KEGG   DRUG: D02490Help
Entry
D02490                      Drug                                   

Name
Tylosin (USP/INN);
TS;
Tylan (TN)
Formula
C46H77NO17
Exact mass
915.5192
Mol weight
916.1001
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
0 Mtk  1 Mtd  2 Mtd  3 Man  4 Mte  5 Etk  6 Mtk  7 Man
  Type
PK
Source
Streptomyces fradiae [TAX:1906]
Activity
Antibacterial, veterinary
Remark
Same as: 
Drug group: 
Comment
Natural product
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Structure map
Macrolides and ketolides
Brite
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Tylosin; Veterinary
      D02490  Tylosin (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
1401-69-0
PubChem: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        64
            1   C2x C    16.8389  -11.7742
            2   C2x C    16.8389  -13.1787
            3   C1x C    19.2969  -13.1787
            4   C1y C    19.2969  -11.7742
            5   C5x C    18.0328  -11.0720
            6   C1y C    19.2969  -15.9877
            7   C1y C    20.4907  -15.2855
            8   C1y C    20.4907  -13.8810
            9   C2y C    15.6451  -13.8810
            10  C2x C    15.6451  -15.2855
            11  C7x C    16.8389  -17.3922
            12  C1x C    18.0328  -18.0944
            13  C1y C    19.2969  -17.3922
            14  C1y C    14.3811  -15.9877
            15  C1y C    14.3811  -17.3922
            16  O7x O    15.6451  -18.0944
            17  O6a O    16.8389  -15.9877
            18  O1a O    20.4907  -18.0944
            19  O2a O    21.6845  -15.9877
            20  C1b C    21.6845  -13.1787
            21  C4a C    22.8784  -13.8810
            22  O4a O    24.0722  -13.1787
            23  C1a C    20.4907  -11.0720
            24  O5x O    18.0328   -9.6675
            25  C1a C    14.4513  -13.1787
            26  C1b C    13.1873  -15.2855
            27  O2a O    11.9232  -15.9877
            28  C1y C    10.7294  -15.2152
            29  O2x O    10.7294  -13.8107
            30  C1y C     9.5356  -13.1085
            31  C1y C     8.2715  -13.8107
            32  C1y C     8.2715  -15.2152
            33  C1y C     9.5356  -15.9175
            34  C1b C    13.1873  -18.0944
            35  C1a C    11.9934  -17.3922
            36  C1a C    18.1030  -15.2855
            37  C1a C     9.5356  -11.7040
            38  O1a O     7.0777  -13.1085
            39  O2a O     7.0777  -15.9175
            40  C1a C     5.8839  -15.2152
            41  O2a O     9.5356  -17.3220
            42  C1a C     8.3418  -18.0242
            43  C1y C    22.8784  -16.6900
            44  C1y C    22.8784  -18.0944
            45  C1y C    24.0722  -18.7967
            46  C1y C    25.3362  -18.0944
            47  C1y C    25.3362  -16.6900
            48  O2x O    24.0722  -15.9877
            49  O1a O    21.6845  -18.7967
            50  O2a O    26.5300  -18.7967
            51  C1a C    26.5300  -15.9877
            52  N1c N    24.0722  -20.2013
            53  C1a C    22.8784  -20.9035
            54  C1a C    25.2660  -20.9035
            55  C1y C    27.7941  -19.4990
            56  C1x C    27.7941  -20.9035
            57  C1z C    28.9879  -21.6058
            58  C1y C    30.1817  -20.9035
            59  C1y C    30.1817  -19.4990
            60  O2x O    28.9879  -18.7967
            61  C1a C    31.3755  -18.7967
            62  C1a C    29.9710  -22.5889
            63  O1a O    28.1452  -22.7294
            64  O1a O    31.3755  -21.6058
BOND        67
            1     1   2 2
            2     3   4 1
            3     4   5 1
            4     1   5 1
            5     6   7 1
            6     7   8 1
            7     3   8 1
            8     2   9 1
            9     9  10 2
            10   11  12 1
            11   12  13 1
            12   13   6 1
            13   10  14 1
            14   14  15 1
            15   15  16 1
            16   11  16 1
            17   11  17 2
            18   13  18 1 #Down
            19    7  19 1 #Down
            20    8  20 1 #Down
            21   20  21 1
            22   21  22 2
            23    4  23 1 #Down
            24    5  24 2
            25    9  25 1
            26   14  26 1 #Up
            27   26  27 1
            28   28  27 1 #Up
            29   28  29 1
            30   29  30 1
            31   30  31 1
            32   31  32 1
            33   32  33 1
            34   28  33 1
            35   15  34 1 #Down
            36   34  35 1
            37    6  36 1 #Down
            38   30  37 1 #Up
            39   31  38 1 #Down
            40   32  39 1 #Down
            41   39  40 1
            42   33  41 1 #Down
            43   41  42 1
            44   43  44 1
            45   44  45 1
            46   45  46 1
            47   46  47 1
            48   47  48 1
            49   43  48 1
            50   44  49 1 #Up
            51   46  50 1 #Up
            52   47  51 1 #Down
            53   43  19 1 #Down
            54   45  52 1 #Down
            55   52  53 1
            56   52  54 1
            57   55  50 1 #Down
            58   55  56 1
            59   56  57 1
            60   57  58 1
            61   58  59 1
            62   59  60 1
            63   55  60 1
            64   59  61 1 #Up
            65   57  62 1 #Up
            66   57  63 1 #Down
            67   58  64 1 #Down

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