KEGG   DRUG: D02716Help
Entry
D02716                      Drug                                   

Name
Pregabalin (JAN/USAN/INN);
Lyrica (TN)
Product
LYRICA (A-S Medication Solutions LLC), LYRICA (A-S Medication Solutions LLC), LYRICA (Aphena Pharma Solutions - Tennessee), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Cardinal Health), LYRICA (Dispensing Solutions), LYRICA (Dispensing Solutions), LYRICA (H.J. Harkins Company), LYRICA (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LYRICA (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LYRICA (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LYRICA (Lake Erie Medical & Surgical Supply), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (Parke-Davis Div of Pfizer), LYRICA (Physicians Total Care), LYRICA (REMEDYREPACK), LYRICA (Rebel Distributors Corp), LYRICA (Rebel Distributors Corp), LYRICA (STAT Rx USA LLC), LYRICA (STAT Rx USA LLC), LYRICA (St Marys Medical Park Pharmacy), LYRICA (U.S. Pharmaceuticals), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services), LYRICA (Unit Dose Services)
  Generic
Formula
C8H17NO2
Exact mass
159.1259
Mol weight
159.2261
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant
Remark
Therapeutic category: 
ATC code: 
Comment
GABA [CPD:C00334] analog
Pregabalin binds to the alpha-2/delta subunit of voltage-dependent calcium channel.
Target
calcium channel, CACN alpha-2 delta blocker  [HSA:781 9254 55799 93589] [KO:K04858 K04859 K04860 K04861]
  Pathway
hsa04010  MAPK signaling pathway  
 
Interaction
Drug interaction
Structure map
Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX16 Pregabalin
      D02716  Pregabalin (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Calcium Channel Modifying Agents
   Pregabalin
    D02716  Pregabalin (JAN/USAN/INN)
 Central Nervous System Agents
  Fibromyalgia Agents
   Pregabalin
    D02716  Pregabalin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02716  Pregabalin (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    voltage-dependent calcium channel
     Pregabalin
      D02716  Pregabalin (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
148553-50-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        11
            1   C1c C    22.4413  -19.6552
            2   C1b C    22.4472  -18.2475
            3   C1b C    21.2605  -20.3882
            4   C6a C    21.1381  -17.6077
            5   N1a N    20.0330  -19.7308
            6   O6a O    21.1442  -16.2174
            7   O6a O    19.9690  -18.3581
            8   C1b C    23.6879  -20.3119
            9   C1c C    24.8890  -19.5551
            10  C1a C    26.1125  -20.1995
            11  C1a C    24.9038  -18.1345
BOND        10
            1     1   2 1
            2     1   3 1 #Down
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 2
            7     1   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 1

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