KEGG   DRUG: D02487Help
Entry
D02487                      Drug                                   

Name
Proguanil hydrochloride (JAN);
Chloroguanide hydrochloride;
Paludrine (TN)
Formula
C11H16ClN5. HCl
Exact mass
289.0861
Mol weight
290.1922
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiprotozoal, antimalarial [DS:H00361]
Remark
ATC code: 
Drug group: 
Target
dihydrofolate reductase inhibitor [KO:K13998]
  Pathway
ko00240  Pyrimidine metabolism
ko00670  One carbon pool by folate
ko00790  Folate biosynthesis  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01B ANTIMALARIALS
    P01BB Biguanides
     P01BB01 Proguanil
      D02487  Proguanil hydrochloride (JAN)
Antiinfectives [BR:br08307]
 Antiparasitics
  Antmalarials
   dihydrofolate reductase inhibitor
    Biguanides
     Proguanil
      D02487  Proguanil hydrochloride (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Proguanil
    D02487  Proguanil hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
637-32-1
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        18
            1   X   Cl   30.2397  -16.7532
            2   C8x C    16.2400  -16.0300
            3   C8y C    16.2400  -17.4300
            4   C8x C    17.4300  -18.1300
            5   C8x C    18.6200  -17.4300
            6   C8y C    18.6200  -16.0300
            7   C8x C    17.4300  -15.3300
            8   X   Cl   14.9800  -18.1300
            9   N1b N    19.8800  -15.3300
            10  C2c C    21.0700  -16.0300
            11  N1b N    22.2600  -15.3300
            12  N2a N    21.0700  -17.4300
            13  C2c C    23.4500  -16.0300
            14  N1b N    24.7100  -15.3300
            15  N2a N    23.4500  -17.4300
            16  C1c C    25.9000  -16.0300
            17  C1a C    27.0900  -15.3300
            18  C1a C    25.9000  -17.4300
BOND        17
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     3   8 1
            8     6   9 1
            9     9  10 1
            10   10  11 1
            11   10  12 2
            12   11  13 1
            13   13  14 1
            14   13  15 2
            15   14  16 1
            16   16  17 1
            17   16  18 1

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