KEGG   DRUG: D02876Help
Entry
D02876                      Drug                                   

Name
Alvameline maleate (USAN)
Formula
C9H15N5. C4H4O4
Exact mass
309.1437
Mol weight
309.3211
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
A partial M1 agonist and M2/M3 antagonist
Target
muscarinic cholinergic receptor M1 agonist [HSA:1128] [KO:K04129];
muscarinic cholinergic receptor M2/M3 antagonist [HSA:1129 1131] [KO:K04130 K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion  
 
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M1
     Alvameline
      D02876  Alvameline maleate (USAN)
    muscarinic cholinergic receptor M2
     Alvameline
      D02876  Alvameline maleate (USAN)
    muscarinic cholinergic receptor M3
     Alvameline
      D02876  Alvameline maleate (USAN)
BRITE hierarchy
Other DBs
CAS: 
219581-36-9
PubChem: 
LigandBox: 
KCF data Show

ATOM        22
            1   C2b C    25.2513  -16.9630
            2   C2b C    23.5507  -16.9630
            3   C6a C    25.8891  -18.1677
            4   C6a C    22.9129  -18.1677
            5   O6a O    25.2513  -19.3015
            6   O6a O    27.2355  -18.1677
            7   O6a O    21.4957  -18.1677
            8   O6a O    23.5507  -19.3015
            9   N1y N    10.1500  -17.6400
            10  C1x C    10.1500  -19.0400
            11  C1x C    11.3400  -19.7400
            12  C2x C    12.6000  -19.0400
            13  C2y C    12.6000  -17.6400
            14  C1x C    11.3400  -16.9400
            15  C1a C     8.9600  -16.9400
            16  C8y C    13.7900  -16.9400
            17  N5x N    14.9100  -17.7800
            18  N4y N    16.0300  -16.9400
            19  N5x N    15.6100  -15.6100
            20  N5x N    14.2100  -15.6100
            21  C1b C    17.2200  -17.6400
            22  C1a C    18.4100  -16.9400
BOND        22
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 1
            9    10  11 1
            10   11  12 1
            11   12  13 2
            12   13  14 1
            13    9  14 1
            14    9  15 1
            15   13  16 1
            16   16  17 2
            17   17  18 1
            18   18  19 1
            19   19  20 2
            20   16  20 1
            21   18  21 1
            22   21  22 1

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