KEGG   DRUG: D02362Help
Entry
D02362                      Drug                                   

Name
Paroxetine (USP/INN);
Paroxetine (TN)
Formula
C19H20FNO3
Exact mass
329.1427
Mol weight
329.3654
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Selective serotonin reuptake inhibitor (SSRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: ABCB1 [HSA:5243]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D02362  Paroxetine (USP/INN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02362  Paroxetine (USP/INN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02362  Paroxetine (USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Paroxetine
      D02362  Paroxetine (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Paroxetine
    D02362  Paroxetine (USP/INN)
 Inhbitors
  CYP2D6
   Paroxetine
    D02362  Paroxetine (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
61869-08-7
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C1y C    24.7626  -18.6745
            2   C1y C    23.5491  -19.3721
            3   C8y C    24.7684  -17.3611
            4   C1x C    25.9759  -19.3721
            5   C1b C    22.3356  -18.6745
            6   C1x C    23.5491  -20.7791
            7   C8x C    25.9819  -16.6634
            8   C8x C    23.5549  -16.6634
            9   C1x C    25.9759  -20.7791
            10  O2a O    21.1161  -19.3721
            11  N1x N    24.7626  -21.4766
            12  C8x C    25.9819  -15.2624
            13  C8x C    23.5549  -15.2566
            14  C8y C    19.9026  -18.6686
            15  C8y C    24.7684  -14.5589
            16  C8x C    19.9086  -17.2733
            17  C8x C    18.6951  -19.3781
            18  X   F    24.7743  -13.2982
            19  C8y C    18.7008  -16.5699
            20  C8x C    17.4816  -18.6745
            21  C8y C    17.4816  -17.2733
            22  O2x O    18.4137  -15.1456
            23  O2x O    16.4848  -16.2829
            24  C1x C    16.9657  -14.8996
BOND        27
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1

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