KEGG   DRUG: D02747Help
Entry
D02747                      Drug                                   

Name
Peginterferon alfa-2a (genetical recombination) (JAN);
Peginterferon alfa-2a (USAN/INN);
Pegasys (TN)
Product
Formula
C10H17N2O5R(C2H4O)n(C2H4O)n
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
CDLPQTHSLG SRRTLMLLAQ MRKISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI
QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR
KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
(Disulfide bridge:1-98; 29-138, Pegylation site: 31; 121; 131; 134)
  Type
Peptide
Activity
Treatment of hepatitis C
Remark
Therapeutic category: 
ATC code: 
Comment
R: Interferon alfa-2a [DR:D00745]
Target
interferon receptor 1 agonist [HSA:3454] [KO:K05130];
interferon receptor 2 agonist [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity  
 
Interaction
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB11 Peginterferon alfa-2a
      D02747  Peginterferon alfa-2a (genetical recombination) (JAN); Peginterferon alfa-2a (USAN/INN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Peginterferon Alfa-2a
    D02747  Peginterferon alfa-2a (genetical recombination) (JAN); Peginterferon alfa-2a (USAN/INN)
  Anti-hepatitis C (HCV) Agents
   Peginterferon Alfa-2a
    D02747  Peginterferon alfa-2a (genetical recombination) (JAN); Peginterferon alfa-2a (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D02747  Peginterferon alfa-2a (genetical recombination) (JAN); Peginterferon alfa-2a (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class II cytokine receptors (interferon/IL-10 family receptors)
   interferon receptor 1
    Peginterferon alfa-2a
     D02747  Peginterferon alfa-2a (genetical recombination) (JAN); Peginterferon alfa-2a (USAN/INN)
   interferon receptor 2
    Peginterferon alfa-2a
     D02747  Peginterferon alfa-2a (genetical recombination) (JAN); Peginterferon alfa-2a (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
198153-51-4
PubChem: 
DrugBank: 
KCF data Show

ATOM        24
            1   O2a O    20.5100  -27.6500
            2   C1b C    21.7224  -28.3500
            3   C1b C    22.9349  -27.6500
            4   O7a O    24.1473  -28.3500
            5   C7a C    25.3597  -27.6500
            6   N1b N    26.5722  -28.3500
            7   C1c C    27.7846  -27.6500
            8   C5a C    28.9970  -28.3500
            9   R   R    30.2095  -27.6500
            10  O5a O    28.9970  -29.7499
            11  C1b C    27.7846  -26.2500
            12  O6a O    25.3597  -26.2501
            13  C1b C    26.5762  -25.5523
            14  C1b C    26.5762  -24.1523
            15  C1b C    25.3807  -23.4620
            16  N1b N    24.1954  -24.1463
            17  C7a C    23.0031  -23.4577
            18  O7a O    21.8142  -24.1441
            19  C1b C    20.6238  -23.4566
            20  C1b C    19.4339  -24.1436
            21  O6a O    23.0031  -22.0503
            22  O2a O    18.2439  -23.4563
            23  C1a C    19.2976  -28.3500
            24  C1a C    17.0537  -24.1433
BOND        23
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     8  10 2
            10    7  11 1 #Up
            11    5  12 2
            12   11  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   17  21 2
            21   20  22 1
            22    1  23 1
            23   22  24 1
BRACKET     1    17.9200  -25.1300   17.9200  -23.0300
            1    20.7900  -23.0300   20.7900  -25.1300
            1  n
 ORIGINAL  1   19  20  22
 REPEAT    1
            2    20.1600  -29.3300   20.1600  -27.2300
            2    23.1000  -27.2300   23.1000  -29.3300
            2  n
 ORIGINAL  2    1   2   3
 REPEAT    2

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