KEGG   DRUG: D02599Help
Entry
D02599                      Drug                                   

Name
Orphenadrine hydrochloride;
Disipal (TN)
Formula
C18H23NO. HCl
Exact mass
305.1546
Mol weight
305.8423
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic;
Relaxant [skeletal muscle]
Remark
ATC code: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AB Ethers chemically close to antihistamines
     N04AB02 Orphenadrine (chloride)
      D02599  Orphenadrine hydrochloride
USP drug classification [BR:br08302]
 Skeletal Muscle Relaxants
  Orphenadrine
   D02599  Orphenadrine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Orphenadrine (chloride)
      D02599  Orphenadrine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
341-69-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   X   Cl   41.4554  -19.1198
            2   C1a C    30.9280  -20.7988
            3   N1c N    32.1419  -20.0980
            4   C1b C    33.3557  -20.7988
            5   C1b C    34.5696  -20.0980
            6   O2a O    35.7834  -20.7988
            7   C1c C    36.9972  -20.0980
            8   C8y C    38.2111  -20.7988
            9   C8y C    36.9972  -18.6965
            10  C8x C    38.1983  -18.0030
            11  C8x C    38.1982  -16.6013
            12  C8x C    36.9843  -15.9006
            13  C8x C    35.7833  -16.5941
            14  C8y C    35.7834  -17.9958
            15  C8x C    38.2111  -22.2005
            16  C8x C    39.4250  -22.9013
            17  C8x C    40.6389  -22.2005
            18  C8x C    40.6389  -20.7988
            19  C8x C    39.4250  -20.0980
            20  C1a C    34.5737  -18.6943
            21  C1a C    32.1419  -18.6964
BOND        21
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     7   9 1
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14    8  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19    8  19 2
            20   14  20 1
            21    3  21 1

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