KEGG   DRUG: TerbinafineHelp
Entry
D02375                      Drug                                   

Name
Terbinafine (USAN/INN);
Lamasil (TN)
Formula
C21H25N
Exact mass
291.1987
Mol weight
291.4299
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01634  CYP1A2 inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Allylamine derivative
Target
squalene epoxidase [KO:K00511]
  Pathway
Steroid biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2C8 [HSA:1558], CYP2C19 [HSA:1557]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565], CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antifungal agents
Naphthalene family
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AE Other antifungals for topical use
     D01AE15 Terbinafine
      D02375  Terbinafine (USAN/INN)
   D01B ANTIFUNGALS FOR SYSTEMIC USE
    D01BA Antifungals for systemic use
     D01BA02 Terbinafine
      D02375  Terbinafine (USAN/INN)
USP drug classification [BR:br08302]
 Antifungals
  Terbinafine
   D02375  Terbinafine (USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Terbinafine
    D02375  Terbinafine (USAN/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Terbinafine
    D02375  Terbinafine (USAN/INN)
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   squalene epoxidase inhibitor
    Allylamines
     Terbinafine
      D02375  Terbinafine (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Terbinafine
    D02375  Terbinafine (USAN/INN)
  CYP2D6
   Terbinafine
    D02375  Terbinafine (USAN/INN)
 CYP substrates
  CYP1A2
   Terbinafine
    D02375  Terbinafine (USAN/INN)
  CYP2C8
   Terbinafine
    D02375  Terbinafine (USAN/INN)
  CYP2C9
   Terbinafine
    D02375  Terbinafine (USAN/INN)
  CYP2C19
   Terbinafine
    D02375  Terbinafine (USAN/INN)
  CYP3A4
   Terbinafine
    D02375  Terbinafine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
91161-71-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8x C     5.7400  -17.9200
            2   C8x C     5.7400  -19.3200
            3   C8x C     6.9524  -20.0200
            4   C8y C     8.1649  -19.3200
            5   C8y C     8.1649  -17.9200
            6   C8x C     6.9524  -17.2200
            7   C8x C     9.3773  -20.0200
            8   C8x C    10.5897  -19.3200
            9   C8x C    10.5897  -17.9200
            10  C8y C     9.3773  -17.2200
            11  C1b C     9.3773  -15.8200
            12  N1c N    10.5918  -15.1188
            13  C1b C    11.7883  -15.8098
            14  C1a C    10.5918  -13.7202
            15  C2b C    12.9751  -15.1246
            16  C2b C    14.1666  -15.8128
            17  C3b C    15.3560  -15.1261
            18  C3b C    16.5684  -14.4261
            19  C1d C    17.7808  -13.7261
            20  C1a C    18.9933  -13.0261
            21  C1a C    17.0780  -12.5087
            22  C1a C    18.4780  -14.9336
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   12  14 1
            16   13  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 3
            20   18  19 1
            21   19  20 1
            22   19  21 1
            23   19  22 1

» Japanese version   » Back

DBGET integrated database retrieval system