KEGG   DRUG: Rivastigmine tartrateHelp
Entry
D02558                      Drug                                   

Name
Rivastigmine tartrate;
Exelon (TN)
Product
  Generic
Formula
C14H22N2O2. C4H6O6
Exact mass
400.1846
Mol weight
400.4235
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
  DG01594  Butyrylcholinesterase inhibitor
Unclassified
 DG01968  Agents for Alzheimer-type dementia
Remark
ATC code: 
Chemical group: 
Activity
Nootropic, Acetylcholinesterase inhibitor
Comment
Physostigmine derivative
Treatment of Alzheimer's disease
Target
ACHE [HSA:43] [KO:K01049];
BCHE [HSA:590] [KO:K01050]
  Pathway
Glycerophospholipid metabolism
Cholinergic synapse
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA03 Rivastigmine
      D02558  Rivastigmine tartrate
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Rivastigmine
    D02558  Rivastigmine tartrate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Rivastigmine
     D02558  Rivastigmine tartrate
   butyrylcholinesterase (BChE)
    Rivastigmine
     D02558  Rivastigmine tartrate
Neurological agents [br08367.html]
 Anti-Alzheimer agents
  D02558
BRITE hierarchy
Other DBs
CAS: 
129101-54-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    26.6428  -17.5078
            2   C8x C    27.8616  -16.8021
            3   C8x C    26.6486  -18.9132
            4   O7a O    25.4297  -16.8080
            5   C8y C    29.0745  -17.5078
            6   C8x C    27.8616  -19.6129
            7   C7a C    24.2168  -17.5135
            8   C8x C    29.0745  -18.9074
            9   N1c N    22.9980  -16.8137
            10  O6a O    24.2168  -18.9191
            11  C1a C    21.7908  -17.5195
            12  C1c C    30.2840  -16.8122
            13  N1c N    31.4912  -17.5118
            14  C1a C    30.2864  -15.4169
            15  C1a C    31.4888  -18.9071
            16  C1a C    32.7005  -16.8163
            17  C1b C    23.0621  -15.4005
            18  C1a C    24.2797  -14.7690
            19  O6a O    36.3299  -17.4300
            20  C6a C    37.5423  -16.7300
            21  C1c C    38.7548  -17.4300
            22  C1c C    39.9672  -16.7300
            23  C6a C    41.1795  -17.4300
            24  O6a O    42.3920  -16.7300
            25  O6a O    37.5423  -15.3301
            26  O6a O    41.1795  -18.8299
            27  O1a O    38.7799  -18.8300
            28  O1a O    39.9699  -15.3299
BOND        27
            1     5   8 2
            2     7   9 1
            3     7  10 2
            4     9  11 1
            5     6   8 1
            6     5  12 1
            7     1   2 2
            8    12  13 1
            9     1   3 1
            10   12  14 1 #Down
            11    1   4 1
            12   13  15 1
            13    2   5 1
            14   13  16 1
            15    3   6 2
            16    4   7 1
            17    9  17 1
            18   17  18 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   20  25 2
            25   23  26 2
            26   21  27 1 #Up
            27   22  28 1 #Up

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