KEGG   DRUG: D02234Help
Entry
D02234                      Drug                                   

Name
Cyproheptadine hydrochloride (JP16/USP);
Periactin (TN)
Product
  Generic
CYPROHEPTADINE (Pharmaceutical Associates), CYPROHEPTADINE HYDROCHLORIDE (Actavis Mid Atlantic LLC), CYPROHEPTADINE HYDROCHLORIDE (AvKARE), CYPROHEPTADINE HYDROCHLORIDE (Breckenridge Pharmaceutical), CYPROHEPTADINE HYDROCHLORIDE (Bryant Ranch Prepack), CYPROHEPTADINE HYDROCHLORIDE (C.O. Truxton), CYPROHEPTADINE HYDROCHLORIDE (Cardinal Health), CYPROHEPTADINE HYDROCHLORIDE (Carilion Materials Management), CYPROHEPTADINE HYDROCHLORIDE (CorePharma), CYPROHEPTADINE HYDROCHLORIDE (Cypress Pharmaceutical), CYPROHEPTADINE HYDROCHLORIDE (NCS HealthCare of KY), CYPROHEPTADINE HYDROCHLORIDE (Par Pharmaceutical), CYPROHEPTADINE HYDROCHLORIDE (Physicians Total Care), CYPROHEPTADINE HYDROCHLORIDE (Physicians Total Care), CYPROHEPTADINE HYDROCHLORIDE (REMEDYREPACK), CYPROHEPTADINE HYDROCHLORIDE (REMEDYREPACK), CYPROHEPTADINE HYDROCHLORIDE (REMEDYREPACK), CYPROHEPTADINE HYDROCHLORIDE (REMEDYREPACK), CYPROHEPTADINE HYDROCHLORIDE (Rising Pharmaceuticals), CYPROHEPTADINE HYDROCHLORIDE (Rising Pharmaceuticals), CYPROHEPTADINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), CYPROHEPTADINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), CYPROHEPTADINE HYDROCHLORIDE (Teva Pharmaceuticals USA)
Formula
(C21H21N)2. 2HCl. 3H2O
Exact mass
700.3198
Mol weight
701.764
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic;
Antipruritic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX02 Cyproheptadine
      D02234  Cyproheptadine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Cyproheptadine
    D02234  Cyproheptadine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D02234  Cyproheptadine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Cyproheptadine
      D02234  Cyproheptadine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02234  Cyproheptadine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
41354-29-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        49
            1   X   Cl   29.9601  -12.3900
            2   O0  O    30.5201  -15.4700
            3   C2x C    21.6757  -18.3177
            4   C8y C    20.8313  -17.2050
            5   C8y C    21.1674  -15.8445
            6   C2y C    22.4319  -15.2648
            7   C2x C    23.0854  -18.3430
            8   C8y C    23.6889  -15.8888
            9   C8y C    23.9762  -17.2613
            10  C8x C    20.1575  -14.8734
            11  C8x C    18.8118  -15.2626
            12  C8x C    18.4757  -16.6231
            13  C8x C    19.4856  -17.5939
            14  C8x C    25.3110  -17.6996
            15  C8x C    26.3581  -16.7626
            16  C8x C    26.0710  -15.3901
            17  C8x C    24.7359  -14.9518
            18  C2y C    22.4319  -13.8648
            19  C1x C    23.6222  -13.1772
            20  C1x C    23.6218  -11.7772
            21  N1y N    22.4092  -11.0775
            22  C1x C    21.2189  -11.7651
            23  C1x C    21.2193  -13.1651
            24  C1a C    22.4089   -9.6600
            25  X   Cl   29.9601  -12.3900
            26  O0  O    30.5201  -15.4700
            27  O0  O    30.5201  -15.4700
            28  C2x C    21.6757  -18.3177
            29  C2x C    23.0854  -18.3430
            30  C8y C    23.9762  -17.2613
            31  C8y C    23.6889  -15.8888
            32  C2y C    22.4319  -15.2648
            33  C8y C    21.1674  -15.8445
            34  C8y C    20.8313  -17.2050
            35  C8x C    19.4856  -17.5939
            36  C8x C    18.4757  -16.6231
            37  C8x C    18.8118  -15.2626
            38  C8x C    20.1575  -14.8734
            39  C2y C    22.4319  -13.8648
            40  C1x C    23.6222  -13.1772
            41  C1x C    23.6218  -11.7772
            42  N1y N    22.4092  -11.0775
            43  C1x C    21.2189  -11.7651
            44  C1x C    21.2193  -13.1651
            45  C1a C    22.4089   -9.6600
            46  C8x C    24.7359  -14.9518
            47  C8x C    26.0710  -15.3901
            48  C8x C    26.3581  -16.7626
            49  C8x C    25.3110  -17.6996
BOND        50
            1     5   6 1
            2     3   7 2
            3     6   8 1
            4     4   5 1
            5     7   9 1
            6     3   4 1
            7     8   9 1
            8     5  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12    4  13 2
            13    9  14 2
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17    8  17 2
            18    6  18 2
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   18  23 1
            25   21  24 1
            26   33  32 1
            27   28  29 2
            28   32  31 1
            29   34  33 1
            30   29  30 1
            31   28  34 1
            32   31  30 1
            33   33  38 2
            34   38  37 1
            35   37  36 2
            36   36  35 1
            37   34  35 2
            38   30  49 2
            39   49  48 1
            40   48  47 2
            41   47  46 1
            42   31  46 2
            43   32  39 2
            44   39  40 1
            45   40  41 1
            46   41  42 1
            47   42  43 1
            48   43  44 1
            49   39  44 1
            50   42  45 1
BRACKET     1    28.2800  -13.3000   28.2800  -11.4100
            1    30.9400  -11.4100   30.9400  -13.3000
            1  2
 ORIGINAL  1    1
 REPEAT    1   25
            2    28.3500  -16.3800   28.3500  -14.5600
            2    31.3600  -14.5600   31.3600  -16.3800
            2  3
 ORIGINAL  2    2
 REPEAT    2   26  27
            3    18.2700  -18.7600   18.2700   -9.1700
            3    26.9500   -9.1700   26.9500  -18.7600
            3  2
 ORIGINAL  3    3   7   9   8   6   5   4  13  12  11  10  18  19  20  21  22
            3   23  24  17  16  15  14
 REPEAT    3   28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43
            3   44  45  46  47  48  49

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