KEGG   DRUG: D02542Help
Entry
D02542                      Drug                                   

Name
Tobramycin sulfate (USP);
Nebcin (TN)
Product
  Generic
Formula
(C18H37N5O9)2. 5H2SO4
Exact mass
1424.3552
Mol weight
1425.4214
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
ATC code: 
Drug group: 
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB01 Tobramycin
      D02542  Tobramycin sulfate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA12 Tobramycin
      D02542  Tobramycin sulfate (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Tobramycin
    D02542  Tobramycin sulfate (USP)
 Respiratory Tract/Pulmonary Agents
  Cystic Fibrosis Agents
   Tobramycin dry-powder inhaler
    D02542  Tobramycin sulfate (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Tobramycin
      D02542  Tobramycin sulfate (USP)
BRITE hierarchy
Other DBs
CAS: 
79645-27-5
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        89
            1   C1y C    16.6047  -20.3920
            2   C1y C    16.6047  -21.7937
            3   C1y C    17.7961  -22.4945
            4   C1y C    19.0576  -21.7937
            5   C1y C    19.0576  -20.3920
            6   O2x O    17.7961  -19.6912
            7   C1b C    15.4133  -19.6912
            8   O1a O    14.2218  -20.3920
            9   O1a O    15.4133  -22.4945
            10  N1a N    17.7961  -23.8962
            11  O1a O    20.2490  -22.4945
            12  O2a O    20.2490  -19.6912
            13  C1y C    21.4404  -18.9904
            14  C1y C    22.7019  -19.6912
            15  C1x C    23.8933  -18.9904
            16  C1y C    23.8933  -17.5887
            17  C1y C    22.6318  -16.8879
            18  C1y C    21.4404  -17.5887
            19  N1a N    22.7019  -21.0929
            20  N1a N    25.0146  -16.8879
            21  O1a O    20.2490  -16.8879
            22  O2a O    22.6318  -15.4862
            23  C1y C    23.8232  -14.7854
            24  O2x O    25.0847  -15.4862
            25  C1y C    26.2761  -14.7854
            26  C1y C    26.2761  -13.3838
            27  C1x C    25.0146  -12.6829
            28  C1y C    23.8232  -13.3838
            29  C1b C    27.5376  -15.4862
            30  N1a N    27.5376  -16.8879
            31  O1a O    27.4675  -12.6128
            32  N1a N    22.6318  -12.6829
            33  S4a S    33.9151  -18.7101
            34  O1d O    33.9151  -20.1117
            35  O1d O    33.9151  -17.3084
            36  O1d O    35.3168  -18.7101
            37  O1d O    32.5135  -18.7101
            38  C1y C    16.6047  -20.3920
            39  C1y C    16.6047  -21.7937
            40  C1y C    17.7961  -22.4945
            41  C1y C    19.0576  -21.7937
            42  C1y C    19.0576  -20.3920
            43  O2x O    17.7961  -19.6912
            44  O2a O    20.2490  -19.6912
            45  C1y C    21.4404  -18.9904
            46  C1y C    22.7019  -19.6912
            47  C1x C    23.8933  -18.9904
            48  C1y C    23.8933  -17.5887
            49  C1y C    22.6318  -16.8879
            50  C1y C    21.4404  -17.5887
            51  O1a O    20.2490  -16.8879
            52  O2a O    22.6318  -15.4862
            53  C1y C    23.8232  -14.7854
            54  O2x O    25.0847  -15.4862
            55  C1y C    26.2761  -14.7854
            56  C1y C    26.2761  -13.3838
            57  C1x C    25.0146  -12.6829
            58  C1y C    23.8232  -13.3838
            59  N1a N    22.6318  -12.6829
            60  O1a O    27.4675  -12.6128
            61  C1b C    27.5376  -15.4862
            62  N1a N    27.5376  -16.8879
            63  N1a N    25.0146  -16.8879
            64  N1a N    22.7019  -21.0929
            65  O1a O    20.2490  -22.4945
            66  N1a N    17.7961  -23.8962
            67  O1a O    15.4133  -22.4945
            68  C1b C    15.4133  -19.6912
