KEGG   DRUG: D02217Help
Entry
D02217                      Drug                                   

Name
Raloxifene hydrochloride (JAN/USP);
LY 156758;
Evista (TN)
Product
  Generic
Formula
C28H27NO4S. HCl
Exact mass
509.1428
Mol weight
510.0442
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-estrogen
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Selective estrogen receptor modulators (SERM)
Target
estrogen receptor 1 agonist/antagonist [HSA:2099] [KO:K08550];
estrogen receptor 2 agonist/antagonist [HSA:2100] [KO:K08551]
  Pathway
hsa04961  Endocrine and other factor-regulated calcium reabsorption  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03X OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
    G03XC Selective estrogen receptor modulators
     G03XC01 Raloxifene
      D02217  Raloxifene hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Selective Estrogen Receptor Modifying Agents
   Raloxifene
    D02217  Raloxifene hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D02217  Raloxifene hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   Estrogen receptor
    estrogen receptor 1
     Raloxifene
      D02217  Raloxifene hydrochloride (JAN/USP)
    estrogen receptor 2
     Raloxifene
      D02217  Raloxifene hydrochloride (JAN/USP)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonists
  Estrogen antagonist
   Raloxifene
    D02217  Raloxifene hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
82640-04-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   X   Cl   28.3116  -20.4635
            2   C8y C    19.6000  -24.7100
            3   C8x C    19.6000  -26.1100
            4   C8x C    20.7900  -26.8100
            5   C8y C    22.0500  -26.1100
            6   C8x C    22.0500  -24.7100
            7   C8x C    20.7900  -24.0100
            8   C5a C    18.4100  -24.0100
            9   C8y C    17.2200  -24.7100
            10  O5a O    18.4100  -22.6100
            11  O2a O    23.2400  -26.8100
            12  C1b C    24.4300  -26.1100
            13  C1b C    25.6200  -26.8100
            14  N1y N    26.8100  -26.1100
            15  C1x C    28.0000  -26.8100
            16  C1x C    29.2600  -26.1100
            17  C1x C    29.2600  -24.7100
            18  C1x C    28.0700  -24.0100
            19  C1x C    26.8100  -24.7100
            20  C8y C    16.1000  -23.8700
            21  S2x S    14.9800  -24.6400
            22  C8y C    15.4000  -25.9700
            23  C8y C    16.7300  -25.9700
            24  C8x C    14.6300  -27.1600
            25  C8y C    15.3300  -28.4200
            26  C8x C    16.7300  -28.4200
            27  C8x C    17.4300  -27.2300
            28  C8y C    16.1000  -22.4700
            29  C8x C    14.9100  -20.3700
            30  C8x C    14.9100  -21.7700
            31  C8x C    17.3600  -21.7700
            32  C8x C    17.3600  -20.3700
            33  C8y C    16.1000  -19.6700
            34  O1a O    16.1000  -18.2700
            35  O1a O    14.6200  -29.6266
BOND        38
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     8   9 1
            9     8  10 2
            10    5  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   14  19 1
            20    9  20 2
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24    9  23 1
            25   22  24 2
            26   24  25 1
            27   25  26 2
            28   26  27 1
            29   23  27 2
            30   20  28 1
            31   29  30 2
            32   30  28 1
            33   31  32 1
            34   32  33 2
            35   29  33 1
            36   33  34 1
            37   28  31 2
            38   25  35 1

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