KEGG   DRUG: TocilizumabHelp
Entry
D02596                      Drug                                   

Name
Tocilizumab (USAN/INN);
Tocilizumab (genetical recombination) (JAN);
Actemra (TN)
Product
Formula
C6428H9976N1720O2018S42
Exact mass
144895.9145
Mol weight
144985.0322
Remark
Therapeutic category: 
ATC code: 
Comment
humanized anti-human IL-6 receptor monoclonal antybody
Treatmet of Castelman's disease, Treatment of multiple myeloma, Treatment of systemic lupus erythematosus, Treatment of Crohs's disease, Treatment of rheumatoid arthritis, Treatment of systemic juvenile idiopathic arthritis
Target
interleukin-6 (IL-6) receptor [HSA:3570] [KO:K05055]
  Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Interaction
Drug interaction
Structure map
Antirheumatics - DMARDs and biological agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC07 Tocilizumab
      D02596  Tocilizumab (USAN/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immunomodulators
   Tocilizumab
    D02596  Tocilizumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D02596  Tocilizumab (USAN/INN); Tocilizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   interleukin 6 receptor
    Tocilizumab
     D02596  Tocilizumab (USAN/INN)
Antirheumatic and antigout drugs [br08366.html]
 Antirheumatic drugs
  D02596
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02596
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D02596
BRITE hierarchy
Other DBs
CAS: 
375823-41-9
PubChem: 
NIKKAJI: 

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