KEGG   DRUG: D02593Help
Entry
D02593                      Drug                                   
Name
Pantoprazole Sodium Hydrate (JAN);
Pantoprazole sodium (USAN);
Protonix (TN)
Product
  Generic
PANTOPRAZOLE (Cardinal Health), PANTOPRAZOLE (Dr.Reddy's Laboratories Limited), PANTOPRAZOLE (Legacy Pharmaceutical Packaging), PANTOPRAZOLE (Major Pharmaceuticals), PANTOPRAZOLE SODIUM (Actavis), PANTOPRAZOLE SODIUM (Akorn), PANTOPRAZOLE SODIUM (American Health Packaging), PANTOPRAZOLE SODIUM (American Health Packaging), PANTOPRAZOLE SODIUM (American Health Packaging), PANTOPRAZOLE SODIUM (Aphena Pharma Solutions - Tennessee), PANTOPRAZOLE SODIUM (Aurobindo Pharma Limited), PANTOPRAZOLE SODIUM (AvPAK), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Bryant Ranch Prepack), PANTOPRAZOLE SODIUM (Cardinal Health), PANTOPRAZOLE SODIUM (Cardinal Health), PANTOPRAZOLE SODIUM (Jubilant Cadista Pharmaceuticals), PANTOPRAZOLE SODIUM (Kremers Urban Pharmaceuticals), PANTOPRAZOLE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), PANTOPRAZOLE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), PANTOPRAZOLE SODIUM (Legacy Pharmaceutical Packaging), PANTOPRAZOLE SODIUM (Macleods Pharmaceuticals Limited), PANTOPRAZOLE SODIUM (McKesson Packaging Services a business unit of McKesson Corporation), PANTOPRAZOLE SODIUM (Mylan Institutional), PANTOPRAZOLE SODIUM (Mylan Pharmaceuticals), PANTOPRAZOLE SODIUM (NCS HealthCare of KY), PANTOPRAZOLE SODIUM (Physicians Total Care), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (REMEDYREPACK), PANTOPRAZOLE SODIUM (Rebel Distributors Corp), PANTOPRAZOLE SODIUM (Rebel Distributors Corp), PANTOPRAZOLE SODIUM (Sun Pharma Global FZE), PANTOPRAZOLE SODIUM (Teva Pharmaceuticals USA), PANTOPRAZOLE SODIUM (Torrent Pharmaceuticals Limited), PANTOPRAZOLE SODIUM (Unit Dose Services), PANTOPRAZOLE SODIUM (Unit Dose Services), PANTOPRAZOLE SODIUM (WOCKHARDT LIMITED), PANTOPRAZOLE SODIUM (WOCKHARDT USA LLC.)
Formula
(C16H14F2N3O4S. Na)2. 3H2O
Exact mass
864.1458
Mol weight
864.7491
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of various acid-related gastrointestinal diseases, including acute erosive esophagitis healing and maintenance, treatment of hypersecretory conditions, Zollinger-Ellison Syndrome (ZES), and eradication of Helicobacter pylori infection
Remark
ATC code: 
Comment
proton pump inhibitor
Target
H+/K+ exchanging, alpha polypeptide inhibitor [HSA:495] [KO:K01542];
H+/K+ exchanging, beta polypeptide inhibitor [HSA:496] [KO:K01543]
  Pathway
hsa00190  Oxidative phosphorylation
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Structure map
Antiulcer drugs
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC02 Pantoprazole
      D02593  Pantoprazole Sodium Hydrate (JAN); Pantoprazole sodium (USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Pantoprazole
    D02593  Pantoprazole Sodium Hydrate (JAN); Pantoprazole sodium (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide [HSA:495 496] [KO:K01542 K01543]
    Pantoprazole [ATC:A02BC02]
     D02593  Pantoprazole Sodium Hydrate (JAN); Pantoprazole sodium (USAN)
BRITE hierarchy
Other DBs
CAS: 
164579-32-2
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        57
            1   O0  O    31.5571  -29.4634
            2   Z   Na   18.5500  -23.1700 #+
            3   C8x C    13.5100  -24.5700
            4   C8y C    13.5100  -25.9700
            5   C8x C    14.7000  -26.6700
            6   C8y C    15.8900  -25.9700
            7   C8y C    15.8900  -24.5700
            8   C8x C    14.7000  -23.8700
            9   N5x N    17.2900  -26.3900
            10  C8y C    18.0600  -25.2700
            11  N4x N    17.2900  -24.1500 #-
            12  S4a S    19.4600  -25.2700
            13  C1b C    20.1600  -26.5300
            14  O3c O    20.1600  -24.0800
