KEGG   DRUG: D02721Help
Entry
D02721                      Drug                                   

Name
Iloprost (USAN/INN);
Ventavis (TN)
Product
Formula
C22H32O4
Exact mass
360.2301
Mol weight
360.4871
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of pulmonary hypertension (prostacyclin analogue)
Remark
ATC code: 
Target
prostaglandin I2 receptor agonist [HSA:5739] [KO:K04263]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Structure map
Eicosanoids
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC11 Iloprost
      D02721  Iloprost (USAN/INN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Iloprost
    D02721  Iloprost (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    prostaglandin I2 receptor [HSA:5739] [KO:K04263]
     Iloprost [ATC:B01AC11]
      D02721  Iloprost (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
78919-13-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C1x C     8.0500  -25.0600
            2   C1y C     8.8900  -26.1800
            3   C1y C    10.2200  -25.6900
            4   C1y C    10.2200  -24.2900
            5   C1y C     8.8900  -23.8700
            6   O1a O     8.4000  -27.5100
            7   C1x C    11.0600  -23.1700
            8   C2y C    10.2200  -22.0500
            9   C1x C     8.8900  -22.4700
            10  C2b C    11.4800  -26.3900
            11  C2b C    12.6700  -25.6900
            12  C1c C    13.8600  -26.3900
            13  C1c C    15.0500  -25.7600
            14  C1b C    16.2400  -26.3900
            15  C1a C    15.0500  -24.2900
            16  C3b C    17.4300  -25.7600
            17  C3b C    18.6900  -25.0600
            18  C1a C    19.8800  -24.3600
            19  O1a O    13.8600  -27.8600
            20  C2b C    10.6480  -20.7170
            21  C1b C     9.7055  -19.6775
            22  C1b C     8.3621  -19.9679
            23  C1b C     7.3986  -18.9047
            24  C6a C     6.0516  -19.1956
            25  O6a O     5.0897  -18.1338
            26  O6a O     5.6246  -20.5230
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     2   6 1 #Down
            7     4   7 1 #Down
            8     7   8 1
            9     8   9 1
            10    5   9 1 #Down
            11    3  10 1 #Up
            12   10  11 2
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 1
            17   14  16 1
            18   16  17 3
            19   17  18 1
            20   12  19 1 #Down
            21    8  20 2
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 2

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