KEGG   DRUG: D02235Help
Entry
D02235                      Drug                                   

Name
Desmopressin acetate hydrate (JAN);
Desmopressin acetate (USAN);
Desmopressin acetate trihydrate;
DDAVP (TN);
Minirinmelt (TN);
Stimate (TN)
Product
  Generic
DESMOPRESSIN ACETATE (American Health Packaging), DESMOPRESSIN ACETATE (American Health Packaging), DESMOPRESSIN ACETATE (Apotex Corp.), DESMOPRESSIN ACETATE (Apotex Corp.), DESMOPRESSIN ACETATE (AvKARE), DESMOPRESSIN ACETATE (AvPAK), DESMOPRESSIN ACETATE (Bauch & Lomb Incorporated), DESMOPRESSIN ACETATE (BluePoint Laboratories), DESMOPRESSIN ACETATE (Bryant Ranch Prepack), DESMOPRESSIN ACETATE (Hospira), DESMOPRESSIN ACETATE (NCS HealthCare of KY), DESMOPRESSIN ACETATE (Physicians Total Care), DESMOPRESSIN ACETATE (Physicians Total Care), DESMOPRESSIN ACETATE (Prasco Laboratories), DESMOPRESSIN ACETATE (Sun Pharma Global FZE), DESMOPRESSIN ACETATE (Sun Pharmaceutical Industries Limited), DESMOPRESSIN ACETATE (Sun Pharmaceutical Industries Limited), DESMOPRESSIN ACETATE (Teva Parenteral Medicines), DESMOPRESSIN ACETATE (Teva Pharmaceuticals USA), DESMOPRESSIN ACETATE (UDL Laboratories), DESMOPRESSIN ACETATE (Watson Laboratories)
Formula
C46H64N14O12S2. C2H4O2. 3H2O
Exact mass
1182.4798
Mol weight
1183.3148
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiuretic
Remark
Therapeutic category: 
ATC code: 
Comment
Arg-vasopressin [DR:D02983] derivative
Target
arginine vasopressin receptor 1A (AVPR1A) agonist [HSA:552] [KO:K04226];
arginine vasopressin receptor 1B (AVPR1B) agonist [HSA:553] [KO:K04227];
arginine vasopressin receptor 2 (AVPR2) agonist [HSA:554] [KO:K04228];
factor VIII activator [HSA:2157] [KO:K03899]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04962  Vasopressin-regulated water reabsorption  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   241  Pituitary hormone preparations
    2419  Others
     D02235  Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01B POSTERIOR PITUITARY LOBE HORMONES
    H01BA Vasopressin and analogues
     H01BA02 Desmopressin
      D02235  Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Pituitary)
  Desmopressin
   D02235  Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Vasopressin
    arginine vasopressin receptor 1A (AVPR1A) [HSA:552] [KO:K04226]
     Desmopressin [ATC:H01BA02]
      D02235  Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN)
    arginine vasopressin receptor 1B (AVPR1B) [HSA:553] [KO:K04227]
     Desmopressin [ATC:H01BA02]
      D02235  Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN)
    arginine vasopressin receptor 2 (AVPR2) [HSA:554] [KO:K04228]
     Desmopressin [ATC:H01BA02]
      D02235  Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN)
 Enzymes
  Hydrolases
   coagulation factor VIII [HSA:2157] [KO:K03899]
    Desmopressin [ATC:H01BA02]
     D02235  Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN)
BRITE hierarchy
Other DBs
CAS: 
62357-86-2
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        81
            1   C1a C    32.3832  -21.0137
            2   C6a C    33.5970  -20.3133
            3   O6a O    34.8108  -21.0137
            4   O6a O    33.5970  -18.9128
            5   N1y N    18.8548  -17.5639
            6   C1y C    19.2754  -18.8259
            7   C5a C    18.8548  -16.2553
            8   C1x C    17.5461  -17.6107
            9   C5a C    20.4440  -19.4802
            10  C1x C    18.2472  -19.6205
            11  C1y C    20.0233  -15.6009
            12  O5a O    17.7331  -15.6009
            13  C1x C    17.1722  -18.8726
            14  N1b N    21.5657  -18.8259
            15  O5a O    20.4440  -20.7889
            16  N1x N    20.0233  -14.2923
            17  C1x C    21.1450  -16.2553
            18  C1c C    22.7342  -19.4802
            19  C5x C    21.1450  -13.5911
            20  S3x S    22.3135  -15.6009
            21  C5a C    22.7342  -20.7889
            22  C1b C    23.8559  -18.8259
            23  C1y C    21.1450  -12.2825
            24  O5x O    22.3135  -14.2923
            25  S3x S    23.4353  -16.2553
            26  N1b N    23.8559  -21.4434
            27  O5a O    21.5657  -21.4434
            28  C1b C    25.0244  -19.4802
            29  N1x N    20.0233  -11.6281
            30  C1b C    22.3135  -11.6281
            31  C1x C    24.5570  -15.6009
            32  C1b C    25.0244  -20.7889
