KEGG   DRUG: Buformin hydrochlorideHelp
Entry
D02206                      Drug                                   

Name
Buformin hydrochloride (JP17);
Dibetos-B (TN)
Formula
C6H15N5. HCl
Exact mass
193.1094
Mol weight
193.6777
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Remark
Therapeutic category: 3962
ATC code: A10BA03
Chemical structure group: DG00114
Product (DG00114): D02206<JP>
Efficacy
Antidiabetic, Hypoglycemic
Comment
Biguanide
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04152  AMPK signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
Interaction
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA03 Buformin
      D02206  Buformin hydrochloride (JP17) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3962  Biguanides
     D02206  Buformin hydrochloride (JP17)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CAMKL family
    AMPK (PRKAA)
     D02206  Buformin hydrochloride (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02206  Buformin hydrochloride
  D02206  Buformin hydrochloride tablets
  D02206  Buformin hydrochloride enteric-coated tablets
Drug classes of therapeutic agents [br08360.html]
 Antidiabetic agents
  D02206
BRITE hierarchy
Other DBs
CAS: 1190-53-0
PubChem: 7849266
LigandBox: D02206
NIKKAJI: J1.884.244K
KCF data Show

ATOM        12
            1   N1b N    26.1791  -14.3037
            2   C2c C    24.9663  -15.0034
            3   C1b C    27.3919  -15.0034
            4   N1b N    23.7535  -14.3037
            5   N2a N    24.9663  -16.4028
            6   C1b C    28.6047  -14.3037
            7   C2c C    22.5407  -15.0034
            8   C1b C    29.8175  -15.0034
            9   N1a N    21.3280  -14.3037
            10  N2a N    22.5407  -16.4028
            11  C1a C    31.0303  -14.3037
            12  X   Cl   18.8300  -15.7500
BOND        10
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     6   8 1
            8     7   9 1
            9     7  10 2
            10    8  11 1

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