KEGG   DRUG: D02349Help
Entry
D02349                      Drug                                   

Name
Dipivefrin (USAN);
Dipivefrine (INN)
Formula
C19H29NO5
Exact mass
351.2046
Mol weight
351.4373
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Adrenergic [ophthalmic]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
prodrug, active substance: Epinephrine [DR:D00095]
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA02 Dipivefrine
      D02349  Dipivefrin (USAN); Dipivefrine (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Dipivefrin
    D02349  Dipivefrin (USAN); Dipivefrine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Dipivefrine
      D02349  Dipivefrin (USAN); Dipivefrine (INN)
    alpha2-adrenergic receptor
     Dipivefrine
      D02349  Dipivefrin (USAN); Dipivefrine (INN)
    beta1-adrenergic receptor
     Dipivefrine
      D02349  Dipivefrin (USAN); Dipivefrine (INN)
    beta2-adrenergic receptor
     Dipivefrine
      D02349  Dipivefrin (USAN); Dipivefrine (INN)
    beta3-adrenergic receptor
     Dipivefrine
      D02349  Dipivefrin (USAN); Dipivefrine (INN)
BRITE hierarchy
Other DBs
CAS: 
52365-63-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8y C    10.7100  -23.0300
            2   C8y C    10.7100  -24.4300
            3   C8x C    11.9000  -22.3300
            4   O7a O     9.5200  -22.3300
            5   C8x C    11.9700  -25.0600
            6   O7a O     9.5900  -25.0600
            7   C8y C    13.1600  -22.9600
            8   C7a C     9.5200  -21.0000
            9   C8x C    13.1600  -24.3600
            10  C1c C    14.3500  -22.2600
            11  C1d C     8.2600  -20.3000
            12  O6a O    10.7100  -20.2300
            13  C1b C    15.5400  -22.8900
            14  O1a O    14.3500  -20.8600
            15  N1b N    16.7394  -22.1679
            16  C1a C    17.9665  -22.8466
            17  C7a C     9.5900  -26.4600
            18  C1d C     8.3776  -27.1600
            19  O6a O    10.8024  -27.1600
            20  C1a C     7.1821  -26.4696
            21  C1a C     8.3775  -28.5598
            22  C1a C     7.1820  -27.8503
            23  C1a C     7.0593  -21.0199
            24  C1a C     8.2369  -18.9002
            25  C1a C     7.0362  -19.6201
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    8  11 1
            11    8  12 2
            12   10  13 1
            13   10  14 1
            14    7   9 2
            15   13  15 1
            16   15  16 1
            17    6  17 1
            18   17  18 1
            19   17  19 2
            20   18  20 1
            21   18  21 1
            22   18  22 1
            23   11  23 1
            24   11  24 1
            25   11  25 1

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