KEGG   DRUG: D02212Help
Entry
D02212                      Drug                                   

Name
Ipratropium bromide hydrate (JP16);
Ipratropium bromide (USAN);
Atrovent (TN)
Product
  Generic
IPRATROPIUM BROMIDE (Aidarex Pharmaceuticals LLC), IPRATROPIUM BROMIDE (Bausch & Lomb Incorporated), IPRATROPIUM BROMIDE (Bausch & Lomb Incorporated), IPRATROPIUM BROMIDE (Cardinal Health), IPRATROPIUM BROMIDE (Cardinal Health), IPRATROPIUM BROMIDE (Mylan Pharmaceuticals), IPRATROPIUM BROMIDE (Nephron Pharmaceuticals Corporation), IPRATROPIUM BROMIDE (Physicians Total Care), IPRATROPIUM BROMIDE (Physicians Total Care), IPRATROPIUM BROMIDE (Physicians Total Care), IPRATROPIUM BROMIDE (Preferred Pharmaceuticals), IPRATROPIUM BROMIDE (Preferred Pharmaceuticals), IPRATROPIUM BROMIDE (REMEDYREPACK), IPRATROPIUM BROMIDE (REMEDYREPACK), IPRATROPIUM BROMIDE (REMEDYREPACK), IPRATROPIUM BROMIDE (REMEDYREPACK), IPRATROPIUM BROMIDE (Rebel Distributors Corp), IPRATROPIUM BROMIDE (Rebel Distributors Corp), IPRATROPIUM BROMIDE (Rebel Distributors Corp), IPRATROPIUM BROMIDE (Ritedose Pharmaceuticals), IPRATROPIUM BROMIDE (Roxane Laboratories), IPRATROPIUM BROMIDE (Roxane Laboratories), IPRATROPIUM BROMIDE (Sandoz), IPRATROPIUM BROMIDE (St Marys Medical Park Pharmacy), IPRATROPIUM BROMIDE (Watson Laboratories)
  Other
Formula
C20H30NO3. Br. H2O
Exact mass
429.1515
Mol weight
430.3764
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Bronchodilator [DS:H00079]
Remark
Therapeutic category: 
ATC code: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AX Other nasal preparations
     R01AX03 Ipratropium bromide
      D02212  Ipratropium bromide hydrate (JP16); Ipratropium bromide (USAN)
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BB Anticholinergics
     R03BB01 Ipratropium bromide
      D02212  Ipratropium bromide hydrate (JP16); Ipratropium bromide (USAN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Anticholinergic
   Ipratropium
    D02212  Ipratropium bromide hydrate (JP16); Ipratropium bromide (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D02212  Ipratropium bromide hydrate (JP16); Ipratropium bromide (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Ipratropium bromide
      D02212  Ipratropium bromide (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02212  Ipratropium bromide hydrate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D02212  Ipratropium bromide hydrate (JP15); Ipratropium bromide (USAN)
BRITE hierarchy
Other DBs
CAS: 
22254-24-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   O0  O    36.0414  -15.4183
            2   C1x C    21.9338  -15.2408
            3   C1x C    22.2619  -14.0691
            4   C1y C    23.1055  -14.9596
            5   C1y C    23.4336  -13.7879
            6   N2y N    22.1682  -12.4756 #+
            7   C1x C    24.9802  -14.9596
            8   C1x C    24.6990  -13.7879
            9   C1y C    26.0113  -15.5220
            10  O7a O    27.0893  -16.4125
            11  C7a C    28.3079  -16.4125
            12  C1c C    28.9172  -15.3345
            13  O6a O    28.9172  -17.5373
            14  C8y C    30.1358  -15.3345
            15  C1b C    28.3079  -14.3034
            16  O1a O    28.9172  -13.2255
            17  C8x C    30.8420  -16.5582
            18  C8x C    32.2420  -16.5585
            19  C8x C    32.9422  -15.3462
            20  C8x C    32.2361  -14.1225
            21  C8x C    30.8361  -14.1222
            22  C1a C    21.4191  -11.2914
            23  C1c C    20.9389  -13.0883
            24  C1a C    19.7662  -12.3118
            25  C1a C    20.9231  -14.4879
            26  X   Br   25.9700  -11.4800 #-
BOND        26
            1     2   3 1
            2     2   4 1
            3     3   5 1
            4     4   6 1
            5     4   7 1
            6     5   8 1
            7     7   9 1
            8     9  10 1 #Down
            9    10  11 1
            10   11  12 1
            11   11  13 2
            12   12  14 1
            13   12  15 1
            14   15  16 1
            15    5   6 1
            16    8   9 1
            17   14  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   14  21 1
            23    6  22 1
            24    6  23 1
            25   23  24 1
            26   23  25 1

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