KEGG   DRUG: D02525Help
Entry
D02525                      Drug                                   

Name
Erythromycin propionate (USAN)
Formula
C40H71NO14
Exact mass
789.4875
Mol weight
789.99
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
ATC code: 
Drug group: 
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D02525  Erythromycin propionate (USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D02525  Erythromycin propionate (USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Erythromycin
      D02525  Erythromycin propionate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Erythromycin
    D02525  Erythromycin propionate (USAN)
  CYP3A5
   Erythromycin
    D02525  Erythromycin propionate (USAN)
  CYP3A7
   Erythromycin
    D02525  Erythromycin propionate (USAN)
 Inhbitors
  CYP2C19
   Erythromycin
    D02525  Erythromycin propionate (USAN)
  CYP3A4
   Erythromycin
    D02525  Erythromycin propionate (USAN)
  CYP3A7
   Erythromycin
    D02525  Erythromycin propionate (USAN)
  CYP3A
   Erythromycin
    D02525  Erythromycin propionate (USAN)
BRITE hierarchy
Other DBs
CAS: 
134-36-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        55
            1   C1y C    27.5803  -10.5165
            2   C1z C    27.5803   -9.1533
            3   C1y C    26.3962  -11.1924
            4   O2a O    30.1215  -11.5828
            5   C1x C    26.3962   -8.4717
            6   O1a O    28.6084   -8.1656
            7   C1a C    28.8626   -9.5864
            8   C1y C    26.3962  -12.5556
            9   C1a C    25.4255  -10.1707
            10  C1y C    31.3493   -8.8380
            11  C1y C    26.3962   -7.1027
            12  O2a O    27.1356  -13.9130
            13  C1y C    25.2236  -13.2373
            14  C1y C    32.5174   -9.5292
            15  O2x O    31.3613   -7.4753
            16  C5x C    25.2236   -6.4268
            17  C1a C    27.5803   -6.4268
            18  C1y C    28.6516  -14.3309
            19  C7x C    24.0395  -12.5556
            20  C1a C    25.2236  -14.6003
            21  C1y C    33.7729   -8.8676
            22  O7a O    32.5783  -11.7369
            23  C1y C    32.5517   -6.8110
            24  C1y C    24.0395   -7.1027
            25  O5x O    25.2236   -5.0636
            26  C1x C    28.6516  -15.6884
            27  O2x O    29.8358  -13.6494
            28  O7x O    24.0395  -11.1924
            29  O6a O    22.9824  -13.5029
            30  C1x C    33.7173   -7.5100
            31  N1c N    34.8758   -9.5560
            32  C1a C    32.5714   -5.4505
            33  C1y C    24.0395   -8.4717
            34  C1a C    22.8612   -6.4268
            35  C1z C    29.8358  -16.3758
            36  C1y C    31.0082  -14.3309
            37  C1y C    22.8612  -10.5165
            38  C1z C    22.8612   -9.1533
            39  O1a O    25.2236   -9.1533
            40  C1y C    31.0082  -15.6884
            41  O2a O    29.8358  -17.6986
            42  C1a C    31.2798  -17.3578
            43  C1a C    32.1924  -13.6552
            44  C1b C    21.6827  -11.1924
            45  C1a C    21.6135   -9.7192
            46  O1a O    21.6135   -8.4660
            47  O1a O    32.1924  -16.3758
            48  C1a C    30.9332  -18.6575
            49  C1a C    21.7177  -12.3129
            50  C1a C    36.1221   -8.8485
            51  C7a C    33.7745  -12.4386
            52  O6a O    33.7745  -13.8386
            53  C1b C    34.9542  -11.7630
            54  C1a C    36.1447  -12.4561
            55  C1a C    34.8758  -10.9560
BOND        57
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   22  51 1
            54   51  52 2
            55   51  53 1
            56   53  54 1
            57   31  55 1

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