KEGG   DRUG: D02419Help
Entry
D02419                      Drug                                   

Name
Diphenhydramine salicylate (JAN)
Formula
C17H21NO. C7H6O3
Exact mass
393.194
Mol weight
393.4755
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
Same as: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Hypnotics
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA32 Diphenhydramine
      D02419  Diphenhydramine salicylate (JAN)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AA Aminoalkyl ethers
     R06AA02 Diphenhydramine
      D02419  Diphenhydramine salicylate (JAN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Diphenhydramine
    D02419  Diphenhydramine salicylate (JAN)
 Antiparkinson Agents
  Anticholinergics
   Diphenhydramine
    D02419  Diphenhydramine salicylate (JAN)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Diphenhydramine
    D02419  Diphenhydramine salicylate (JAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D02419  Diphenhydramine salicylate (JAN)
 Allergic agents
  52 Antihistamine based drugs
   D02419  Diphenhydramine salicylate (JAN)
  -- Allergic agents (oral use)
   D02419  Diphenhydramine salicylate (JAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Diphenhydramine
    D02419  Diphenhydramine salicylate (JAN)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Diphenhydramine
    D02419  Diphenhydramine salicylate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Diphenhydramine
      D02419  Diphenhydramine salicylate (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Diphenhydramine
    D02419  Diphenhydramine salicylate (JAN)
 Inhbitors
  CYP2D6
   Diphenhydramine
    D02419  Diphenhydramine salicylate (JAN)
BRITE hierarchy
Other DBs
CAS: 
7491-10-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8y C    35.4176  -17.2194
            2   C8y C    36.6305  -17.9191
            3   C8x C    34.2047  -17.9191
            4   C6a C    35.4176  -15.8198
            5   C8x C    36.6305  -19.3186
            6   O1a O    37.8433  -17.2194
            7   C8x C    34.2047  -19.3186
            8   O6a O    36.6305  -15.1201
            9   O6a O    34.2047  -15.1201
            10  C8x C    35.4176  -20.0183
            11  C1c C    26.8347  -17.2856
            12  C8y C    25.6239  -17.9899
            13  C8y C    28.0515  -17.9899
            14  O2a O    26.8406  -15.8884
            15  C8x C    25.6239  -19.3930
            16  C8x C    24.4130  -17.2856
            17  C8x C    28.0458  -19.3930
            18  C8x C    29.2565  -17.2856
            19  C1b C    28.0515  -15.1840
            20  C8x C    24.4130  -20.0856
            21  C8x C    23.1962  -17.9899
            22  C8x C    29.2565  -20.0856
            23  C8x C    30.4732  -17.9899
            24  C8x C    23.1962  -19.3930
            25  C8x C    30.4673  -19.3930
            26  C1b C    29.2874  -15.8950
            27  N1c N    30.4839  -15.2016
            28  C1a C    31.6732  -15.8857
            29  C1a C    30.4817  -13.7927
BOND        30
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    7  10 2
            11   15  20 2
            12   16  21 1
            13   17  22 1
            14   18  23 2
            15   20  24 1
            16   22  25 2
            17   21  24 2
            18   23  25 1
            19   11  12 1
            20   11  13 1
            21   11  14 1
            22   12  15 1
            23   12  16 2
            24   13  17 2
            25   13  18 1
            26   14  19 1
            27   19  26 1
            28   26  27 1
            29   27  28 1
            30   27  29 1

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