KEGG   DRUG: D02523Help
Entry
D02523                      Drug                                   

Name
Erythromycin acistrate (USAN);
EA;
Erasis (TN)
Formula
C39H69NO14. C18H36O2
Exact mass
1059.7433
Mol weight
1060.4407
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D02523  Erythromycin acistrate (USAN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02523  Erythromycin acistrate (USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D02523  Erythromycin acistrate (USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D02523  Erythromycin acistrate (USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Macrolides
     Erythromycin [ATC:D10AF02 J01FA01 S01AA17]
      D02523  Erythromycin acistrate (USAN)
BRITE hierarchy
Other DBs
CAS: 
96128-89-1
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        74
            1   C1y C    14.7668  -16.0137
            2   C1z C    14.7668  -14.6627
            3   C1y C    13.5933  -16.6836
            4   O2a O    16.7304  -16.7236
            5   C1x C    13.5933  -13.9871
            6   O1a O    15.7858  -13.6837
            7   C1a C    16.0377  -15.0919
            8   C1y C    13.5933  -18.0347
            9   C1a C    12.6312  -15.6710
            10  C1y C    13.5933  -12.6303
            11  O2a O    14.3261  -19.3800
            12  C1y C    12.4311  -18.7103
            13  C5x C    12.4311  -11.9604
            14  C1a C    14.7668  -11.9604
            15  C1y C    15.4817  -21.9450
            16  C7x C    11.2575  -18.0347
            17  C1a C    12.4311  -20.0612
            18  C1y C    11.2575  -12.6303
            19  O5x O    12.4311  -10.6093
            20  C1x C    15.4817  -23.2903
            21  O2x O    16.6554  -21.2695
            22  O7x O    11.2575  -16.6836
            23  O6a O    10.2098  -18.9736
            24  C1y C    11.2575  -13.9871
            25  C1a C    10.0897  -11.9604
            26  C1z C    16.6554  -23.9716
            27  C1y C    17.8174  -21.9450
            28  C1y C    10.0897  -16.0137
            29  C1z C    10.0897  -14.6627
            30  O1a O    12.4311  -14.6627
            31  C1y C    17.8174  -23.2903
            32  O2a O    16.6554  -25.2827
            33  C1a C    18.0866  -24.9449
            34  C1b C     8.9217  -16.6836
            35  C1a C     8.8531  -15.2235
            36  O1a O     8.8531  -13.9815
            37  O1a O    18.9911  -23.9716
            38  C1a C    17.7431  -26.2331
            39  C1a C     8.9564  -17.7941
            40  C1a C    19.0133  -21.2569
            41  C1y C    17.7947  -15.8268
            42  C1y C    18.5255  -17.0533
            43  C1y C    19.9130  -17.0606
            44  C1x C    20.6132  -15.8626
            45  C1y C    19.9091  -14.6279
            46  O2x O    18.5215  -14.6205
            47  C1a C    20.6149  -13.4203
            48  O7a O    17.8402  -18.2516
            49  C7a C    17.7907  -19.6049
            50  O6a O    16.5869  -20.2428
            51  C1a C    18.9868  -20.3552
            52  N1c N    20.5878  -18.2437
            53  C1a C    20.5758  -19.6051
            54  C1a C    21.9432  -17.8911
            55  C6a C    24.8960  -23.4904
            56  C1b C    26.0977  -24.1842
            57  O6a O    23.6944  -24.1842
            58  C1b C    27.2826  -23.4999
            59  C1b C    28.4594  -24.1794
            60  C1b C    29.6400  -23.4975
            61  C1b C    30.8190  -24.1781
            62  C1b C    31.9985  -23.4969
            63  C1b C    33.1781  -24.1778
            64  C1b C    34.3573  -23.4967
            65  C1b C    35.5370  -24.1777
            66  C1b C    36.7162  -23.4966
            67  C1b C    37.8958  -24.1777
            68  C1b C    39.0751  -23.4966
            69  C1b C    40.2547  -24.1777
            70  C1b C    41.4340  -23.4966
            71  C1b C    42.6136  -24.1777
            72  C1b C    43.7928  -23.4966
            73  C1a C    44.9725  -24.1777
            74  O6a O    24.8960  -22.1029
BOND        75
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     5  10 1
            10    8  11 1 #Down
            11    8  12 1
            12   10  13 1
            13   10  14 1 #Down
            14   15  11 1 #Down
            15   12  16 1
            16   12  17 1 #Up
            17   13  18 1
            18   13  19 2
            19   15  20 1
            20   15  21 1
            21   16  22 1
            22   16  23 2
            23   18  24 1
            24   18  25 1 #Up
            25   20  26 1
            26   21  27 1
            27   22  28 1
            28   24  29 1
            29   24  30 1 #Up
            30   26  31 1
            31   26  32 1 #Down
            32   26  33 1
            33   28  34 1 #Down
            34   29  35 1 #Down
            35   29  36 1 #Up
            36   31  37 1 #Down
            37   32  38 1
            38   34  39 1
            39   27  31 1
            40   28  29 1
            41   27  40 1 #Up
            42   41   4 1 #Down
            43   41  42 1
            44   42  43 1
            45   43  44 1
            46   44  45 1
            47   45  46 1
            48   41  46 1
            49   45  47 1 #Down
            50   42  48 1 #Up
            51   48  49 1
            52   49  50 2
            53   49  51 1
            54   43  52 1 #Down
            55   52  53 1
            56   52  54 1
            57   55  56 1
            58   55  57 1
            59   56  58 1
            60   58  59 1
            61   59  60 1
            62   60  61 1
            63   61  62 1
            64   62  63 1
            65   63  64 1
            66   64  65 1
            67   65  66 1
            68   66  67 1
            69   67  68 1
            70   68  69 1
            71   69  70 1
            72   70  71 1
            73   71  72 1
            74   72  73 1
            75   55  74 2

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