| Entry |
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| Name |
Amikacin (USP/INN);
AMK
|
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| Formula |
C22H43N5O13
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| Exact mass |
585.2857
|
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| Mol weight |
585.6025
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| Structure |
     |
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| Activity |
Antibacterial
|
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| Remark |
|
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| Comment |
Semisynthetic aminoglycoside
|
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| Target |
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO: K01977] |
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| Pathway |
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D06A ANTIBIOTICS FOR TOPICAL USE
D06AX Other antibiotics for topical use
D06AX12 Amikacin
D02543 Amikacin (USP/INN)
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01G AMINOGLYCOSIDE ANTIBACTERIALS
J01GB Other aminoglycosides
J01GB06 Amikacin
D02543 Amikacin (USP/INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AA Antibiotics
S01AA21 Amikacin
D02543 Amikacin (USP/INN)
USP drug classification [BR:br08302]
Antibacterials
Aminoglycosides
Amikacin
D02543 Amikacin (USP/INN)
Antiinfectives [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
16S rRNA of 30S ribosomal subunit inhibitor [KO:K01977]
Aminoglycosides
Amikacin [ATC:D06AX12 J01GB06 S01AA21]
D02543 Amikacin (USP/INN)
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| Other DBs |
CAS: 37517-28-5 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 40
1 C1y C 16.3913 -20.1724
2 C1y C 16.3913 -21.5733
3 C1y C 17.5820 -22.2737
4 C1y C 18.8429 -21.5733
5 C1y C 18.8429 -20.1724
6 O2x O 17.5820 -19.4719
7 O2a O 20.0336 -19.4719
8 C1y C 21.2244 -18.7714
9 C1y C 22.4152 -19.4719
10 C1x C 23.6760 -18.7714
11 C1y C 23.6760 -17.3705
12 C1y C 22.4152 -16.6701
13 C1y C 21.2244 -17.3705
14 O2a O 22.4152 -15.2692
15 C1y C 23.6060 -14.5687
16 C1b C 15.2005 -19.4719
17 O1a O 14.0097 -20.1724
18 O1a O 15.2005 -22.2737
19 N1a N 17.5820 -23.6746
20 O1a O 20.0336 -22.2737
21 N1b N 22.4152 -20.8728
22 C5a C 23.6060 -21.5733
23 C1c C 24.8668 -20.8728
24 C1b C 26.0576 -21.5733
25 C1b C 27.2483 -20.8728
26 N1a N 28.5091 -21.5733
27 O2x O 24.8668 -15.2692
28 C1y C 26.0576 -14.5687
29 C1y C 26.0576 -13.1678
30 C1y C 24.7967 -12.4673
31 C1y C 23.6060 -13.1678
32 C1b C 27.3184 -15.2692
33 N1a N 27.3184 -16.6701
34 O1a O 27.2483 -12.3973
35 O1a O 24.7967 -11.0664
36 O1a O 22.4152 -12.4673
37 O5a O 23.6060 -22.9742
38 O1a O 24.8668 -19.4719
39 N1a N 24.7967 -16.6701
40 O1a O 20.0336 -16.6701
BOND 42
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 5 7 1 #Down
8 8 7 1 #Down
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 8 13 1
15 12 14 1 #Down
16 15 14 1 #Down
17 1 16 1 #Up
18 16 17 1
19 2 18 1 #Down
20 3 19 1 #Up
21 4 20 1 #Down
22 9 21 1 #Up
23 21 22 1
24 22 23 1
25 23 24 1
26 24 25 1
27 25 26 1
28 15 27 1
29 27 28 1
30 28 29 1
31 29 30 1
32 30 31 1
33 15 31 1
34 28 32 1 #Up
35 32 33 1
36 29 34 1 #Down
37 30 35 1 #Up
38 31 36 1 #Down
39 22 37 2
40 23 38 1 #Up
41 11 39 1 #Up
42 13 40 1 #Up
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