KEGG   DRUG: D02420Help
Entry
D02420                      Drug                                   

Name
Acetylspiramycin (JP16);
Spiramycin II;
A-SPM;
Acetylspiramycin (TN)
Formula
C45H76N2O15
Exact mass
884.5246
Mol weight
885.0893
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Component of Spiramycin [DR:D05908]
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA02 Spiramycin
      D02420  Acetylspiramycin (JP16)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6142  Spiramycin antibiotics
     D02420  Acetylspiramycin (JP16)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Spiramycin
      D02420  Acetylspiramycin (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02420  Acetylspiramycin
BRITE hierarchy
Other DBs
CAS: 
24916-51-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        62
            1   C1y C    24.3265  -27.0478
            2   C1y C    25.4421  -27.7004
            3   O2a O    23.2154  -27.7004
            4   C1y C    24.3265  -25.7661
            5   C1y C    26.5700  -27.0478
            6   N1c N    25.4421  -28.9890
            7   C1y C    22.1055  -28.3418
            8   O2x O    25.4421  -25.1247
            9   C1a C    23.2212  -25.1247
            10  C1y C    26.5700  -25.7661
            11  O1a O    27.6868  -27.7004
            12  C1a C    26.5586  -29.6292
            13  C1a C    24.3322  -29.6292
            14  C1x C    22.1055  -29.6234
            15  O2x O    20.9775  -27.7004
            16  O2a O    28.8199  -23.1440
            17  C1z C    20.9775  -30.2761
            18  C1y C    19.8618  -28.3418
            19  C1y C    25.3798  -19.4577
            20  C1y C    19.8618  -29.6234
            21  C1a C    20.1076  -31.5066
            22  O1a O    21.8826  -31.6670
            23  C1a C    18.7566  -27.7004
            24  C1y C    25.4442  -18.1352
            25  C1y C    24.2872  -20.1276
            26  O1a O    18.7566  -30.2761
            27  C1x C    24.2234  -17.4882
            28  C1b C    26.4783  -17.4824
            29  C1y C    24.3162  -21.5188
            30  O2a O    23.1882  -19.6318
            31  C1y C    24.2234  -16.1895
            32  C4a C    27.6007  -18.1182
            33  C1x C    23.0954  -22.1142
            34  C1y C    23.0896  -15.5481
            35  C1a C    25.3333  -15.5425
            36  O4a O    28.7106  -17.4654
            37  C7x C    21.9273  -21.4672
            38  C2x C    21.9797  -16.1895
            39  O2a O    23.0896  -14.2673
            40  O7x O    20.7607  -22.1086
            41  O6a O    21.9273  -20.1788
            42  C2x C    21.9797  -17.4882
            43  C1y C    19.6100  -21.4091
            44  C2x C    20.8403  -18.1352
            45  C1x C    19.5930  -20.0467
            46  C1a C    18.5228  -22.0743
            47  C2x C    20.8699  -19.4406
            48  C1a C    23.1778  -18.3494
            49  O7a O    25.4175  -22.1938
            50  C7a C    25.4187  -23.4138
            51  O6a O    26.5970  -24.0927
            52  C1a C    24.2882  -24.0947
            53  C1y C    21.9804  -13.6269
            54  O2x O    21.9844  -12.3512
            55  C1y C    20.8751  -11.7107
            56  C1y C    19.7659  -12.3512
            57  C1x C    19.7659  -13.6320
            58  C1x C    20.8751  -14.2724
            59  C1a C    20.8751  -10.4299
            60  N1c N    18.6567  -11.7107
            61  C1a C    18.6567  -10.4299
            62  C1a C    17.5474  -12.3512
BOND        65
            1    19  25 1
            2    20  26 1 #Up
            3    24  27 1
            4    24  28 1 #Down
            5    25  29 1
            6    25  30 1 #Down
            7    27  31 1
            8    28  32 1
            9    29  33 1
            10   31  34 1
            11   31  35 1 #Down
            12   32  36 2
            13   33  37 1
            14   34  38 1
            15   34  39 1 #Down
            16   37  40 1
            17   37  41 2
            18   38  42 2
            19   40  43 1
            20   42  44 1
            21   43  45 1
            22   43  46 1 #Down
            23   44  47 2
            24    8  10 1
            25   18  20 1
            26   45  47 1
            27   30  48 1
            28    1   2 1
            29    1   3 1 #Down
            30    1   4 1
            31    2   5 1
            32    2   6 1 #Up
            33    7   3 1 #Up
            34    4   8 1
            35    4   9 1 #Up
            36    5  10 1
            37    5  11 1 #Down
            38    6  12 1
            39   29  49 1 #Down
            40    6  13 1
            41   49  50 1
            42    7  14 1
            43   50  51 2
            44    7  15 1
            45   50  52 1
            46   53  39 1 #Up
            47   10  16 1 #Up
            48   14  17 1
            49   15  18 1
            50   19  16 1 #Down
            51   17  20 1
            52   53  54 1
            53   54  55 1
            54   55  56 1
            55   56  57 1
            56   57  58 1
            57   58  53 1
            58   17  21 1 #Down
            59   55  59 1 #Up
            60   17  22 1 #Up
            61   56  60 1 #Down
            62   18  23 1 #Down
            63   60  61 1
            64   19  24 1
            65   60  62 1

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