KEGG   DRUG: D02558Help
Entry
D02558                      Drug                                   

Name
Rivastigmine tartrate;
Exelon (TN)
Product
  Generic
Formula
C14H22N2O2. C4H6O6
Exact mass
400.1846
Mol weight
400.4235
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of Alzheimer's disease [acetylcholinesterase inhibitor] [DS:H00056]
Remark
ATC code: 
Drug group: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049];
butyrylcholinesterase (BChE) inhibitor [HSA:590] [KO:K01050]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA03 Rivastigmine
      D02558  Rivastigmine tartrate
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Rivastigmine
    D02558  Rivastigmine tartrate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Rivastigmine
     D02558  Rivastigmine tartrate
   butyrylcholinesterase (BChE)
    Rivastigmine
     D02558  Rivastigmine tartrate
BRITE hierarchy
Other DBs
CAS: 
129101-54-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    26.6428  -17.5078
            2   C8x C    27.8616  -16.8021
            3   C8x C    26.6486  -18.9132
            4   O7a O    25.4297  -16.8080
            5   C8y C    29.0745  -17.5078
            6   C8x C    27.8616  -19.6129
            7   C7a C    24.2168  -17.5135
            8   C8x C    29.0745  -18.9074
            9   N1c N    22.9980  -16.8137
            10  O6a O    24.2168  -18.9191
            11  C1a C    21.7908  -17.5195
            12  C1c C    30.2840  -16.8122
            13  N1c N    31.4912  -17.5118
            14  C1a C    30.2864  -15.4169
            15  C1a C    31.4888  -18.9071
            16  C1a C    32.7005  -16.8163
            17  C1b C    23.0621  -15.4005
            18  C1a C    24.2797  -14.7690
            19  O6a O    36.3299  -17.4300
            20  C6a C    37.5423  -16.7300
            21  C1c C    38.7548  -17.4300
            22  C1c C    39.9672  -16.7300
            23  C6a C    41.1795  -17.4300
            24  O6a O    42.3920  -16.7300
            25  O6a O    37.5423  -15.3301
            26  O6a O    41.1795  -18.8299
            27  O1a O    38.7799  -18.8300
            28  O1a O    39.9699  -15.3299
BOND        27
            1     5   8 2
            2     7   9 1
            3     7  10 2
            4     9  11 1
            5     6   8 1
            6     5  12 1
            7     1   2 2
            8    12  13 1
            9     1   3 1
            10   12  14 1 #Down
            11    1   4 1
            12   13  15 1
            13    2   5 1
            14   13  16 1
            15    3   6 2
            16    4   7 1
            17    9  17 1
            18   17  18 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   20  25 2
            25   23  26 2
            26   21  27 1 #Up
            27   22  28 1 #Up

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