KEGG   DRUG: D02248Help
Entry
D02248                      Drug                                   

Name
Levomepromazine maleate (JP16/USAN);
Hirnamin (TN)
Formula
C19H24N2OS. C4H4O4
Exact mass
444.1719
Mol weight
444.5438
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Analgesic [central nervous system depressant]
Remark
Therapeutic category: 
ATC code: 
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Phenothiazines
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D02248  Levomepromazine maleate (JP16/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA02 Levomepromazine
      D02248  Levomepromazine maleate (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Levomepromazine [ATC:N05AA02]
      D02248  Levomepromazine maleate (JP16/USAN)
    alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
     Levomepromazine [ATC:N05AA02]
      D02248  Levomepromazine maleate (JP16/USAN)
   Dopamine
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Levomepromazine [ATC:N05AA02]
      D02248  Levomepromazine maleate (JP16/USAN)
   Serotonin
    5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
     Levomepromazine [ATC:N05AA02]
      D02248  Levomepromazine maleate (JP16/USAN)
BRITE hierarchy
Other DBs
CAS: 
7104-38-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C8x C    16.1381  -21.1212
            2   C8x C    16.1381  -22.5253
            3   C8x C    17.3549  -23.2272
            4   C8x C    17.3549  -20.4194
            5   C8y C    18.5248  -21.1212
            6   C8y C    18.5248  -22.5253
            7   S2x S    19.7416  -23.2272
            8   N1y N    19.6948  -20.4194
            9   C8y C    20.9584  -21.1212
            10  C8y C    20.9584  -22.5253
            11  C8x C    22.1751  -23.2741
            12  C8x C    23.3921  -22.5720
            13  C8y C    23.3920  -21.1681
            14  C8x C    22.1751  -20.4661
            15  C1b C    19.6948  -19.0153
            16  C1c C    20.9584  -18.3601
            17  C1b C    20.9584  -16.9561
            18  C1a C    22.1285  -19.0621
            19  N1c N    22.1752  -16.2540
            20  C1a C    22.1752  -14.8502
            21  C1a C    23.3921  -16.9561
            22  O2a O    24.6138  -20.4624
            23  C1a C    25.8005  -21.1474
            24  C6a C    33.8311  -21.1375
            25  C2b C    33.1345  -19.9301
            26  O6a O    33.1345  -22.2987
            27  O6a O    35.1780  -21.1375
            28  C2b C    31.5090  -19.9301
            29  C6a C    30.8124  -21.1375
            30  O6a O    29.4654  -21.1375
            31  O6a O    31.5090  -22.2987
BOND        32
            1    14   9 1
            2     2   3 2
            3     5   6 2
            4     6   7 1
            5     8  15 1
            6     7  10 1
            7    15  16 1
            8     9   8 1
            9    16  17 1
            10    8   5 1
            11   16  18 1 #Up
            12    3   6 1
            13   17  19 1
            14    5   4 1
            15   19  20 1
            16    4   1 2
            17   19  21 1
            18    1   2 1
            19    9  10 2
            20   10  11 1
            21   11  12 2
            22   12  13 1
            23   13  14 2
            24   13  22 1
            25   22  23 1
            26   24  25 1
            27   24  26 1
            28   24  27 2
            29   25  28 2
            30   28  29 1
            31   29  30 1
            32   29  31 2

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