KEGG   DRUG: Acamprosate calciumHelp
Entry
D02780                      Drug                                   

Name
Acamprosate calcium (JAN/USAN);
Campral (TN);
Regtect (TN)
Product
  Generic
Formula
(C5H10NO4S)2. Ca
Exact mass
400.0287
Mol weight
400.4824
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
Other
 DG01718  Drugs for addictive disorder
  DG01716  Drugs for alcohol dependence
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
NMDA receptor antagonist
  Disease
Alcohol dependence [DS:H01611]
Comment
Treatment of alcohol dependency
Target
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Alcoholism
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BB Drugs used in alcohol dependence
     N07BB03 Acamprosate
      D02780  Acamprosate calcium (JAN/USAN)
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Alcohol Deterrents/Anti-craving
   Acamprosate
    D02780  Acamprosate calcium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02780  Acamprosate calcium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Acamprosate
      D02780  Acamprosate calcium (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02780
BRITE hierarchy
Other DBs
CAS: 
77337-73-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C1a C    21.6233  -20.9826
            2   C5a C    22.8217  -21.6744
            3   N1b N    24.0200  -20.9826
            4   C1b C    25.2183  -21.6744
            5   C1b C    26.4166  -20.9826
            6   C1b C    27.6150  -21.6744
            7   S4a S    28.8134  -20.9826
            8   O5a O    22.8217  -23.0582
            9   O1d O    30.0258  -21.6827 #-
            10  O1d O    30.0258  -20.2826
            11  O1d O    27.6009  -20.2826
            12  Z   Ca   34.4228  -22.0203 #2+
            13  C1a C    21.6233  -20.9826
            14  C5a C    22.8217  -21.6744
            15  N1b N    24.0200  -20.9826
            16  C1b C    25.2183  -21.6744
            17  C1b C    26.4166  -20.9826
            18  C1b C    27.6150  -21.6744
            19  S4a S    28.8134  -20.9826
            20  O1d O    30.0258  -21.6827 #-
            21  O1d O    30.0258  -20.2826
            22  O1d O    27.6009  -20.2826
            23  O5a O    22.8217  -23.0582
BOND        20
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     2   8 2
            8     7   9 1
            9     7  10 2
            10    7  11 2
            11   13  14 1
            12   14  15 1
            13   15  16 1
            14   16  17 1
            15   17  18 1
            16   18  19 1
            17   14  23 2
            18   19  20 1
            19   19  21 2
            20   19  22 2
BRACKET     1    19.7400  -24.0100   19.7400  -18.6200
            1    31.0800  -18.6200   31.0800  -24.0100
            1  2
 ORIGINAL  1    1   2   3   4   5   6   7   9  10  11   8
 REPEAT    1   13  14  15  16  17  18  19  20  21  22  23

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