KEGG   DRUG: D02624Help
Entry
D02624                      Drug                                   

Name
Eszopiclone (JAN/USAN/INN);
Estorra (TN);
Lunesta (TN)
Product
  Generic
ESZOPICLONE (A-S Medication Solutions LLC), ESZOPICLONE (A-S Medication Solutions LLC), ESZOPICLONE (A-S Medication Solutions LLC), ESZOPICLONE (A-S Medication Solutions LLC), ESZOPICLONE (AvKARE), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (Bryant Ranch Prepack), ESZOPICLONE (DIRECT RX), ESZOPICLONE (Direct Rx), ESZOPICLONE (Dr. Reddy's Laboratories Limited), ESZOPICLONE (Glenmark Generics Inc. USA), ESZOPICLONE (Lupin Pharmaceuticals), ESZOPICLONE (Macleods Pharmaceuticals Limited), ESZOPICLONE (Mylan Institutional), ESZOPICLONE (Mylan Pharmaceuticals), ESZOPICLONE (OrchidPharma), ESZOPICLONE (Preferred Pharmaceuticals), ESZOPICLONE (Preferred Pharmaceuticals), ESZOPICLONE (Preferred Pharmaceuticals), ESZOPICLONE (Preferred Pharmaceuticals), ESZOPICLONE (Preferred Pharmaceuticals), ESZOPICLONE (Proficient Rx LP), ESZOPICLONE (Roxane Laboratories), ESZOPICLONE (Sun Pharma Global FZE), ESZOPICLONE (Teva Pharmaceuticals USA), ESZOPICLONE (Unit Dose Services), ESZOPICLONE (Unit Dose Services)
Formula
C17H17ClN6O3
Exact mass
388.1051
Mol weight
388.8083
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of insomnia
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
See Zopiclone [DR:D01372]
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Interaction
Drug interaction
Structure map
Hypnotics
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF04 Eszopiclone
      D02624  Eszopiclone (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Eszopiclone
    D02624  Eszopiclone (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1129  Others
     D02624  Eszopiclone (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Eszopiclone
      D02624  Eszopiclone (JAN/USAN/INN)
Neuropsychiatric agents [br08363.html]
 Hypnotics
  D02624
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02624
BRITE hierarchy
Other DBs
CAS: 
138729-47-2
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8x C    13.5800  -12.3200
            2   C8x C    13.5800  -13.7200
            3   N5x N    14.7700  -14.4200
            4   C8y C    16.0300  -13.7200
            5   C8y C    16.0300  -12.3200
            6   N5x N    14.7700  -11.6200
            7   C1y C    17.3600  -14.1400
            8   N1y N    18.2000  -13.0200
            9   C5x C    17.3600  -11.9000
            10  C8y C    19.5300  -13.0200
            11  N5x N    20.2300  -11.8300
            12  C8x C    21.6300  -11.8300
            13  C8y C    22.3300  -13.0200
            14  C8x C    21.6300  -14.2100
            15  C8x C    20.2300  -14.2100
            16  O5x O    17.7800  -10.5700
            17  X   Cl   23.7300  -13.0200
            18  O7a O    17.3600  -15.5400
            19  C7a C    18.5500  -16.2400
            20  N1y N    18.5500  -17.6400
            21  O6a O    19.8100  -15.5400
            22  C1x C    17.3600  -18.3400
            23  C1x C    17.3600  -19.7400
            24  N1y N    18.5500  -20.4400
            25  C1x C    19.8100  -19.7400
            26  C1x C    19.8100  -18.3400
            27  C1a C    18.5500  -21.8400
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   10  15 1
            18    9  16 2
            19   13  17 1
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23    7  18 1 #Up
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   20  26 1
            30   24  27 1

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