KEGG   DRUG: PregabalinHelp
Entry
D02716                      Drug                                   

Name
Pregabalin (JAN/USAN/INN);
Lyrica (TN)
Product
LYRICA (Direct RX), LYRICA (DirectRX), LYRICA (Aphena Pharma Solutions - Tennessee), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Cardinal Health), PREGABALIN (DIRECT RX), LYRICA (DIRECT RX), LYRICA (Dispensing Solutions), LYRICA (Dispensing Solutions), LYRICA (H.J. Harkins Company), LYRICA (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LYRICA (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LYRICA (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LYRICA (Lake Erie Medical & Surgical Supply), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA CR (Parke-Davis Div of Pfizer), LYRICA (Parke-Davis Div of Pfizer), LYRICA (Physicians Total Care), LYRICA (REMEDYREPACK), LYRICA (REMEDYREPACK), LYRICA (REMEDYREPACK), LYRICA (REMEDYREPACK), LYRICA (REMEDYREPACK), LYRICA (REMEDYREPACK), LYRICA (REMEDYREPACK), LYRICA (Rebel Distributors Corp), LYRICA (Rebel Distributors Corp), LYRICA (U.S. Pharmaceuticals), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services)
  Generic
Formula
C8H17NO2
Exact mass
159.1259
Mol weight
159.2261
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG02037  GABA mimetic antiepileptics
Other
 DG01575  Calcium channel blocker
  DG01574  Calcium channel alpha-2 delta blocker
Remark
Therapeutic category: 1190
ATC code: N03AX16
Product: D02716<JP/US>
Efficacy
Anticonvulsant, Pain relief
  Disease
Diabetic peripheral neuropathy [DS:H01459]
Postherpetic neuralgia [DS:H01624]
Fibromyalgia [DS:H01636]
Comment
GABA [CPD:C00334] analog
Target
  Pathway
hsa04010  MAPK signaling pathway
Interaction
Drug interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX16 Pregabalin
      D02716  Pregabalin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Calcium Channel Modifying Agents
   Pregabalin
    D02716  Pregabalin (JAN/USAN/INN)
 Central Nervous System Agents
  Fibromyalgia Agents
   Pregabalin
    D02716  Pregabalin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02716  Pregabalin (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA2D
     D02716  Pregabalin (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D02716
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02716
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02716
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02716
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02716
BRITE hierarchy
Other DBs
CAS: 148553-50-8
PubChem: 17396883
ChEBI: 64356
ChEMBL: CHEMBL1059
DrugBank: DB00230
LigandBox: D02716
NIKKAJI: J702.547E
KCF data Show

ATOM        11
            1   C1c C    20.4400  -16.3100
            2   C1b C    21.6300  -17.0800
            3   C6a C    22.8900  -16.3100
            4   O6a O    24.0100  -17.0800
            5   O6a O    22.8900  -14.9800
            6   C1b C    19.2500  -17.0100
            7   N1a N    18.0347  -16.3149
            8   C1b C    20.4698  -14.9103
            9   C1c C    19.2508  -14.1713
            10  C1a C    18.0363  -14.8379
            11  C1a C    19.2816  -12.7404
BOND        10
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 2
            5     1   6 1 #Up
            6     6   7 1
            7     1   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 1

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