KEGG   DRUG: D02245Help
Entry
D02245                      Drug                                   

Name
Alimemazine tartrate (JP16);
Trimeprazine tartrate (USP);
Alimezine (TN)
Formula
(C18H22N2S)2. C4H6O6
Exact mass
746.3172
Mol weight
746.9782
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipruritic
Remark
Therapeutic category: 
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Phenothiazines
Histamine H1 receptor antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4413  Phenothiazines
     D02245  Alimemazine tartrate (JP16); Trimeprazine tartrate (USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD01 Alimemazine
      D02245  Alimemazine tartrate (JP16); Trimeprazine tartrate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Alimemazine [ATC:R06AD01]
      D02245  Trimeprazine tartrate (USP)
BRITE hierarchy
Other DBs
CAS: 
4330-99-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        52
            1   C1c C    31.5967  -17.3868
            2   C1c C    30.3821  -18.0876
            3   C6a C    32.8114  -18.0876
            4   O1a O    31.5909  -15.9795
            5   C6a C    29.1733  -17.3868
            6   O1a O    30.3762  -19.4892
            7   O6a O    34.0202  -17.3868
            8   O6a O    32.7997  -19.4892
            9   O6a O    27.9587  -18.0876
            10  O6a O    29.1674  -15.9795
            11  C8y C    19.4170  -19.9845
            12  N1y N    20.6259  -19.2895
            13  C8y C    19.4170  -21.3684
            14  C8x C    18.2140  -19.2895
            15  C8y C    21.8404  -19.9845
            16  C1b C    20.6259  -17.8646
            17  S2x S    20.6259  -22.0809
            18  C8x C    18.2140  -22.0634
            19  C8x C    17.0053  -20.0019
            20  C8y C    21.8404  -21.3860
            21  C8x C    23.0609  -19.2895
            22  C1c C    21.8404  -17.1638
            23  C8x C    17.0053  -21.3684
            24  C8x C    23.0609  -22.0809
            25  C8x C    24.2757  -19.9845
            26  C1b C    21.8404  -15.7624
            27  C1a C    23.0609  -17.8822
            28  C8x C    24.2757  -21.3684
            29  N1c N    23.0609  -15.0734
            30  C1a C    24.2757  -15.7856
            31  C1a C    23.0609  -13.6718
            32  C8y C    19.4170  -19.9845
            33  N1y N    20.6259  -19.2895
            34  C8y C    21.8404  -19.9845
            35  C8y C    21.8404  -21.3860
            36  C8x C    23.0609  -22.0809
            37  C8x C    24.2757  -21.3684
            38  C8x C    24.2757  -19.9845
            39  C8x C    23.0609  -19.2895
            40  S2x S    20.6259  -22.0809
            41  C8y C    19.4170  -21.3684
            42  C8x C    18.2140  -22.0634
            43  C8x C    17.0053  -21.3684
            44  C8x C    17.0053  -20.0019
            45  C8x C    18.2140  -19.2895
            46  C1b C    20.6259  -17.8646
            47  C1c C    21.8404  -17.1638
            48  C1b C    21.8404  -15.7624
            49  N1c N    23.0609  -15.0734
            50  C1a C    24.2757  -15.7856
            51  C1a C    23.0609  -13.6718
            52  C1a C    23.0609  -17.8822
BOND        55
            1     2   6 1 #Up
            2     3   7 1
            3     3   8 2
            4     5   9 1
            5     5  10 2
            6     1   2 1
            7     1   3 1
            8     1   4 1 #Up
            9     2   5 1
            10   11  12 1
            11   11  13 2
            12   11  14 1
            13   12  15 1
            14   12  16 1
            15   13  17 1
            16   13  18 1
            17   14  19 2
            18   15  20 2
            19   15  21 1
            20   16  22 1
            21   18  23 2
            22   20  24 1
            23   21  25 2
            24   22  26 1
            25   22  27 1
            26   24  28 2
            27   26  29 1
            28   29  30 1
            29   29  31 1
            30   17  20 1
            31   19  23 1
            32   25  28 1
            33   32  33 1
            34   32  41 2
            35   32  45 1
            36   33  34 1
            37   33  46 1
            38   41  40 1
            39   41  42 1
            40   45  44 2
            41   34  35 2
            42   34  39 1
            43   46  47 1
            44   42  43 2
            45   35  36 1
            46   39  38 2
            47   47  48 1
            48   47  52 1
            49   36  37 2
            50   48  49 1
            51   49  50 1
            52   49  51 1
            53   40  35 1
            54   44  43 1
            55   38  37 1
BRACKET     1    16.1700  -23.1000   16.1700  -12.8100
            1    25.8300  -12.8100   25.8300  -23.1000
            1  2
 ORIGINAL  1   11  12  15  20  24  28  25  21  17  13  18  23  19  14  16  22
            1   26  29  30  31  27
 REPEAT    1   32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47
            1   48  49  50  51  52

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