KEGG   DRUG: Abacavir succinateHelp
Entry
D02734                      Drug                                   

Name
Abacavir succinate (USAN)
Formula
C14H18N6O. C4H6O4
Exact mass
404.1808
Mol weight
404.4204
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor
 DG01656  HIV reverse transcriptase inhibitor
Remark
ATC code: 
Chemical group: 
Activity
Antiviral, Reverse transcriptase inhibitor
Comment
Nucleoside reverse transcriptase inhibitor (NRTI)
Patients who carry the HLA-B*5701 allele are at high risk for experiencing a hypersensitivity reaction to Abacavir
Target
RNA-directed DNA polymerase
Interaction
Genomic biomarker: HLA-B [HSA:3106]
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF06 Abacavir
      D02734  Abacavir succinate (USAN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Abacavir
    D02734  Abacavir succinate (USAN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Reverse transcriptase inhibitor (RTI)
    Nucleoside and nucleotide reverse transcriptase inhibitor (NRTIs)
     Abacavir
      D02734  Abacavir succinate (USAN)
BRITE hierarchy
Other DBs
CAS: 
168146-84-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        29
            1   C6a C    30.8546  -17.5451
            2   C1b C    32.0651  -16.8462
            3   C1b C    33.2755  -17.5451
            4   C6a C    34.4860  -16.8462
            5   O6a O    35.6965  -17.5451
            6   O6a O    30.8546  -18.9428
            7   O6a O    34.4860  -15.4485
            8   O6a O    29.8663  -16.5568
            9   C8y C    23.2400  -16.8700
            10  C8y C    23.2400  -18.3400
            11  C8y C    24.4300  -16.1700
            12  N5x N    22.0500  -16.3800
            13  N4y N    21.9800  -18.7600
            14  N5x N    24.4300  -19.1100
            15  N1b N    24.4300  -14.8400
            16  N5x N    25.6900  -16.9400
            17  C8x C    21.2100  -17.5000
            18  C1y C    20.8600  -19.6700
            19  C8y C    25.6900  -18.4100
            20  C1y C    25.6900  -14.1400
            21  C1x C    19.6700  -18.9000
            22  C2x C    20.4400  -21.0000
            23  N1a N    26.8800  -19.1800
            24  C1x C    27.0900  -14.2100
            25  C1x C    26.3900  -12.9500
            26  C1y C    18.6200  -19.6700
            27  C2x C    19.1100  -21.0000
            28  C1b C    17.2900  -19.3200
            29  O1a O    16.2400  -20.1600
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   6 2
            6     4   7 2
            7     1   8 1
            8     9  10 2
            9     9  11 1
            10    9  12 1
            11   10  13 1
            12   10  14 1
            13   11  15 1
            14   11  16 2
            15   12  17 2
            16   18  13 1 #Up
            17   14  19 2
            18   15  20 1
            19   18  21 1
            20   18  22 1
            21   19  23 1
            22   20  24 1
            23   20  25 1
            24   21  26 1
            25   22  27 2
            26   26  28 1 #Up
            27   28  29 1
            28   13  17 1
            29   16  19 1
            30   24  25 1
            31   26  27 1

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