KEGG   DRUG: ParoxetineHelp
Entry
D02362                      Drug                                   

Name
Paroxetine (USP/INN);
Paroxetine (TN)
Formula
C19H20FNO3
Exact mass
329.1427
Mol weight
329.3654
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor
Cyp substrate
 DG01644  CYP2D6 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Transporter substrate
 DG01665  P-glycoprotein substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antidepressant, SSRI
Comment
Selective serotonin reuptake inhibitor (SSRI)
Fluoxetine derivative
Target
serotonin transporter [HSA:6532] [KO:K05037]
  Pathway
Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: ABCB1 [HSA:5243]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D02362  Paroxetine (USP/INN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02362  Paroxetine (USP/INN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02362  Paroxetine (USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Paroxetine
      D02362  Paroxetine (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Paroxetine
    D02362  Paroxetine (USP/INN)
 CYP substrates
  CYP2D6
   Paroxetine
    D02362  Paroxetine (USP/INN)
 Transporter substrates
  ABCB1
   Paroxetine
    D02362  Paroxetine (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
61869-08-7
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C1y C    24.7626  -18.6745
            2   C1y C    23.5491  -19.3721
            3   C8y C    24.7684  -17.3611
            4   C1x C    25.9759  -19.3721
            5   C1b C    22.3356  -18.6745
            6   C1x C    23.5491  -20.7791
            7   C8x C    25.9819  -16.6634
            8   C8x C    23.5549  -16.6634
            9   C1x C    25.9759  -20.7791
            10  O2a O    21.1161  -19.3721
            11  N1x N    24.7626  -21.4766
            12  C8x C    25.9819  -15.2624
            13  C8x C    23.5549  -15.2566
            14  C8y C    19.9026  -18.6686
            15  C8y C    24.7684  -14.5589
            16  C8x C    19.9086  -17.2733
            17  C8x C    18.6951  -19.3781
            18  X   F    24.7743  -13.2982
            19  C8y C    18.7008  -16.5699
            20  C8x C    17.4816  -18.6745
            21  C8y C    17.4816  -17.2733
            22  O2x O    18.4137  -15.1456
            23  O2x O    16.4848  -16.2829
            24  C1x C    16.9657  -14.8996
BOND        27
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1

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