KEGG   DRUG: D02260Help
Entry
D02260                      Drug                                   
Name
Paroxetine hydrochloride hydrate (JAN);
Paxil (TN)
Product
  Generic
PAROXETINE (Aurolife Pharma LLC), PAROXETINE (NCS HealthCare of KY), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (STAT Rx USA LLC), PAROXETINE (American Health Packaging), PAROXETINE (Aurobindo Pharma Limited), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Cardinal Health), PAROXETINE (Golden State Medical Supply), PAROXETINE (H.J. Harkins Company), PAROXETINE (International Labs), PAROXETINE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (McKesson Contract Packaging), PAROXETINE HYDROCHLORIDE (Mylan Institutional), PAROXETINE HYDROCHLORIDE (Mylan Pharmaceuticals), PAROXETINE HYDROCHLORIDE (Physicians Total Care), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE (Rebel Distributors Corp), PAROXETINE (STAT Rx USA LLC), PAROXETINE (Zydus Pharmaceuticals (USA)), PAROXETINE (Cardinal Health), PAROXETINE (Mylan Institutional), PAROXETINE (Mylan Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (State of Florida DOH Central Pharmacy)
Formula
(C19H20FNO3. HCl)2. H2O
Exact mass
748.2494
Mol weight
749.668
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Therapeutic category: 
ATC code: 
Comment
Selective serotonin reuptake inhibitor (SSRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: ABCB1 [HSA:5243]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D02260  Paroxetine hydrochloride hydrate (JAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D02260  Paroxetine hydrochloride hydrate (JAN)
USP drug classification [BR:br08302]
 Antidepressants
  Serotonin / Norepinephrine Reuptake Inhibitors
   Paroxetine
    D02260  Paroxetine hydrochloride hydrate (JAN)
 Anxiolytics
  SSRIs / SNRIs (Selective Serotonin Reuptake Inhibitors / Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02260  Paroxetine hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
     Paroxetine [ATC:N06AB05]
      D02260  Paroxetine hydrochloride hydrate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        51
            1   O0  O    41.1566  -17.6442
            2   C1y C    33.8100  -18.5500
            3   C1y C    32.5500  -19.2500
            4   C8y C    33.8100  -17.1500
            5   C1x C    35.0000  -19.2500
            6   C1b C    31.3600  -18.5500
            7   C1x C    32.5500  -20.6500
            8   C8x C    35.0000  -16.4500
            9   C8x C    32.5500  -16.4500
            10  C1x C    35.0000  -20.6500
            11  O2a O    30.1700  -19.2500
            12  N1x N    33.8100  -21.3500
            13  C8x C    35.0000  -15.0500
            14  C8x C    32.5500  -15.0500
            15  C8y C    28.9100  -18.5500
            16  C8y C    33.8100  -14.3500
            17  C8x C    28.9100  -17.1500
            18  C8x C    27.7200  -19.2500
            19  X   F    33.8100  -12.9500
            20  C8y C    27.7200  -16.4500
            21  C8x C    26.5300  -18.5500
            22  C8y C    26.5300  -17.1500
            23  O2x O    27.4400  -15.1200
            24  O2x O    25.4800  -16.2400
            25  C1x C    26.0400  -14.9100
            26  X   Cl   37.7300  -17.5700
            27  C1y C    33.8100  -18.5500
            28  C1y C    32.5500  -19.2500
            29  C1b C    31.3600  -18.5500
            30  O2a O    30.1700  -19.2500
            31  C8y C    28.9100  -18.5500
            32  C8x C    28.9100  -17.1500
            33  C8y C    27.7200  -16.4500
            34  C8y C    26.5300  -17.1500
            35  C8x C    26.5300  -18.5500
            36  C8x C    27.7200  -19.2500
            37  O2x O    25.4800  -16.2400
            38  C1x C    26.0400  -14.9100
            39  O2x O    27.4400  -15.1200
            40  C1x C    32.5500  -20.6500
            41  N1x N    33.8100  -21.3500
            42  C1x C    35.0000  -20.6500
            43  C1x C    35.0000  -19.2500
            44  C8y C    33.8100  -17.1500
            45  C8x C    35.0000  -16.4500
            46  C8x C    35.0000  -15.0500
            47  C8y C    33.8100  -14.3500
            48  C8x C    32.5500  -15.0500
            49  C8x C    32.5500  -16.4500
            50  X   F    33.8100  -12.9500
            51  X   Cl   37.7300  -17.5700
BOND        54
            1    14  16 1
            2    21  22 1
            3    24  25 1
            4     2   3 1
            5     2   4 1 #Down
            6     2   5 1
            7     3   6 1 #Up
            8     3   7 1
            9     4   8 2
            10    4   9 1
            11    5  10 1
            12    6  11 1
            13    7  12 1
            14    8  13 1
            15    9  14 2
            16   11  15 1
            17   13  16 2
            18   15  17 2
            19   15  18 1
            20   16  19 1
            21   17  20 1
            22   18  21 2
            23   20  22 2
            24   20  23 1
            25   22  24 1
            26   23  25 1
            27   10  12 1
            28   48  47 1
            29   35  34 1
            30   37  38 1
            31   27  28 1
            32   27  44 1 #Down
            33   27  43 1
            34   28  29 1 #Up
            35   28  40 1
            36   44  45 2
            37   44  49 1
            38   43  42 1
            39   29  30 1
            40   40  41 1
            41   45  46 1
            42   49  48 2
            43   30  31 1
            44   46  47 2
            45   31  32 2
            46   31  36 1
            47   47  50 1
            48   32  33 1
            49   36  35 2
            50   33  34 2
            51   33  39 1
            52   34  37 1
            53   39  38 1
            54   42  41 1
BRACKET     1    25.0600  -22.8200   25.0600  -12.2500
            1    38.5000  -12.2500   38.5000  -22.8200
            1  2
 ORIGINAL  1    2   3   6  11  15  17  20  22  21  18  24  25  23   7  12  10
            1    5   4   8  13  16  14   9  19  26
 REPEAT    1   27  28  29  30  31  32  33  34  35  36  37  38  39  40  41  42
            1   43  44  45  46  47  48  49  50  51

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