KEGG   DRUG: D02374Help
Entry
D02374                      Drug                                   

Name
Metipranolol (USAN/INN)
Product
  Generic
Formula
C17H27NO4
Exact mass
309.194
Mol weight
309.4006
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive [beta-blocker, ophthalmic] [DS:H00612]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Indication: Open angle glaucoma
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED04 Metipranolol
      D02374  Metipranolol (USAN/INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Metipranolol
    D02374  Metipranolol (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Metipranolol
      D02374  Metipranolol (USAN/INN)
    beta2-adrenergic receptor
     Metipranolol
      D02374  Metipranolol (USAN/INN)
    beta3-adrenergic receptor
     Metipranolol
      D02374  Metipranolol (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
22664-55-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    20.0200  -20.5100
            2   C8y C    20.0200  -21.9100
            3   C8y C    21.2324  -22.6100
            4   C8y C    22.4449  -21.9100
            5   C8x C    22.4449  -20.5100
            6   C8y C    21.2324  -19.8100
            7   C1a C    21.2324  -18.4102
            8   C1a C    21.2324  -24.0098
            9   C1a C    18.8076  -22.6100
            10  O7a O    18.8076  -19.8100
            11  C7a C    17.6121  -20.5004
            12  C1a C    16.4247  -19.8149
            13  O6a O    17.6120  -21.9097
            14  O2a O    23.6760  -22.6210
            15  C1b C    24.8812  -21.9253
            16  C1c C    26.0635  -22.6081
            17  C1b C    27.2575  -21.9188
            18  O1a O    26.0635  -24.0098
            19  N1b N    28.4454  -22.6048
            20  C1c C    29.6365  -21.9171
            21  C1a C    30.8259  -22.6039
            22  C1a C    29.6367  -20.5103
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     3   8 1
            9     2   9 1
            10    1  10 1
            11   10  11 1
            12   11  12 1
            13   11  13 2
            14    4  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   16  18 1
            19   17  19 1
            20   19  20 1
            21   20  21 1
            22   20  22 1

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