KEGG   DRUG: D02734Help
Entry
D02734                      Drug                                   

Name
Abacavir succinate (USAN)
Formula
C14H18N6O. C4H6O4
Exact mass
404.1808
Mol weight
404.4204
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral [DS:H00406]
Remark
ATC code: 
Drug group: 
Comment
Nucleoside reverse transcriptase inhibitor (NRTI)
Patients who carry the HLA-B*5701 allele are at high risk for experiencing a hypersensitivity reaction to Abacavir
Target
RNA-directed DNA polymerase inhibitor
Interaction
Genomic biomarker: HLA-B [HSA:3106]
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF06 Abacavir
      D02734  Abacavir succinate (USAN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Abacavir
    D02734  Abacavir succinate (USAN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agent
   Reverse transcriptase inhibitor (RTI)
    Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs)
     Abacavir
      D02734  Abacavir succinate (USAN)
BRITE hierarchy
Other DBs
CAS: 
168146-84-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        29
            1   C6a C    30.8546  -17.5451
            2   C1b C    32.0651  -16.8462
            3   C1b C    33.2755  -17.5451
            4   C6a C    34.4860  -16.8462
            5   O6a O    35.6965  -17.5451
            6   O6a O    30.8546  -18.9428
            7   O6a O    34.4860  -15.4485
            8   O6a O    29.8663  -16.5568
            9   C8y C    23.2400  -16.8700
            10  C8y C    23.2400  -18.3400
            11  C8y C    24.4300  -16.1700
            12  N5x N    22.0500  -16.3800
            13  N4y N    21.9800  -18.7600
            14  N5x N    24.4300  -19.1100
            15  N1b N    24.4300  -14.8400
            16  N5x N    25.6900  -16.9400
            17  C8x C    21.2100  -17.5000
            18  C1y C    20.8600  -19.6700
            19  C8y C    25.6900  -18.4100
            20  C1y C    25.6900  -14.1400
            21  C1x C    19.6700  -18.9000
            22  C2x C    20.4400  -21.0000
            23  N1a N    26.8800  -19.1800
            24  C1x C    27.0900  -14.2100
            25  C1x C    26.3900  -12.9500
            26  C1y C    18.6200  -19.6700
            27  C2x C    19.1100  -21.0000
            28  C1b C    17.2900  -19.3200
            29  O1a O    16.2400  -20.1600
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   6 2
            6     4   7 2
            7     1   8 1
            8     9  10 2
            9     9  11 1
            10    9  12 1
            11   10  13 1
            12   10  14 1
            13   11  15 1
            14   11  16 2
            15   12  17 2
            16   18  13 1 #Up
            17   14  19 2
            18   15  20 1
            19   18  21 1
            20   18  22 1
            21   19  23 1
            22   20  24 1
            23   20  25 1
            24   21  26 1
            25   22  27 2
            26   26  28 1 #Up
            27   28  29 1
            28   13  17 1
            29   16  19 1
            30   24  25 1
            31   26  27 1

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