KEGG   DRUG: D02543Help
Entry
D02543                      Drug                                   

Name
Amikacin (USP/INN);
AMK
Formula
C22H43N5O13
Exact mass
585.2857
Mol weight
585.6025
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Semisynthetic aminoglycoside
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX12 Amikacin
      D02543  Amikacin (USP/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB06 Amikacin
      D02543  Amikacin (USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA21 Amikacin
      D02543  Amikacin (USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Amikacin
    D02543  Amikacin (USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Amikacin
      D02543  Amikacin (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
37517-28-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        40
            1   C1y C    16.3913  -20.1724
            2   C1y C    16.3913  -21.5733
            3   C1y C    17.5820  -22.2737
            4   C1y C    18.8429  -21.5733
            5   C1y C    18.8429  -20.1724
            6   O2x O    17.5820  -19.4719
            7   O2a O    20.0336  -19.4719
            8   C1y C    21.2244  -18.7714
            9   C1y C    22.4152  -19.4719
            10  C1x C    23.6760  -18.7714
            11  C1y C    23.6760  -17.3705
            12  C1y C    22.4152  -16.6701
            13  C1y C    21.2244  -17.3705
            14  O2a O    22.4152  -15.2692
            15  C1y C    23.6060  -14.5687
            16  C1b C    15.2005  -19.4719
            17  O1a O    14.0097  -20.1724
            18  O1a O    15.2005  -22.2737
            19  N1a N    17.5820  -23.6746
            20  O1a O    20.0336  -22.2737
            21  N1b N    22.4152  -20.8728
            22  C5a C    23.6060  -21.5733
            23  C1c C    24.8668  -20.8728
            24  C1b C    26.0576  -21.5733
            25  C1b C    27.2483  -20.8728
            26  N1a N    28.5091  -21.5733
            27  O2x O    24.8668  -15.2692
            28  C1y C    26.0576  -14.5687
            29  C1y C    26.0576  -13.1678
            30  C1y C    24.7967  -12.4673
            31  C1y C    23.6060  -13.1678
            32  C1b C    27.3184  -15.2692
            33  N1a N    27.3184  -16.6701
            34  O1a O    27.2483  -12.3973
            35  O1a O    24.7967  -11.0664
            36  O1a O    22.4152  -12.4673
            37  O5a O    23.6060  -22.9742
            38  O1a O    24.8668  -19.4719
            39  N1a N    24.7967  -16.6701
            40  O1a O    20.0336  -16.6701
BOND        42
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     8   7 1 #Down
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   12  14 1 #Down
            16   15  14 1 #Down
            17    1  16 1 #Up
            18   16  17 1
            19    2  18 1 #Down
            20    3  19 1 #Up
            21    4  20 1 #Down
            22    9  21 1 #Up
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   15  27 1
            29   27  28 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   15  31 1
            34   28  32 1 #Up
            35   32  33 1
            36   29  34 1 #Down
            37   30  35 1 #Up
            38   31  36 1 #Down
            39   22  37 2
            40   23  38 1 #Up
            41   11  39 1 #Up
            42   13  40 1 #Up

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