KEGG   DRUG: D02540Help
Entry
D02540                      Drug                                   

Name
Garenoxacin mesilate hydrate (JAN);
Garenoxacin mesylate (USAN)
Formula
C23H20F2N2O4. CH4SO3. H2O
Exact mass
540.1378
Mol weight
540.5336
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial agent
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Interaction
Transporter inhibition: SLCO1B1 [HSA:10599]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA19 Garenoxacin
      D02540  Garenoxacin mesilate hydrate (JAN); Garenoxacin mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D02540  Garenoxacin mesilate hydrate (JAN); Garenoxacin mesylate (USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Garenoxacin
      D02540  Garenoxacin mesilate hydrate (JAN); Garenoxacin mesylate (USAN)
BRITE hierarchy
Other DBs
CAS: 
223652-90-2
PubChem: 
LigandBox: 
KCF data Show

ATOM        37
            1   C8y C    25.0251  -15.3102
            2   C8x C    25.0251  -13.9059
            3   C8x C    26.2188  -13.2037
            4   C8y C    27.4826  -13.9059
            5   C8y C    27.4826  -15.3102
            6   C8y C    26.2188  -16.0123
            7   C8y C    28.6763  -13.2037
            8   C8y C    29.8700  -13.9059
            9   C8x C    29.8700  -15.3102
            10  N4y N    28.6763  -16.0123
            11  O5x O    28.6763  -11.7994
            12  C8y C    23.8314  -16.0123
            13  C8x C    23.8314  -17.4166
            14  C8x C    22.5676  -18.1188
            15  C8y C    21.3739  -17.4166
            16  C8y C    21.3739  -16.0123
            17  C8x C    22.5676  -15.3102
            18  O2a O    26.2188  -18.2566
            19  C6a C    31.0636  -13.2037
            20  O6a O    32.2573  -13.9059
            21  O6a O    31.0636  -11.7994
            22  C1x C    20.0398  -15.5910
            23  N1x N    19.1972  -16.7145
            24  C1y C    20.0398  -17.8379
            25  C1a C    19.6185  -19.1720
            26  C1y C    28.6763  -17.4166
            27  C1x C    27.9742  -18.6103
            28  C1x C    29.3785  -18.6103
            29  C1c C    25.0244  -18.9467
            30  X   F    25.0244  -20.3467
            31  X   F    23.7968  -18.2376
            32  C1a C    34.7198  -15.6608
            33  S4a S    36.1241  -15.6608
            34  O1d O    36.1241  -17.0651
            35  O1d O    37.5284  -15.6608
            36  O1d O    36.1241  -14.2565
            37  O0  O    36.8418  -18.6706
BOND        39
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    7  11 2
            13    1  12 1
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   12  17 2
            20    6  18 1
            21    8  19 1
            22   19  20 1
            23   19  21 2
            24   16  22 1
            25   22  23 1
            26   23  24 1
            27   15  24 1
            28   24  25 1 #Up
            29   10  26 1
            30   27  28 1
            31   28  26 1
            32   26  27 1
            33   18  29 1
            34   29  30 1
            35   29  31 1
            36   32  33 1
            37   33  34 2
            38   33  35 1
            39   33  36 2

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