KEGG   DRUG: D02374Help
Entry
D02374                      Drug                                   

Name
Metipranolol (USAN/INN)
Product
  Generic
Formula
C17H27NO4
Exact mass
309.194
Mol weight
309.4006
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive [beta-blocker, ophthalmic] [DS:H00612]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Indication: Open angle glaucoma
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED04 Metipranolol
      D02374  Metipranolol (USAN/INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Metipranolol
    D02374  Metipranolol (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Metipranolol
      D02374  Metipranolol (USAN/INN)
    beta2-adrenergic receptor
     Metipranolol
      D02374  Metipranolol (USAN/INN)
    beta3-adrenergic receptor
     Metipranolol
      D02374  Metipranolol (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
22664-55-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   O2a O    18.6900  -13.9300
            2   C1b C    19.8800  -13.2300
            3   C1c C    21.0000  -13.9300
            4   C1b C    22.1900  -13.2300
            5   O1a O    21.0000  -15.4000
            6   N1b N    23.3800  -13.9300
            7   C1c C    24.5700  -13.2300
            8   C1a C    25.8300  -13.9300
            9   C1a C    24.5700  -11.7600
            10  C8y C    18.6900  -15.4000
            11  C8y C    17.5000  -16.1000
            12  C8y C    17.5000  -17.5000
            13  C8y C    18.6900  -18.2000
            14  C8y C    19.8800  -17.5000
            15  C8x C    19.8800  -16.1000
            16  C1a C    21.1400  -18.2000
            17  O7a O    18.6900  -19.6000
            18  C7a C    17.5000  -20.3000
            19  C1a C    16.2400  -18.2000
            20  C1a C    16.2400  -19.6000
            21  O6a O    17.5000  -21.7000
            22  C1a C    16.2400  -15.4000
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 1
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     7   9 1
            9     1  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   10  15 1
            16   14  16 1
            17   13  17 1
            18   17  18 1
            19   12  19 1
            20   18  20 1
            21   18  21 2
            22   11  22 1

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