028
            6   C1b C    28.6047  -14.3037
            7   C2c C    22.5407  -15.0034
            8   C1b C    29.8175  -15.0034
            9   N1a N    21.3280  -14.3037
            10  N2a N    22.5407  -16.4028
            11  C1a C    31.0303  -14.3037
            12  X   Cl   18.8300  -15.7500
BOND        10
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 1
            8     7   9 1
            9     7  10 2
            10    8  11 1

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