KEGG   DRUG: D02217Help
Entry
D02217                      Drug                                   

Name
Raloxifene hydrochloride (JAN/USP);
LY 156758;
Evista (TN)
Product
  Generic
Formula
C28H27NO4S. HCl
Exact mass
509.1428
Mol weight
510.0442
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-estrogen
Remark
Therapeutic category: 
ATC code: 
Comment
Selective estrogen receptor modulators (SERM)
Target
estrogen receptor 1 agonist/antagonist [HSA:2099] [KO:K08550];
estrogen receptor 2 agonist/antagonist [HSA:2100] [KO:K08551]
  Pathway
hsa04961  Endocrine and other factor-regulated calcium reabsorption  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Osteoporosis drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D02217  Raloxifene hydrochloride (JAN/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03X OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
    G03XC Selective estrogen receptor modulators
     G03XC01 Raloxifene
      D02217  Raloxifene hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Selective Estrogen Receptor Modifying Agents
   Raloxifene
    D02217  Raloxifene hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   Estrogen receptor
    estrogen receptor 1 [HSA:2099] [KO:K08550]
     Raloxifene [ATC:G03XC01]
      D02217  Raloxifene hydrochloride (JAN/USP)
    estrogen receptor 2 [HSA:2100] [KO:K08551]
     Raloxifene [ATC:G03XC01]
      D02217  Raloxifene hydrochloride (JAN/USP)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonist
  Estrogen antagonist
   Raloxifene [ATC:G03XC01]
    D02217  Raloxifene hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
82640-04-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   X   Cl   31.2900  -11.8300
            2   C8y C    26.2932  -11.9505
            3   C5a C    26.2932  -10.5462
            4   C8y C    25.0995   -9.8441
            5   C8x C    27.5569  -12.6526
            6   O5a O    27.5569   -9.8441
            7   C8y C    25.0995   -8.4399
            8   C8y C    26.3111   -7.7403
            9   C8x C    27.4950   -8.4239
            10  C8x C    28.7093   -7.7230
            11  C8y C    28.7093   -6.3210
            12  C8x C    27.5252   -5.6374
            13  C8x C    26.3111   -6.3383
            14  C8x C    25.1624  -12.6704
            15  C8x C    25.1155  -14.0702
            16  C8y C    26.3792  -14.7723
            17  C8x C    27.5800  -14.0524
            18  O1a O    29.9237   -5.6199
            19  O2a O    26.4023  -16.1699
            20  C1b C    27.6024  -16.8700
            21  C1b C    28.8149  -16.1700
            22  N1y N    30.0273  -16.8700
            23  C1x C    30.0273  -18.2700
            24  C1x C    31.2397  -18.9700
            25  C1x C    32.4522  -18.2700
            26  C1x C    32.4522  -16.8700
            27  C1x C    31.2397  -16.1700
            28  S2x S    23.7640   -8.0059
            29  C8y C    22.9386   -9.1420
            30  C8y C    23.7640  -10.2781
            31  C8x C    21.5462   -9.2883
            32  C8y C    20.9768  -10.5673
            33  C8x C    21.8022  -11.7034
            34  C8x C    23.1946  -11.5570
            35  O1a O    19.6072  -10.7113
BOND        38
            1     2   3 1
            2     3   4 1
            3     2   5 2
            4     3   6 2
            5     4   7 2
            6     7   8 1
            7     8   9 2
            8     9  10 1
            9    10  11 2
            10   11  12 1
            11   12  13 2
            12    8  13 1
            13    2  14 1
            14   14  15 2
            15   15  16 1
            16   16  17 2
            17    5  17 1
            18   11  18 1
            19   16  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   22  27 1
            29    7  28 1
            30   28  29 1
            31   29  30 2
            32    4  30 1
            33   29  31 1
            34   31  32 2
            35   32  33 1
            36   33  34 2
            37   30  34 1
            38   32  35 1

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