| Entry |
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| Name |
Metipranolol (USAN/INN)
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| Product |
|
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| Generic |
|
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| Formula |
C17H27NO4
|
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| Exact mass |
309.194
|
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| Mol weight |
309.4006
|
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| Structure |
     |
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| Activity |
Antihypertensive [beta-blocker, ophthalmic] [DS: H00612]
|
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| Remark |
|
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| Comment |
Indication: Open angle glaucoma
|
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| Target |
beta1-adrenergic receptor antagonist [HSA: 153] [KO: K04141]; beta2-adrenergic receptor antagonist [HSA: 154] [KO: K04142]; beta3-adrenergic receptor antagonist [HSA: 155] [KO: K04143] |
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| Pathway |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01ED Beta blocking agents
S01ED04 Metipranolol
D02374 Metipranolol (USAN/INN)
USP drug classification [BR:br08302]
Ophthalmic Agents
Ophthalmic Antiglaucoma Agents
Beta-Adrenergic Blocking Agents, Ophthalmic
Metipranolol
D02374 Metipranolol (USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
beta1-adrenergic receptor [HSA:153] [KO:K04141]
Metipranolol [ATC:S01ED04]
D02374 Metipranolol (USAN/INN)
beta2-adrenergic receptor [HSA:154] [KO:K04142]
Metipranolol [ATC:S01ED04]
D02374 Metipranolol (USAN/INN)
beta3-adrenergic receptor [HSA:155] [KO:K04143]
Metipranolol [ATC:S01ED04]
D02374 Metipranolol (USAN/INN)
 |
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| Other DBs |
CAS: 22664-55-7 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 22
1 C8y C 20.0200 -20.5100
2 C8y C 20.0200 -21.9100
3 C8y C 21.2324 -22.6100
4 C8y C 22.4449 -21.9100
5 C8x C 22.4449 -20.5100
6 C8y C 21.2324 -19.8100
7 C1a C 21.2324 -18.4102
8 C1a C 21.2324 -24.0098
9 C1a C 18.8076 -22.6100
10 O7a O 18.8076 -19.8100
11 C7a C 17.6121 -20.5004
12 C1a C 16.4247 -19.8149
13 O6a O 17.6120 -21.9097
14 O2a O 23.6760 -22.6210
15 C1b C 24.8812 -21.9253
16 C1c C 26.0635 -22.6081
17 C1b C 27.2575 -21.9188
18 O1a O 26.0635 -24.0098
19 N1b N 28.4454 -22.6048
20 C1c C 29.6365 -21.9171
21 C1a C 30.8259 -22.6039
22 C1a C 29.6367 -20.5103
BOND 22
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 3 8 1
9 2 9 1
10 1 10 1
11 10 11 1
12 11 12 1
13 11 13 2
14 4 14 1
15 14 15 1
16 15 16 1
17 16 17 1
18 16 18 1
19 17 19 1
20 19 20 1
21 20 21 1
22 20 22 1
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