| Entry |
|
|---|
| Name |
Alimemazine tartrate (JP16);
Trimeprazine tartrate (USP);
Alimezine (TN)
|
|---|
| Formula |
(C18H22N2S)2. C4H6O6
|
|---|
| Exact mass |
746.3172
|
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| Mol weight |
746.9782
|
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| Structure |
     |
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| Activity |
Antipruritic
|
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| Remark |
Therapeutic category: ATC code: |
|---|
| Target |
|
|---|
| Pathway |
hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction | |
|
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| Interaction |
|
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| Structure map |
| Phenothiazines | | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
44 Allergic agents
441 Antihistamines
4413 Phenothiazines
D02245 Alimemazine tartrate (JP16); Trimeprazine tartrate (USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AD Phenothiazine derivatives
R06AD01 Alimemazine
D02245 Alimemazine tartrate (JP16); Trimeprazine tartrate (USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
H1-receptor [HSA:3269] [KO:K04149]
Alimemazine [ATC:R06AD01]
D02245 Trimeprazine tartrate (USP)
 |
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| Other DBs |
CAS: 4330-99-8 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 52
1 C1c C 31.5967 -17.3868
2 C1c C 30.3821 -18.0876
3 C6a C 32.8114 -18.0876
4 O1a O 31.5909 -15.9795
5 C6a C 29.1733 -17.3868
6 O1a O 30.3762 -19.4892
7 O6a O 34.0202 -17.3868
8 O6a O 32.7997 -19.4892
9 O6a O 27.9587 -18.0876
10 O6a O 29.1674 -15.9795
11 C8y C 19.4170 -19.9845
12 N1y N 20.6259 -19.2895
13 C8y C 19.4170 -21.3684
14 C8x C 18.2140 -19.2895
15 C8y C 21.8404 -19.9845
16 C1b C 20.6259 -17.8646
17 S2x S 20.6259 -22.0809
18 C8x C 18.2140 -22.0634
19 C8x C 17.0053 -20.0019
20 C8y C 21.8404 -21.3860
21 C8x C 23.0609 -19.2895
22 C1c C 21.8404 -17.1638
23 C8x C 17.0053 -21.3684
24 C8x C 23.0609 -22.0809
25 C8x C 24.2757 -19.9845
26 C1b C 21.8404 -15.7624
27 C1a C 23.0609 -17.8822
28 C8x C 24.2757 -21.3684
29 N1c N 23.0609 -15.0734
30 C1a C 24.2757 -15.7856
31 C1a C 23.0609 -13.6718
32 C8y C 19.4170 -19.9845
33 N1y N 20.6259 -19.2895
34 C8y C 21.8404 -19.9845
35 C8y C 21.8404 -21.3860
36 C8x C 23.0609 -22.0809
37 C8x C 24.2757 -21.3684
38 C8x C 24.2757 -19.9845
39 C8x C 23.0609 -19.2895
40 S2x S 20.6259 -22.0809
41 C8y C 19.4170 -21.3684
42 C8x C 18.2140 -22.0634
43 C8x C 17.0053 -21.3684
44 C8x C 17.0053 -20.0019
45 C8x C 18.2140 -19.2895
46 C1b C 20.6259 -17.8646
47 C1c C 21.8404 -17.1638
48 C1b C 21.8404 -15.7624
49 N1c N 23.0609 -15.0734
50 C1a C 24.2757 -15.7856
51 C1a C 23.0609 -13.6718
52 C1a C 23.0609 -17.8822
BOND 55
1 2 6 1 #Up
2 3 7 1
3 3 8 2
4 5 9 1
5 5 10 2
6 1 2 1
7 1 3 1
8 1 4 1 #Up
9 2 5 1
10 11 12 1
11 11 13 2
12 11 14 1
13 12 15 1
14 12 16 1
15 13 17 1
16 13 18 1
17 14 19 2
18 15 20 2
19 15 21 1
20 16 22 1
21 18 23 2
22 20 24 1
23 21 25 2
24 22 26 1
25 22 27 1
26 24 28 2
27 26 29 1
28 29 30 1
29 29 31 1
30 17 20 1
31 19 23 1
32 25 28 1
33 32 33 1
34 32 41 2
35 32 45 1
36 33 34 1
37 33 46 1
38 41 40 1
39 41 42 1
40 45 44 2
41 34 35 2
42 34 39 1
43 46 47 1
44 42 43 2
45 35 36 1
46 39 38 2
47 47 48 1
48 47 52 1
49 36 37 2
50 48 49 1
51 49 50 1
52 49 51 1
53 40 35 1
54 44 43 1
55 38 37 1
BRACKET 1 16.1700 -23.1000 16.1700 -12.8100
1 25.8300 -12.8100 25.8300 -23.1000
1 2
ORIGINAL 1 11 12 15 20 24 28 25 21 17 13 18 23 19 14 16 22
1 26 29 30 31 27
REPEAT 1 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47
1 48 49 50 51 52
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