            15  O2a O    12.2500  -26.6700
            16  C1c C    11.0600  -25.9700
            17  X   F     9.8700  -26.6700
            18  X   F    11.0600  -24.5700
            19  C8y C    21.5600  -26.5300
            20  C8y C    22.2600  -27.7200
            21  C8y C    23.6600  -27.7200
            22  C8x C    24.3600  -26.4600
            23  C8x C    23.6600  -25.2700
            24  N5x N    22.2600  -25.2700
            25  O2a O    21.5600  -28.9100
            26  C1a C    20.1600  -28.9100
            27  O2a O    24.3600  -28.9100
            28  C1a C    25.7600  -28.9100
            29  O0  O    31.5571  -29.4634
            30  O0  O    31.5571  -29.4634
            31  Z   Na   18.5500  -23.1700 #+
            32  C8x C    13.5100  -24.5700
            33  C8y C    13.5100  -25.9700
            34  C8x C    14.7000  -26.6700
            35  C8y C    15.8900  -25.9700
            36  C8y C    15.8900  -24.5700
            37  C8x C    14.7000  -23.8700
            38  N4x N    17.2900  -24.1500 #-
            39  C8y C    18.0600  -25.2700
            40  N5x N    17.2900  -26.3900
            41  S4a S    19.4600  -25.2700
            42  C1b C    20.1600  -26.5300
            43  C8y C    21.5600  -26.5300
            44  C8y C    22.2600  -27.7200
            45  C8y C    23.6600  -27.7200
            46  C8x C    24.3600  -26.4600
            47  C8x C    23.6600  -25.2700
            48  N5x N    22.2600  -25.2700
            49  O2a O    24.3600  -28.9100
            50  C1a C    25.7600  -28.9100
            51  O2a O    21.5600  -28.9100
            52  C1a C    20.1600  -28.9100
            53  O3c O    20.1600  -24.0800
            54  O2a O    12.2500  -26.6700
            55  C1c C    11.0600  -25.9700
            56  X   F     9.8700  -26.6700
            57  X   F    11.0600  -24.5700
BOND        56
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     6   9 1
            8     9  10 2
            9    10  11 1
            10    7  11 1
            11   10  12 1
            12   12  13 1
            13   12  14 2
            14    4  15 1
            15   15  16 1
            16   16  17 1
            17   16  18 1
            18   13  19 1
            19   19  20 2
            20   20  21 1
            21   21  22 2
            22   22  23 1
            23   23  24 2
            24   19  24 1
            25   20  25 1
            26   25  26 1
            27   21  27 1
            28   27  28 1
            29   32  33 2
            30   33  34 1
            31   34  35 2
            32   35  36 1
            33   36  37 2
            34   32  37 1
            35   35  40 1
            36   40  39 2
            37   39  38 1
            38   36  38 1
            39   39  41 1
            40   41  42 1
            41   41  53 2
            42   33  54 1
            43   54  55 1
            44   55  56 1
            45   55  57 1
            46   42  43 1
            47   43  44 2
            48   44  45 1
            49   45  46 2
            50   46  47 1
            51   47  48 2
            52   43  48 1
            53   44  51 1
            54   51  52 1
            55   45  49 1
            56   49  50 1
BRACKET     1    29.4000  -29.9600   29.4000  -28.7000
            1    32.2000  -28.7000   32.2000  -29.9600
            1  3
 ORIGINAL  1    1
 REPEAT    1   29  30
            2     9.1700  -29.9600    9.1700  -22.2600
            2    27.5800  -22.2600   27.5800  -29.9600
            2  2
 ORIGINAL  2    2   3   4   5   6   7   8  11  10   9  12  13  19  20  21  22
            2   23  24  27  28  25  26  14  15  16  17  18
 REPEAT    2   31  32  33  34  35  36  37  38  39  40  41  42  43  44  45  46
            2   47  48  49  50  51  52  53  54  55  56  57

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