KEGG   DRUG: D02282Help
Entry
D02282                      Drug                                   

Name
Rolitetracycline (JAN/USAN/INN);
Synterin (TN)
Formula
C27H33N3O8
Exact mass
527.2268
Mol weight
527.5662
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
ATC code: 
Drug group: 
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA09 Rolitetracycline
      D02282  Rolitetracycline (JAN/USAN/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Rolitetracycline
      D02282  Rolitetracycline (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
751-97-3
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        38
            1   C8x C    23.7013  -16.7748
            2   C8x C    23.7013  -18.2161
            3   C8y C    24.9101  -18.9135
            4   C8x C    24.9101  -16.0774
            5   C8y C    26.1190  -16.7748
            6   C8y C    26.1190  -18.2161
            7   C5x C    27.3278  -18.9135
            8   C1z C    27.3278  -16.0774
            9   C1y C    28.5367  -16.8213
            10  C2y C    28.5367  -18.2161
            11  C2y C    29.7456  -18.9135
            12  C1x C    29.7920  -16.1239
            13  C1y C    30.9544  -16.8213
            14  C1z C    30.9544  -18.2161
            15  C5x C    32.1633  -18.9135
            16  C2y C    33.3721  -18.2626
            17  C2y C    33.3721  -16.8678
            18  C1y C    32.2097  -16.1239
            19  C5a C    34.5810  -18.9601
            20  N1b N    35.7899  -18.2626
            21  C1b C    36.9987  -18.9601
            22  N1y N    38.2075  -18.2626
            23  C1x C    39.5505  -18.7120
            24  C1x C    40.3926  -17.6157
            25  C1x C    39.5937  -16.4224
            26  C1x C    38.2306  -16.8621
            27  N1c N    32.2097  -14.7290
            28  C1a C    33.4186  -14.0782
            29  C1a C    31.0009  -14.0316
            30  C1a C    27.8858  -14.5889
            31  O1a O    26.6305  -14.5889
            32  O1a O    24.9101  -20.3084
            33  O5x O    27.3278  -20.3084
            34  O1a O    29.7456  -20.3084
            35  O5x O    32.1633  -20.3549
            36  O5a O    34.5810  -20.3549
            37  O1a O    34.6275  -16.1704
            38  O1a O    30.9544  -19.6109
BOND        42
            1     5   4 2
            2    21  22 1
            3     4   1 1
            4     9  10 1
            5    10  11 2
            6    22  23 1
            7    23  24 1
            8    24  25 1
            9    25  26 1
            10   26  22 1
            11   11  14 1
            12   18  27 1 #Down
            13   13  12 1
            14   27  28 1
            15   12   9 1
            16   27  29 1
            17    1   2 2
            18    2   3 1
            19    8  30 1 #Down
            20    5   6 1
            21    8  31 1 #Up
            22    6   7 1
            23    3  32 1
            24    7  10 1
            25    7  33 2
            26   13  14 1
            27   11  34 1
            28   14  15 1
            29   15  35 2
            30   15  16 1
            31   19  36 2
            32   16  17 2
            33   17  37 1
            34   17  18 1
            35   14  38 1 #Down
            36   18  13 1
            37    9   8 1
            38   16  19 1
            39    8   5 1
            40   19  20 1
            41    3   6 2
            42   20  21 1

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