KEGG   DRUG: Alprostadil alfadexHelp
Entry
D02705                      Drug                                   

Name
Alprostadil alfadex (JP17);
Tandetron (TN)
Formula
(C36H60O30)x. C20H34O5
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01611  Prostaglandin E1 derivative
Other
 DG01961  Prostaglandin derivative
  DG01611  Prostaglandin E1 derivative
Unclassified
 DG02573  Prostanoid derivative
  DG01961  Prostaglandin derivative
   DG01611  Prostaglandin E1 derivative
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Anti-ulcerative (skin), Vasodilator, Prostaglandin E1 receptor agonist
Comment
Prostaglandin derivative
Target
PTGER1 [HSA:5731] [KO:K04258]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
Prostaglandins
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01E OTHER CARDIAC PREPARATIONS
    C01EA Prostaglandins
     C01EA01 Alprostadil
      D02705  Alprostadil alfadex (JP17)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BE Drugs used in erectile dysfunction
     G04BE01 Alprostadil
      D02705  Alprostadil alfadex (JP17)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Prostaglandins)
  Alprostadil
   D02705  Alprostadil alfadex (JP17)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D02705  Alprostadil alfadex (JP17)
  26  Epidermides
   269  Miscellaneous
    2699  Others
     D02705  Alprostadil alfadex (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    Prostaglandin E2 receptor EP1 subtype
     Alprostadil
      D02705  Alprostadil alfadex (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02705  Alprostadil alfadex
Dermatological agents [br08370.html]
 Non-steroidal topical agent
  D02705
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        91
            1   C1y C     7.9030  -14.4151
            2   C1y C     7.8970  -15.8249
            3   C5x C     6.5630  -13.9840
            4   C1b C     9.1147  -13.7101
            5   C1y C     6.5804  -16.2560
            6   C2b C     9.1147  -16.5183
            7   C1x C     5.7415  -15.1257
            8   O5x O     6.1261  -12.6556
            9   C1b C    10.3266  -14.4151
            10  O1a O     6.1609  -17.5903
            11  C2b C    10.3266  -15.8249
            12  C1b C    11.5443  -13.7101
            13  C1c C    11.5443  -16.5183
            14  C1b C    12.7501  -14.4151
            15  C1b C    12.7560  -15.8249
            16  O1a O    11.5443  -17.9223
            17  C1b C    13.9677  -13.7101
            18  C1b C    13.9677  -16.5183
            19  C1b C    15.1854  -14.4151
            20  C1b C    15.1854  -15.8249
            21  C6a C    16.3973  -13.7101
            22  C1b C    16.3973  -16.5183
            23  O6a O    17.6090  -14.4209
            24  O6a O    16.3506  -12.3468
            25  C1a C    17.6150  -15.8249
            26  C1y C    34.2300  -11.4100
            27  C1y C    32.9000  -11.4100
            28  O2x O    32.2000  -12.6000
            29  C1y C    32.9000  -13.7200
            30  C1y C    34.2300  -13.7200
            31  C1y C    34.9300  -12.5300
            32  O2x O    32.9000  -16.4500
            33  C1y C    34.2300  -16.4500
            34  O2a O    34.9300  -15.0500
            35  C1y C    32.2000  -17.6400
            36  C1y C    32.9000  -18.8300
            37  C1y C    34.2300  -18.8300
            38  C1y C    34.9300  -17.6400
            39  O1a O    36.2600  -12.5300
            40  O1a O    34.9300  -20.0200
            41  O1a O    34.9300  -10.2200
            42  O1a O    36.2600  -17.6400
            43  O2a O    32.2000  -10.2200
            44  C1y C    30.3800  -10.2200
            45  C1y C    29.6100  -11.4100
            46  O2x O    29.6800  -18.8300
            47  C1y C    30.3800  -20.0200
            48  O2a O    32.2700  -20.0200
            49  C1y C    29.6100   -9.1000
            50  C1y C    28.2800   -9.0300
            51  C1y C    27.5800  -10.2200
            52  O2x O    28.2800  -11.4100
            53  C1y C    28.3500  -18.8300
            54  C1y C    27.6500  -20.0200
            55  C1y C    28.3500  -21.2100
            56  C1y C    29.6800  -21.2100
            57  O1a O    30.3800  -22.4000
            58  O1a O    27.5800   -7.8400
            59  O1a O    30.3100   -7.8400
            60  O2a O    25.7600  -10.2200
