KEGG   DRUG: D02497Help
Entry
D02497                      Drug                                   

Name
Fosamprenavir (INN)
Formula
C25H36N3O9PS
Exact mass
585.191
Mol weight
585.6068
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral [HIV protease inhibitor] [DS:H00406]
Remark
ATC code: 
Drug group: 
Comment
prodrug, active substance: Amprenavir [DR:D00894]
Target
HIV protease inhibitor [CPD:C19849]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565], CYP1A2 [HSA:1544], CYP2C9 [HSA:1559]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Anti-HIV agents
HIV protease inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AE Protease inhibitors
     J05AE07 Fosamprenavir
      D02497  Fosamprenavir (INN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Protease Inhibitors
   Fosamprenavir
    D02497  Fosamprenavir (INN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Protease inhibitor (PIs)
    Nonpeptidic
     Fosamprenavir
      D02497  Fosamprenavir (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Fosamprenavir
    D02497  Fosamprenavir (INN)
  CYP2C9
   Fosamprenavir
    D02497  Fosamprenavir (INN)
  CYP2D6
   Fosamprenavir
    D02497  Fosamprenavir (INN)
  CYP3A4
   Fosamprenavir
    D02497  Fosamprenavir (INN)
 Inhbitors
  CYP3A
   Fosamprenavir
    D02497  Fosamprenavir (INN)
BRITE hierarchy
Other DBs
CAS: 
226700-79-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        39
            1   N1c N    16.3800   -7.8400
            2   C1b C    15.2600   -7.1400
            3   S4a S    17.9200   -7.1400
            4   C1c C    14.0700   -7.8400
            5   C8y C    19.3200   -7.8400
            6   C1c C    12.8800   -7.1400
            7   N1b N    11.7600   -7.8400
            8   C7a C    10.5700   -7.1400
            9   O7a O     9.3800   -7.8400
            10  O6a O    10.5700   -5.8100
            11  C1y C     8.1900   -7.2100
            12  C8x C    19.3200   -9.2400
            13  C8x C    20.5100   -9.8700
            14  C8y C    21.6300   -9.2400
            15  C8x C    21.6300   -7.8400
            16  C8x C    20.5100   -7.1400
            17  N1a N    22.8900   -9.9400
            18  O2b O    14.0700   -9.8700
            19  P1b P    12.8800  -10.6400
            20  O1c O    11.7600  -11.2700
            21  O3c O    16.9400   -6.2300
            22  O3c O    18.8300   -6.2300
            23  O1c O    13.5800  -11.8300
            24  O1c O    12.1800   -9.4500
            25  C1x C     8.1900   -5.8800
            26  C1x C     6.9300   -7.6300
            27  C1x C     6.0900   -6.5800
            28  O2x O     6.9300   -5.4600
            29  C1b C    16.3577   -9.2370
            30  C1c C    17.5765   -9.9669
            31  C1a C    18.8063   -9.2830
            32  C1a C    17.5543  -11.3399
            33  C1b C    12.8612   -5.7401
            34  C8y C    14.0780   -5.0156
            35  C8x C    15.3039   -5.7014
            36  C8x C    16.5068   -4.9850
            37  C8x C    16.4878   -3.5852
            38  C8x C    15.2619   -2.8993
            39  C8x C    14.0590   -3.6157
BOND        41
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     8  10 2
            10   11   9 1 #Up
            11    5  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16    5  16 1
            17   14  17 1
            18    4  18 1 #Up
            19   18  19 1
            20   19  20 1
            21    3  21 2
            22    3  22 2
            23   19  23 1
            24   19  24 2
            25   11  25 1
            26   11  26 1
            27   26  27 1
            28   27  28 1
            29   25  28 1
            30    1  29 1
            31   29  30 1
            32   30  31 1
            33   30  32 1
            34    6  33 1 #Up
            35   33  34 1
            36   34  35 2
            37   35  36 1
            38   36  37 2
            39   37  38 1
            40   38  39 2
            41   34  39 1

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