            33  C1b C    26.1461  -18.8259
            34  C5x C    20.0233  -10.3194
            35  C5a C    23.4353  -12.2825
            36  C1x C    25.7255  -16.2553
            37  C1y C    22.0331   -9.5716
            38  O5x O    18.8548   -9.6650
            39  N1a N    24.5570  -11.6281
            40  O5a O    23.4353  -13.5911
            41  C5x C    26.8473  -15.6009
            42  N1x N    23.9027  -10.3194
            43  C1b C    22.0331   -7.8890
            44  N1x N    28.0157  -16.2553
            45  O5x O    26.8473  -14.2923
            46  C5x C    25.7722   -9.5716
            47  C1b C    20.9113   -7.1879
            48  C1y C    29.1375  -15.6009
            49  C1y C    28.0157  -10.3194
            50  O5x O    25.7722   -8.2628
            51  C5a C    19.7429   -7.8422
            52  C1b C    30.3059  -16.2553
            53  C5x C    29.1375  -14.2923
            54  C1b C    29.3244   -9.6650
            55  N1x N    28.0157  -13.3810
            56  N1a N    18.6211   -7.1412
            57  O5a O    19.7429   -9.1509
            58  C8y C    31.4276  -15.6009
            59  O5x O    30.3059  -13.5911
            60  C8y C    30.4929  -10.2726
            61  C8x C    32.5494  -16.2553
            62  C8x C    31.4276  -14.2455
            63  C8x C    30.4929  -11.5813
            64  C8x C    31.6613   -9.5716
            65  C8x C    33.7178  -15.6009
            66  C8x C    32.5494  -13.5911
            67  C8x C    31.6613  -12.2357
            68  C8x C    32.7831  -10.2726
            69  C8y C    33.7178  -14.2455
            70  C8x C    32.7831  -11.5813
            71  O1a O    34.8396  -13.5911
            72  C5a C    26.1929  -21.4901
            73  N1a N    27.4548  -20.7889
            74  O5a O    26.1929  -22.8922
            75  N1b N    27.3614  -19.5270
            76  C2c C    28.5765  -18.8259
            77  N1a N    29.7918  -19.5270
            78  N2a N    28.5765  -17.4237
            79  O0  O    34.2778  -22.8153
            80  O0  O    34.2778  -22.8153
            81  O0  O    34.2778  -22.8153
BOND        80
            1     1   2 1
            2     2   3 1
            3     2   4 2
            4     5   6 1
            5     5   7 1
            6     5   8 1
            7     6   9 1
            8     6  10 1
            9     7  11 1
            10    7  12 2
            11    8  13 1
            12    9  14 1
            13    9  15 2
            14   11  16 1
            15   11  17 1
            16   14  18 1
            17   16  19 1
            18   17  20 1
            19   18  21 1
            20   18  22 1
            21   19  23 1
            22   19  24 2
            23   20  25 1
            24   21  26 1
            25   21  27 2
            26   22  28 1
            27   23  29 1
            28   23  30 1
            29   25  31 1
            30   26  32 1
            31   28  33 1
            32   29  34 1
            33   30  35 1
            34   31  36 1
            35   34  37 1
            36   34  38 2
            37   35  39 1
            38   35  40 2
            39   36  41 1
            40   37  42 1
            41   37  43 1
            42   41  44 1
            43   41  45 2
            44   42  46 1
            45   43  47 1
            46   44  48 1
            47   46  49 1
            48   46  50 2
            49   47  51 1
            50   48  52 1
            51   48  53 1
            52   49  54 1
            53   49  55 1
            54   51  56 1
            55   51  57 2
            56   52  58 1
            57   53  59 2
            58   54  60 1
            59   58  61 2
            60   58  62 1
            61   60  63 2
            62   60  64 1
            63   61  65 1
            64   62  66 2
            65   63  67 1
            66   64  68 2
            67   65  69 2
            68   67  70 2
            69   69  71 1
            70   10  13 1
            71   53  55 1
            72   66  69 1
            73   68  70 1
            74   32  72 1
            75   72  73 1
            76   72  74 2
            77   33  75 1
            78   75  76 1
            79   76  77 1
            80   76  78 2
BRACKET     1    32.2000  -23.5200   32.2000  -22.0500
            1    34.7900  -22.0500   34.7900  -23.5200
            1  3
 ORIGINAL  1   79
 REPEAT    1   80  81

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