| Entry |
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| Name |
Primidolol (USAN/INN)
|
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| Formula |
C17H23N3O4
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| Exact mass |
333.1689
|
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| Mol weight |
333.3822
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| Structure |
     |
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| Activity |
Antihypertensive;
Anti-anginal;
Cardiac depressant [anti-arrhythmic]
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| Remark |
|
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| Target |
beta1-adrenergic receptor antagonist [HSA: 153] [KO: K04141]; beta2-adrenergic receptor antagonist [HSA: 154] [KO: K04142]; beta3-adrenergic receptor antagonist [HSA: 155] [KO: K04143] |
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| Pathway |
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| Interaction |
|
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| Brite |
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
beta1-adrenergic receptor [HSA:153] [KO:K04141]
Primidolol
D02389 Primidolol (USAN/INN)
beta2-adrenergic receptor [HSA:154] [KO:K04142]
Primidolol
D02389 Primidolol (USAN/INN)
beta3-adrenergic receptor [HSA:155] [KO:K04143]
Primidolol
D02389 Primidolol (USAN/INN)
 |
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| Other DBs |
CAS: 67227-55-8 PubChem: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 24
1 C8x C 19.3795 -21.0989
2 C8x C 19.3736 -19.6906
3 C8x C 18.1641 -21.8000
4 C8y C 18.1641 -18.9895
5 C8x C 16.9489 -21.0929
6 C8y C 16.9489 -19.6906
7 C1a C 15.7336 -18.9895
8 O2a O 18.0954 -17.5916
9 C1b C 19.3768 -16.8938
10 C1c C 20.5868 -17.5941
11 C1b C 21.7981 -16.8964
12 N1b N 23.0079 -17.5965
13 C1b C 24.2193 -16.8989
14 C1b C 25.4293 -17.5990
15 O1a O 20.5853 -18.9920
16 N4y N 26.6381 -16.9004
17 C8x C 27.8504 -17.6016
18 C8y C 29.0638 -16.9021
19 C8y C 29.0648 -15.5017
20 N4x N 27.8525 -14.8005
21 C8y C 26.6391 -15.5000
22 C1a C 30.2740 -17.6019
23 O5x O 25.4289 -14.8002
24 O5x O 30.2760 -14.8036
BOND 25
1 11 12 1
2 4 6 2
3 12 13 1
4 6 7 1
5 13 14 1
6 14 16 1
7 5 6 1
8 15 10 1
9 4 8 1
10 1 2 2
11 8 9 1
12 1 3 1
13 9 10 1
14 16 17 1
15 17 18 2
16 18 19 1
17 19 20 1
18 20 21 1
19 21 16 1
20 2 4 1
21 18 22 1
22 10 11 1
23 21 23 2
24 3 5 2
25 19 24 2
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