KEGG   DRUG: TocilizumabHelp
Entry
D02596                      Drug                                   

Name
Tocilizumab (USAN/INN);
Tocilizumab (genetical recombination) (JAN);
Actemra (TN)
Product
Formula
C6428H9976N1720O2018S42
Exact mass
144895.9145
Mol weight
144985.0322
Remark
Therapeutic category: 
ATC code: 
Activity
Anti-inflammatory, Antirheumatic, Immunosuppressant
  Disease
Rheumatoid arthritis [DS:H00630]
Polyarticular juvenile idiopathic arthritis [DS:H01672]
Systemic juvenile idiopathic arthritis [DS:H01672]
Comment
Monoclonal antibody
Target
IL6R (CD126) [HSA:3570] [KO:K05055]
  Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Interaction
Drug interaction
Structure map
Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC07 Tocilizumab
      D02596  Tocilizumab (USAN/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immunomodulators
   Tocilizumab
    D02596  Tocilizumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D02596  Tocilizumab (USAN/INN); Tocilizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   interleukin 6 receptor
    Tocilizumab
     D02596  Tocilizumab (USAN/INN)
Antirheumatic and antigout drugs [br08366.html]
 Antirheumatic drugs
  D02596
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02596
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D02596
BRITE hierarchy
Other DBs
CAS: 
375823-41-9
PubChem: 
NIKKAJI: 

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