KEGG   DRUG: D02867Help
Entry
D02867                      Drug                                   

Name
Fosamprenavir calcium hydrate (JAN);
Lexiva (TN)
Formula
C25H34N3O9PS. Ca. xH2O
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral [DS:H00406]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
prodrug, active substance: Amprenavir [DR:D00894]
Target
HIV protease inhibitor [CPD:C19849]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565], CYP1A2 [HSA:1544], CYP2C9 [HSA:1559]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Anti-HIV agents
HIV protease inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AE Protease inhibitors
     J05AE07 Fosamprenavir
      D02867  Fosamprenavir calcium hydrate (JAN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Protease Inhibitors
   Fosamprenavir
    D02867  Fosamprenavir calcium hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D02867  Fosamprenavir calcium hydrate (JAN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Protease inhibitor (PIs)
    Nonpeptidic
     Fosamprenavir
      D02867  Fosamprenavir calcium hydrate (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Fosamprenavir
    D02867  Fosamprenavir calcium hydrate (JAN)
  CYP2C9
   Fosamprenavir
    D02867  Fosamprenavir calcium hydrate (JAN)
  CYP2D6
   Fosamprenavir
    D02867  Fosamprenavir calcium hydrate (JAN)
  CYP3A4
   Fosamprenavir
    D02867  Fosamprenavir calcium hydrate (JAN)
 Inhbitors
  CYP3A
   Fosamprenavir
    D02867  Fosamprenavir calcium hydrate (JAN)
BRITE hierarchy
Other DBs
PubChem: 
LigandBox: 
KCF data Show

ATOM        41
            1   O0  O    23.4177  -18.9171
            2   Z   Ca    7.9800  -25.9700 #2+
            3   N1c N    16.1000  -22.0500
            4   C1b C    14.9800  -21.3500
            5   S4a S    17.6400  -21.3500
            6   C1c C    13.7900  -22.0500
            7   C8y C    19.0400  -22.0500
            8   C1c C    12.6000  -21.3500
            9   N1b N    11.4800  -22.0500
            10  C7a C    10.2900  -21.3500
            11  O7a O     9.1000  -22.0500
            12  O6a O    10.2900  -20.0200
            13  C1y C     7.9100  -21.4200
            14  C8x C    19.0400  -23.4500
            15  C8x C    20.2300  -24.0800
            16  C8y C    21.3500  -23.4500
            17  C8x C    21.3500  -22.0500
            18  C8x C    20.2300  -21.3500
            19  N1a N    22.6100  -24.1500
            20  O2b O    13.7900  -24.0800
            21  P1b P    12.6000  -24.8500
            22  O1c O    11.0600  -25.6200 #-
            23  O3c O    16.6600  -20.4400
            24  O3c O    18.5500  -20.4400
            25  O1c O    13.3000  -26.0400 #-
            26  O1c O    11.9000  -23.6600
            27  C1x C     7.9100  -20.0900
            28  C1x C     6.6500  -21.8400
            29  C1x C     5.8100  -20.7900
            30  O2x O     6.6500  -19.6700
            31  C1b C    16.1000  -23.4500
            32  C1c C    17.2900  -24.2200
            33  C1a C    18.5500  -23.5200
            34  C1a C    17.2900  -25.5500
            35  C1b C    12.6000  -19.9500
            36  C8y C    13.7900  -19.2500
            37  C8x C    15.0500  -19.9500
            38  C8x C    16.2400  -19.1800
            39  C8x C    16.2400  -17.7800
            40  C8x C    14.9800  -17.0800
            41  C8x C    13.7900  -17.8500
BOND        41
            1     3   4 1
            2     3   5 1
            3     4   6 1
            4     5   7 1
            5     6   8 1
            6     8   9 1
            7     9  10 1
            8    10  11 1
            9    10  12 2
            10   13  11 1 #Up
            11    7  14 2
            12   14  15 1
            13   15  16 2
            14   16  17 1
            15   17  18 2
            16    7  18 1
            17   16  19 1
            18    6  20 1 #Up
            19   20  21 1
            20   21  22 1
            21    5  23 2
            22    5  24 2
            23   21  25 1
            24   21  26 2
            25   13  27 1
            26   13  28 1
            27   28  29 1
            28   29  30 1
            29   27  30 1
            30    3  31 1
            31   31  32 1
            32   32  33 1
            33   32  34 1
            34    8  35 1 #Up
            35   35  36 1
            36   36  37 2
            37   37  38 1
            38   38  39 2
            39   39  40 1
            40   40  41 2
            41   36  41 1
BRACKET     1    21.2800  -19.8800   21.2800  -17.7800
            1    24.2200  -17.7800   24.2200  -19.8800
            1  x
 ORIGINAL  1    1
 REPEAT    1

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