KEGG   DRUG: D02523Help
Entry
D02523                      Drug                                   

Name
Erythromycin acistrate (USAN);
EA;
Erasis (TN)
Formula
C39H69NO14. C18H36O2
Exact mass
1059.7433
Mol weight
1060.4407
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
ATC code: 
Drug group: 
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02523  Erythromycin acistrate (USAN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02523  Erythromycin acistrate (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02523  Erythromycin acistrate (USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Erythromycin
      D02523  Erythromycin acistrate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
  CYP3A5
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
  CYP3A7
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
 Inhbitors
  CYP2C19
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
  CYP3A4
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
  CYP3A7
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
  CYP3A
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
BRITE hierarchy
Other DBs
CAS: 
96128-89-1
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        74
            1   C1y C    14.7668  -16.0137
            2   C1z C    14.7668  -14.6627
            3   C1y C    13.5933  -16.6836
            4   O2a O    16.7304  -16.7236
            5   C1x C    13.5933  -13.9871
            6   O1a O    15.7858  -13.6837
            7   C1a C    16.0377  -15.0919
            8   C1y C    13.5933  -18.0347
            9   C1a C    12.6312  -15.6710
            10  C1y C    13.5933  -12.6303
            11  O2a O    14.3261  -19.3800
            12  C1y C    12.4311  -18.7103
            13  C5x C    12.4311  -11.9604
            14  C1a C    14.7668  -11.9604
            15  C1y C    15.4817  -21.9450
            16  C7x C    11.2575  -18.0347
            17  C1a C    12.4311  -20.0612
            18  C1y C    11.2575  -12.6303
            19  O5x O    12.4311  -10.6093
            20  C1x C    15.4817  -23.2903
            21  O2x O    16.6554  -21.2695
            22  O7x O    11.2575  -16.6836
            23  O6a O    10.2098  -18.9736
            24  C1y C    11.2575  -13.9871
            25  C1a C    10.0897  -11.9604
            26  C1z C    16.6554  -23.9716
            27  C1y C    17.8174  -21.9450
            28  C1y C    10.0897  -16.0137
            29  C1z C    10.0897  -14.6627
            30  O1a O    12.4311  -14.6627
            31  C1y C    17.8174  -23.2903
            32  O2a O    16.6554  -25.2827
            33  C1a C    18.0866  -24.9449
            34  C1b C     8.9217  -16.6836
            35  C1a C     8.8531  -15.2235
            36  O1a O     8.8531  -13.9815
            37  O1a O    18.9911  -23.9716
            38  C1a C    17.7431  -26.2331
            39  C1a C     8.9564  -17.7941
            40  C1a C    19.0133  -21.2569
            41  C1y C    17.7947  -15.8268
            42  C1y C    18.5255  -17.0533
            43  C1y C    19.9130  -17.0606
            44  C1x C    20.6132  -15.8626
            45  C1y C    19.9091  -14.6279
            46  O2x O    18.5215  -14.6205
            47  C1a C    20.6149  -13.4203
            48  O7a O    17.8402  -18.2516
            49  C7a C    17.7907  -19.6049
            50  O6a O    16.5869  -20.2428
            51  C1a C    18.9868  -20.3552
            52  N1c N    20.5878  -18.2437
            53  C1a C    20.5758  -19.6051
            54  C1a C    21.9432  -17.8911
            55  C6a C    24.8960  -23.4904
            56  C1b C    26.0977  -24.1842
            57  O6a O    23.6944  -24.1842
            58  C1b C    27.2826  -23.4999
            59  C1b C    28.4594  -24.1794
            60  C1b C    29.6400  -23.4975
            61  C1b C    30.8190  -24.1781
            62  C1b C    31.9985  -23.4969
            63  C1b C    33.1781  -24.1778
            64  C1b C    34.3573  -23.4967
            65  C1b C    35.5370  -24.1777
            66  C1b C    36.7162  -23.4966
            67  C1b C    37.8958  -24.1777
            68  C1b C    39.0751  -23.4966
            69  C1b C    40.2547  -24.1777
            70  C1b C    41.4340  -23.4966
            71  C1b C    42.6136  -24.1777
            72  C1b C    43.7928  -23.4966
            73  C1a C    44.9725  -24.1777
            74  O6a O    24.8960  -22.1029
BOND        75
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     5  10 1
            10    8  11 1 #Down
            11    8  12 1
            12   10  13 1
            13   10  14 1 #Down
            14   15  11 1 #Down
            15   12  16 1
            16   12  17 1 #Up
            17   13  18 1
            18   13  19 2
            19   15  20 1
            20   15  21 1
            21   16  22 1
            22   16  23 2
            23   18  24 1
            24   18  25 1 #Up
            25   20  26 1
            26   21  27 1
            27   22  28 1
            28   24  29 1
            29   24  30 1 #Up
            30   26  31 1
            31   26  32 1 #Down
            32   26  33 1
            33   28  34 1 #Down
            34   29  35 1 #Down
            35   29  36 1 #Up
            36   31  37 1 #Down
            37   32  38 1
            38   34  39 1
            39   27  31 1
            40   28  29 1
            41   27  40 1 #Up
            42   41   4 1 #Down
            43   41  42 1
            44   42  43 1
            45   43  44 1
            46   44  45 1
            47   45  46 1
            48   41  46 1
            49   45  47 1 #Down
            50   42  48 1 #Up
            51   48  49 1
            52   49  50 2
            53   49  51 1
            54   43  52 1 #Down
            55   52  53 1
            56   52  54 1
            57   55  56 1
            58   55  57 1
            59   56  58 1
            60   58  59 1
            61   59  60 1
            62   60  61 1
            63   61  62 1
            64   62  63 1
            65   63  64 1
            66   64  65 1
            67   65  66 1
            68   66  67 1
            69   67  68 1
            70   68  69 1
            71   69  70 1
            72   70  71 1
            73   71  72 1
            74   72  73 1
            75   55  74 2

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