KEGG   DRUG: D02691Help
Entry
D02691                      Drug                                   

Name
Somatropin (genetical recombination) (JAN);
Human growth hormone (JAN);
Somatropin (USP/INN);
Asellacrin (TN);
Nutropin (TN);
Omnitrope (TN)
Product
Formula
C990H1528N262O300S7
Exact mass
22111.0409
Mol weight
22124.7557
Sequence
FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV
QCRSVEGSCG F (Disulfide bridge: 53-165, 182-189)
  Type
Peptide
Activity
Hormone [growth]
Remark
Therapeutic category: 
ATC code: 
Comment
human growth hormone derivative
Target
growth hormone receptor agonist [HSA:2690] [KO:K05080]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04080  Neuroactive ligand-receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Interaction
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   241  Pituitary hormone preparations
    2412  Anterior pituitary hormones
     D02691  Somatropin (genetical recombination) (JAN); Human growth hormone (JAN); Somatropin (USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AC Somatropin and somatropin agonists
     H01AC01 Somatropin
      D02691  Somatropin (genetical recombination) (JAN); Human growth hormone (JAN); Somatropin (USP/INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Somatropin
    D02691  Somatropin (genetical recombination) (JAN); Human growth hormone (JAN); Somatropin (USP/INN)
 Hormonal Agents, Stimulant/Replacement/Modifying (Pituitary)
  Somatropin, recombinant
   D02691  Somatropin (genetical recombination) (JAN); Human growth hormone (JAN); Somatropin (USP/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   growth hormone receptor [HSA:2690] [KO:K05080]
    Somatropin [ATC:H01AC01]
     D02691  Somatropin (genetical recombination) (JAN); Somatropin (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
12629-01-5
PubChem: 
DrugBank: 
NIKKAJI: 

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