KEGG   DRUG: Garenoxacin mesylateHelp
Entry
D02540                      Drug                                   

Name
Garenoxacin mesylate (USAN);
Garenoxacin mesilate hydrate (JAN)
Formula
C23H20F2N2O4. CH4SO3. H2O
Exact mass
540.1378
Mol weight
540.5336
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
Therapeutic category: 
ATC code: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Interaction
Transporter inhibition: SLCO1B1 [HSA:10599]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA19 Garenoxacin
      D02540  Garenoxacin mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D02540  Garenoxacin mesylate (USAN); Garenoxacin mesilate hydrate (JAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Garenoxacin
      D02540  Garenoxacin mesylate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Transporter inhibitors
  SLCO1B1
   Garenoxacin
    D02540  Garenoxacin mesylate (USAN)
Antibacterials [br08350.html]
 D02540
BRITE hierarchy
Other DBs
CAS: 
223652-90-2
PubChem: 
LigandBox: 
KCF data Show

ATOM        37
            1   C8y C    25.0251  -15.3102
            2   C8x C    25.0251  -13.9059
            3   C8x C    26.2188  -13.2037
            4   C8y C    27.4826  -13.9059
            5   C8y C    27.4826  -15.3102
            6   C8y C    26.2188  -16.0123
            7   C8y C    28.6763  -13.2037
            8   C8y C    29.8700  -13.9059
            9   C8x C    29.8700  -15.3102
            10  N4y N    28.6763  -16.0123
            11  O5x O    28.6763  -11.7994
            12  C8y C    23.8314  -16.0123
            13  C8x C    23.8314  -17.4166
            14  C8x C    22.5676  -18.1188
            15  C8y C    21.3739  -17.4166
            16  C8y C    21.3739  -16.0123
            17  C8x C    22.5676  -15.3102
            18  O2a O    26.2188  -18.2566
            19  C6a C    31.0636  -13.2037
            20  O6a O    32.2573  -13.9059
            21  O6a O    31.0636  -11.7994
            22  C1x C    20.0398  -15.5910
            23  N1x N    19.1972  -16.7145
            24  C1y C    20.0398  -17.8379
            25  C1a C    19.6185  -19.1720
            26  C1y C    28.6763  -17.4166
            27  C1x C    27.9742  -18.6103
            28  C1x C    29.3785  -18.6103
            29  C1c C    25.0244  -18.9467
            30  X   F    25.0244  -20.3467
            31  X   F    23.7968  -18.2376
            32  C1a C    34.7198  -15.6608
            33  S4a S    36.1241  -15.6608
            34  O1d O    36.1241  -17.0651
            35  O1d O    37.5284  -15.6608
            36  O1d O    36.1241  -14.2565
            37  O0  O    36.8418  -18.6706
BOND        39
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    7  11 2
            13    1  12 1
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   12  17 2
            20    6  18 1
            21    8  19 1
            22   19  20 1
            23   19  21 2
            24   16  22 1
            25   22  23 1
            26   23  24 1
            27   15  24 1
            28   24  25 1 #Up
            29   10  26 1
            30   27  28 1
            31   28  26 1
            32   26  27 1
            33   18  29 1
            34   29  30 1
            35   29  31 1
            36   32  33 1
            37   33  34 2
            38   33  35 1
            39   33  36 2

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