KEGG   DRUG: D02745Help
Entry
D02745                      Drug                                   

Name
Interferon alfa-2b (genetical recombination) (JAN);
Interferon alfa-2b (USAN);
Intron A (TN)
Product
Formula
C860H1353N229O255S9
Exact mass
19256.7431
Mol weight
19268.9111
Sequence
CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI
QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR
KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
  Type
Peptide
Activity
Antineoplastic;
Biological response modifier
[DS:H00004 H00021 H00034 H00038 H00045]
Remark
Therapeutic category: 
ATC code: 
Target
interferon receptor 1 agonist [HSA:3454] [KO:K05130];
interferon receptor 2 agonist [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity  
 
Interaction
Drug interaction
Structure map
Antiviral agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D02745  Interferon alfa-2b (genetical recombination) (JAN); Interferon alfa-2b (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB05 Interferon alfa-2b
      D02745  Interferon alfa-2b (genetical recombination) (JAN); Interferon alfa-2b (USAN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Interferon Alfa-2b, Recombinant
    D02745  Interferon alfa-2b (genetical recombination) (JAN); Interferon alfa-2b (USAN)
  Anti-hepatitis C (HCV) Agents
   Interferon Alfa-2b, Recombinant
    D02745  Interferon alfa-2b (genetical recombination) (JAN); Interferon alfa-2b (USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class II cytokine receptors (interferon/IL-10 family receptors)
   interferon receptor 1 [HSA:3454] [KO:K05130]
    Interferon alfa-2b [ATC:L03AB05]
     D02745  Interferon alfa-2b (genetical recombination) (JAN); Interferon alfa-2b (USAN)
   interferon receptor 2 [HSA:3455] [KO:K05131]
    Interferon alfa-2b [ATC:L03AB05]
     D02745  Interferon alfa-2b (genetical recombination) (JAN); Interferon alfa-2b (USAN)
Antineoplastics [BR:br08308]
 Biologic response modifiers
  Interferones
   Interferon alfa-2b [ATC:L03AB05]
    D02745  Interferon alfa-2b (genetical recombination) (JAN); Interferon alfa-2b (USAN)
BRITE hierarchy
Other DBs
CAS: 
99210-65-8
PubChem: 
DrugBank: 

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