KEGG   DRUG: PefloxacinHelp
Entry
D02306                      Drug                                   

Name
Pefloxacin (USAN/INN);
PFLX
Formula
C17H20FN3O3
Exact mass
333.1489
Mol weight
333.3574
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
ATC code: 
Chemical group: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA03 Pefloxacin
      D02306  Pefloxacin (USAN/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Pefloxacin
      D02306  Pefloxacin (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Pefloxacin
    D02306  Pefloxacin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
70458-92-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    23.3537  -16.5170
            2   C8y C    23.3537  -15.1174
            3   C8x C    22.1406  -14.4175
            4   C8y C    20.9276  -15.1174
            5   C8y C    20.9276  -16.5170
            6   C8x C    22.1406  -17.2169
            7   N4y N    24.5658  -17.2169
            8   C8x C    25.7779  -16.5170
            9   C8y C    25.7779  -15.1174
            10  C8y C    24.5658  -14.4175
            11  O5x O    24.5658  -13.0178
            12  C6a C    26.9915  -14.4167
            13  O6a O    28.2050  -15.1174
            14  O6a O    26.9915  -13.0178
            15  X   F    19.7155  -14.4173
            16  N1y N    19.7155  -17.2171
            17  C1x C    18.5024  -16.5169
            18  C1x C    17.2904  -17.2170
            19  N1y N    17.2906  -18.6167
            20  C1x C    18.5037  -19.3168
            21  C1x C    19.7157  -18.6168
            22  C1a C    16.0770  -19.3176
            23  C1b C    24.5658  -18.6166
            24  C1a C    23.3543  -19.3160
BOND        26
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    2  10 1
            12   10  11 2
            13    9  12 1
            14   12  13 1
            15   12  14 2
            16    4  15 1
            17    5  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   16  21 1
            24   19  22 1
            25    7  23 1
            26   23  24 1

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