| Entry |
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| Name |
Fosamprenavir calcium hydrate (JAN);
Lexiva (TN)
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| Formula |
C25H34N3O9PS. Ca. xH2O
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| Structure |
     |
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| Activity |
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| Remark |
Therapeutic category: ATC code: |
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| Target |
HIV protease inhibitor [CPD: C19849] |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565], CYP1A2 [HSA: 1544], CYP2C9 [HSA: 1559]
|
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| Interaction |
CYP inhibition: CYP3A inhibitor [KO: K07424]
 |
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| Structure map |
| Anti-HIV agents | | HIV protease inhibitors |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D02867 Fosamprenavir calcium hydrate (JAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE07 Fosamprenavir
D02867 Fosamprenavir calcium hydrate (JAN)
USP drug classification [BR:br08302]
Antivirals
Anti-HIV Agents, Protease Inhibitors
Fosamprenavir
D02867 Fosamprenavir calcium hydrate (JAN)
Antiinfectives [BR:br08307]
Antivirals
Anti-HIV agent
Protease inhibitor (PIs)
Nonpeptidic
Fosamprenavir [ATC:J05AE07]
D02867 Fosamprenavir calcium hydrate (JAN)
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| Other DBs |
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| KCF data |
ATOM 41
1 O0 O 44.4877 -16.3271
2 N1c N 32.7600 -13.9300
3 C1b C 33.9500 -13.2300
4 S4a S 31.2900 -13.2300
5 C1c C 35.1400 -13.9300
6 C8y C 29.8200 -13.9300
7 C1c C 36.3300 -13.2300
8 C1b C 36.3300 -11.8300
9 N1b N 37.4500 -13.9300
10 C8y C 35.1400 -11.2000
11 C7a C 38.6400 -13.2300
12 C8x C 33.9500 -11.8300
13 C8x C 35.1400 -9.8000
14 O7a O 39.8300 -13.9300
15 O6a O 38.6400 -11.8300
16 C8x C 32.7600 -11.2000
17 C8x C 33.9500 -9.1000
18 C1y C 41.0200 -13.3000
19 C8x C 32.7600 -9.8000
20 C8x C 29.8200 -15.2600
21 C8x C 28.7000 -15.9600
22 C8y C 27.5100 -15.2600
23 C8x C 27.5100 -13.9300
24 C8x C 28.7000 -13.2300
25 N1a N 26.3200 -16.0300
26 C1b C 32.7600 -15.8900
27 O2b O 35.0700 -15.9600
28 P1b P 36.3300 -16.6600
29 O1c O 37.3800 -17.2900 #-
30 O3c O 32.2000 -12.2500
31 O3c O 30.3100 -12.2500
32 O1c O 35.6300 -17.8500 #-
33 O1c O 36.9600 -15.5400
34 C1c C 31.6400 -16.5200
35 C1a C 31.6400 -17.9200
36 C1a C 30.4500 -15.8900
37 C1x C 41.0200 -11.9000
38 C1x C 42.2800 -13.7200
39 C1x C 43.1200 -12.6000
40 O2x O 42.2800 -11.5500
41 Z Ca 39.2700 -17.3600 #2+
BOND 41
1 2 3 1
2 2 4 1
3 3 5 1
4 4 6 1
5 5 7 1
6 7 8 1 #Down
7 7 9 1
8 8 10 1
9 9 11 1
10 10 12 2
11 10 13 1
12 11 14 1
13 11 15 2
14 12 16 1
15 13 17 2
16 18 14 1 #Down
17 16 19 2
18 17 19 1
19 6 20 2
20 20 21 1
21 21 22 2
22 22 23 1
23 23 24 2
24 6 24 1
25 22 25 1
26 2 26 1
27 5 27 1 #Down
28 27 28 1
29 28 29 1
30 4 30 2
31 4 31 2
32 28 32 1
33 28 33 2
34 26 34 1
35 34 35 1
36 34 36 1
37 18 37 1
38 18 38 1
39 38 39 1
40 39 40 1
41 37 40 1
BRACKET 1 42.3500 -17.2900 42.3500 -15.2600
1 45.2900 -15.2600 45.2900 -17.2900
1 x
ORIGINAL 1 1
REPEAT 1
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