KEGG   DRUG: D02358Help
Entry
D02358                      Drug                                   

Name
Metoprolol (USAN/INN)
Formula
C15H25NO3
Exact mass
267.1834
Mol weight
267.3639
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [beta-receptor]
Remark
Same as: 
ATC code: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antiarrhythmic drugs
Antimigraines
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB02 Metoprolol
      D02358  Metoprolol (USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Metoprolol
    D02358  Metoprolol (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Metoprolol [ATC:C07AB02]
      D02358  Metoprolol (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
51384-51-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8y C    17.9937  -12.8132
            2   C8x C    16.7834  -13.5115
            3   C8x C    17.9937  -11.4166
            4   O2a O    19.1982  -13.5115
            5   C8x C    15.5672  -12.8132
            6   C8x C    16.7834  -10.7125
            7   C1b C    20.4086  -12.8132
            8   C8y C    15.5672  -11.4166
            9   C1c C    21.6248  -13.5056
            10  C1b C    14.3570  -10.7125
            11  C1b C    22.8350  -12.8132
            12  O1a O    21.6248  -14.9080
            13  C1b C    13.1409  -11.4166
            14  N1b N    24.0512  -13.5056
            15  O2a O    11.9304  -10.7125
            16  C1c C    25.2615  -12.8072
            17  C1a C    10.6735  -11.4574
            18  C1a C    26.4776  -13.5056
            19  C1a C    25.2615  -11.4574
BOND        19
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     7   9 1
            9     8  10 1
            10    9  11 1
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   16  19 1
            19    6   8 1

» Japanese version   » Back

DBGET integrated database retrieval system