            69  O1a O    14.2218  -20.3920
            70  S4a S    33.9151  -18.7101
            71  O1d O    33.9151  -20.1117
            72  O1d O    33.9151  -17.3084
            73  O1d O    35.3168  -18.7101
            74  O1d O    32.5135  -18.7101
            75  S4a S    33.9151  -18.7101
            76  O1d O    33.9151  -20.1117
            77  O1d O    33.9151  -17.3084
            78  O1d O    35.3168  -18.7101
            79  O1d O    32.5135  -18.7101
            80  S4a S    33.9151  -18.7101
            81  O1d O    33.9151  -20.1117
            82  O1d O    33.9151  -17.3084
            83  O1d O    35.3168  -18.7101
            84  O1d O    32.5135  -18.7101
            85  S4a S    33.9151  -18.7101
            86  O1d O    33.9151  -20.1117
            87  O1d O    33.9151  -17.3084
            88  O1d O    35.3168  -18.7101
            89  O1d O    32.5135  -18.7101
BOND        88
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1 #Up
            8     7   8 1
            9     2   9 1 #Down
            10    3  10 1 #Up
            11    4  11 1 #Down
            12    5  12 1 #Down
            13   13  12 1 #Down
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   13  18 1
            20   14  19 1 #Up
            21   16  20 1 #Up
            22   18  21 1 #Up
            23   17  22 1 #Down
            24   23  22 1 #Down
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   26  27 1
            29   27  28 1
            30   23  28 1
            31   25  29 1 #Up
            32   29  30 1
            33   26  31 1 #Down
            34   28  32 1 #Down
            35   38  39 1
            36   39  40 1
            37   40  41 1
            38   41  42 1
            39   42  43 1
            40   38  43 1
            41   38  68 1 #Up
            42   68  69 1
            43   39  67 1 #Down
            44   40  66 1 #Up
            45   41  65 1 #Down
            46   42  44 1 #Down
            47   45  44 1 #Down
            48   45  46 1
            49   46  47 1
            50   47  48 1
            51   48  49 1
            52   49  50 1
            53   45  50 1
            54   46  64 1 #Up
            55   48  63 1 #Up
            56   50  51 1 #Up
            57   49  52 1 #Down
            58   53  52 1 #Down
            59   53  54 1
            60   54  55 1
            61   55  56 1
            62   56  57 1
            63   57  58 1
            64   53  58 1
            65   55  61 1 #Up
            66   61  62 1
            67   56  60 1 #Down
            68   58  59 1 #Down
            69   33  34 2
            70   33  35 2
            71   33  36 1
            72   33  37 1
            73   70  71 2
            74   70  72 2
            75   70  73 1
            76   70  74 1
            77   75  76 2
            78   75  77 2
            79   75  78 1
            80   75  79 1
            81   80  81 2
            82   80  82 2
            83   80  83 1
            84   80  84 1
            85   85  86 2
            86   85  87 2
            87   85  88 1
            88   85  89 1
BRACKET     1    12.8100  -24.7100   12.8100  -11.2000
            1    29.4000  -11.2000   29.4000  -24.7100
            1  2
 ORIGINAL  1    1   2   3   4   5   6  12  13  14  15  16  17  18  21  22  23
            1   24  25  26  27  28  32  31  29  30  20  19  11  10   9   7   8
 REPEAT    1   38  39  40  41  42  43  44  45  46  47  48  49  50  51  52  53
            1   54  55  56  57  58  59  60  61  62  63  64  65  66  67  68  69
            2    31.2200  -20.6500   31.2200  -16.5900
            2    36.7500  -16.5900   36.7500  -20.6500
            2  5
 ORIGINAL  2   33  34  35  36  37
 REPEAT    2   70  71  72  73  74  75  76  77  78  79  80  81  82  83  84  85
            2   86  87  88  89

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