            61  O1a O    27.6500  -22.4000
            62  O2a O    25.8300  -20.0200
            63  O2x O    25.8300  -17.7100
            64  C1y C    25.2000  -18.9700
            65  C1y C    25.2000  -11.4100
            66  C1y C    25.8300  -12.6000
            67  C1y C    23.8000  -11.4100
            68  C1y C    23.1700  -12.6000
            69  C1y C    23.8000  -13.7900
            70  O2x O    25.2000  -13.7900
            71  C1y C    25.2000  -16.5200
            72  C1y C    23.8000  -16.5200
            73  C1y C    23.1700  -17.7100
            74  C1y C    23.8000  -18.9000
            75  O1a O    23.1700  -10.2200
            76  O2a O    23.1000  -15.1900
            77  O1a O    21.7700  -17.7100
            78  O1a O    21.7700  -12.6000
            79  O1a O    23.1700  -20.0900
            80  C1b C    27.5800  -17.6400
            81  C1b C    25.9000  -15.3300
            82  C1b C    27.1600  -12.6000
            83  C1b C    30.3100  -12.6000
            84  C1b C    32.2000  -14.9800
            85  C1b C    30.8000  -17.6400
            86  O1a O    28.3500  -16.5900
            87  O1a O    27.3000  -15.3300
            88  O1a O    27.8600  -13.7900
            89  O1a O    29.9600  -14.0000
            90  O1a O    30.8700  -15.0500
            91  O1a O    30.1000  -16.3800
BOND        97
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1 #Down
            10    6  11 2
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1 #Down
            16   14  17 1
            17   15  18 1
            18   17  19 1
            19   18  20 1
            20   19  21 1
            21   20  22 1
            22   21  23 1
            23   21  24 2
            24   22  25 1
            25    5   7 1
            26   26  27 1
            27   27  28 1
            28   28  29 1
            29   29  30 1
            30   30  31 1
            31   26  31 1
            32   32  33 1
            33   33  34 1 #Down
            34   30  34 1 #Down
            35   32  35 1
            36   35  36 1
            37   36  37 1
            38   37  38 1
            39   33  38 1
            40   31  39 1 #Up
            41   37  40 1 #Up
            42   26  41 1 #Down
            43   38  42 1 #Down
            44   27  43 1 #Down
            45   44  43 1 #Down
            46   44  45 1
            47   47  46 1
            48   47  48 1 #Down
            49   36  48 1 #Down
            50   44  49 1
            51   49  50 1
            52   50  51 1
            53   51  52 1
            54   45  52 1
            55   46  53 1
            56   53  54 1
            57   54  55 1
            58   55  56 1
            59   47  56 1
            60   56  57 1 #Down
            61   50  58 1 #Down
            62   49  59 1 #Up
            63   51  60 1 #Down
            64   55  61 1 #Up
            65   54  62 1 #Down
            66   63  64 1
            67   64  62 1 #Down
            68   65  60 1 #Down
            69   65  66 1
            70   65  67 1
            71   67  68 1
            72   68  69 1
            73   69  70 1
            74   66  70 1
            75   63  71 1
            76   71  72 1
            77   72  73 1
            78   73  74 1
            79   64  74 1
            80   67  75 1 #Up
            81   69  76 1 #Down
            82   72  76 1 #Down
            83   73  77 1 #Up
            84   68  78 1 #Down
            85   74  79 1 #Down
            86   53  80 1 #Up
            87   71  81 1 #Up
            88   66  82 1 #Up
            89   45  83 1 #Up
            90   29  84 1 #Up
            91   35  85 1 #Up
            92   80  86 1
            93   81  87 1
            94   82  88 1
            95   83  89 1
            96   84  90 1
            97   85  91 1
BRACKET     1    19.9500  -23.1000   19.9500   -6.9300
            1    37.9400   -6.9300   37.9400  -23.1000
            1  x
 ORIGINAL  1   26  27  28  29  30  31  32  33  34  35  36  37  38  39  40  41
            1   42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57
            1   58  59  60  61  62  63  64  65  66  67  68  69  70  71  72  73
            1   74  75  76  77  78  79  80  81  82  83  84  85  86  87  88  89
            1   90  91
 REPEAT    1

» Japanese version   » Back

DBGET integrated database retrieval system