KEGG   DRUG: D02724Help
Entry
D02724                      Drug                                   

Name
Bimatoprost (JAN/USAN/INN);
Lumigan (TN)
Product
  Generic
Formula
C25H37NO4
Exact mass
415.2723
Mol weight
415.5656
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Lowers intraocular pressure (IOP) in patients with open angle glaucoma or ocular hypertension [syntheic prostamide analog] [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Comment
a synthetic prostamide analogue
Target
prostaglandin F receptor agonist [HSA:5737] [KO:K04262]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
Prostaglandins
Antiglaucoma agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EE Prostaglandin analogues
     S01EE03 Bimatoprost
      D02724  Bimatoprost (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Prostaglandin and Prostamide Analogs
   Bimatoprost
    D02724  Bimatoprost (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D02724  Bimatoprost (JAN/USAN/INN)
 2  Agents affecting individual organs
  26  Epidermides
   267  Hair remedies
    2679  Others
     D02724  Bimatoprost (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    prostaglandin F receptor
     Bimatoprost
      D02724  Bimatoprost (JAN/USAN/INN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02724
BRITE hierarchy
Other DBs
CAS: 
155206-00-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        30
            1   C1y C    11.4800  -17.9900
            2   C1y C    11.4800  -16.5900
            3   C1y C    10.1485  -16.1574
            4   C1x C     9.3256  -17.2900
            5   C1y C    10.1485  -18.4226
            6   O1a O     9.7197  -14.8378
            7   O1a O     9.7197  -19.7422
            8   C1b C    12.6924  -15.8900
            9   C2b C    13.9049  -16.5900
            10  C2b C    12.6924  -18.6900
            11  C2b C    13.9049  -17.9900
            12  C1c C    15.1173  -18.6900
            13  C1b C    16.3297  -17.9900
            14  C1b C    17.5422  -18.6900
            15  C2b C    15.3049  -16.5900
            16  C1b C    16.5424  -15.8900
            17  C1b C    17.7549  -16.5900
            18  C1b C    18.9673  -15.8900
            19  C5a C    20.1797  -16.5900
            20  N1b N    21.3922  -15.8900
            21  C1b C    22.6046  -16.5900
            22  O1a O    15.1173  -20.0900
            23  C8y C    17.5422  -20.0900
            24  C8x C    16.3508  -20.7781
            25  C8x C    16.3510  -22.1781
            26  C8x C    17.5636  -22.8779
            27  C8x C    18.7550  -22.1898
            28  C8x C    18.7547  -20.7898
            29  O5a O    20.1797  -17.9899
            30  C1a C    23.8211  -15.8877
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     3   6 1 #Down
            7     5   7 1 #Down
            8     2   8 1 #Down
            9     8   9 1
            10    1  10 1 #Up
            11   10  11 2
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    9  15 2
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   12  22 1 #Down
            23   14  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   23  28 1
            30   19  29 2
            31   21  30 1

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